Detail Information

Basic Information:


  VIRBase ID:  

HHID00057415

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-339-5p:           CCR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-339-5p CCR7
miRBase
Accession/Entrez ID		 MIMAT0000764 1236
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BLR2//CC-CKR-7//CCR-7//CD197//CDw197//CMKBR7//EBI1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-339-5p
rs1193791493 chr7:1022993    G/A
rs1195161234 chr7:1023001    G/A
rs1389808688 chr7:1022998    C/A
rs1392685246 chr7:1023002    G/C
rs145196722 chr7:1022990    C/T
rs376453121 chr7:1023004    G/A
rs751903838 chr7:1022992    T/G
rs757540161 chr7:1022995    G/A
rs757540161 chr7:1022995    G/T
rs764617675 chr7:1022991    G/A
rs764617675 chr7:1022991    G/T
rs781650480 chr7:1022999    C/G
rs1171417851 chr7:1023011    G/A
rs1231148073 chr7:1023007    C/G
rs1231148073 chr7:1023007    C/T
rs749380470 chr7:1023010    G/A
rs756414544 chr7:1023005    G/A
rs756414544 chr7:1023005    G/T
rs780223286 chr7:1023009    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCR7
chr17:38713987(-) A-I      intronic
chr17:38713981(-) A-I      intronic
chr17:38713982(-) A-I      intronic
chr17:38714005(-) A-I      intronic
chr17:38713986(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCR7
chr17:38710149-38710150(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710156-38710157(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710237-38710238(-) m6A 3'UTR       27371828
chr17:38710482-38710483(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710495-38710496(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710510-38710511(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710537-38710538(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710555-38710556(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710574-38710575(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710590-38710591(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710604-38710605(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710623-38710624(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710706-38710707(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710727-38710728(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710734-38710735(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710755-38710756(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710772-38710773(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710796-38710797(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710913-38710914(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710966-38710967(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710975-38710976(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38711016-38711017(-) m6A CDS       24981863//28052920//27371828
chr17:38711102-38711103(-) m6A CDS       27371828
chr17:38711819-38711820(-) m6A CDS       28052920//26404942
chr17:38711859-38711860(-) m6A CDS       28052920//26404942
chr17:38711966-38711967(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712011-38712012(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712026-38712027(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38715189-38715190(-) m6A 5'UTR//CDS//intron       28052920//27371828
chr17:38716998-38716999(-) m6A 5'UTR//intron       27371828
chr17:38717003-38717004(-) m6A 5'UTR//intron       27371828
chr17:38717013-38717014(-) m6A 5'UTR//intron       27371828
chr17:38717070-38717071(-) m6A 5'UTR//intron       -
chr17:38717106-38717107(-) m6A 5'UTR//intron       -
chr17:38717189-38717190(-) m6A 5'UTR//intron       -
chr17:38717195-38717196(-) m6A 5'UTR//intron       -
chr17:38717227-38717228(-) m6A 5'UTR//intron       -
chr17:38721656-38721657(-) m6A 5'UTR//CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-339-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Plasma     23663360
Exosome Blood|Kidney tissue|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
CCR7
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-339-5p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
Midostaurin 9829523 Drug resistant
8-Aminoadenosine 96851 Drug resistant
Gardenin B 96539 Drug sensitive
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Vancide 26 79411 Drug sensitive
1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive
Azure B 68275 Drug sensitive
Sulbentine 67686 Drug sensitive
2-Debenzoyl-2-(3',5'-difluorobenzoyl)-A-nortaxol 6712230 Drug sensitive
Baccharinoid B4 6711263 Drug sensitive
Neocuproine 65237 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Pharmakon1600-01503602 60148415 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Aspiculamycin hcl 54600418 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Hemiasterlin 5352092 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Vorinostat 5311 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propyl dinonanoate 406480 Drug sensitive
Aminopyrimidine-CH3 406278 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
5'-Formyl-2,5-bis(2'-selenyl)-N-methylpyrrol 394652 Drug sensitive
Sjg-136 393111 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
ARQ monoacetate 385441 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug sensitive
Predorine 333830 Drug sensitive
Rocaglamide 331783 Drug sensitive
Rustaiyan A 324967 Drug sensitive
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
Bromocriptine 31101 Drug sensitive
Salinomycin 3085092 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
Antineoplastic-92915 261051 Drug sensitive
Hydrazine sulfate 24842 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Drostanolone propionate 224004 Drug sensitive
4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid 219564 Drug sensitive
Actinomycin VII 20055431 Drug sensitive
Sudan II 18386 Drug sensitive
Erlotinib 176870 Drug resistant
Antineoplastic-633273 15954131 Drug sensitive
Arsenic trioxide 14888 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
Acid Alizarine Red B 135565636 Drug sensitive
Emofolin sodium 135475347 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Astraphloxin 12299852 Drug sensitive
Melampodinin 11953936 Drug sensitive
2,2'-Bioxirane 11254 Drug sensitive
Gentian violet 11057 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Perillyl alcohol 10819 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
Chimaphilin 101211 Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
(Z)-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)-5-methoxyindolin-2-one - Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci) - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
salicylaldehyde, 5-bromo- (8ci) - Drug sensitive
(-)-dactylolide - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
antineoplastic-d665837 - Drug sensitive
aromoline - Drug sensitive
arylmethylene-f - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
from cephalodiscus gilchristi - Drug sensitive
his 47-methyl ct - Drug sensitive
isatin dr - Drug sensitive
leucinostatine d - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
pyrazoline derivative - Drug sensitive
Uniroyal Compound-38 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-339-5p
Hyaluronidase 91820602 Drug interaction    RC00004468
Oxaliplatine 6857599 Drug interaction    RC00004467
Gemcitabine 60750 Drug interaction    RC00004461
Eloxatine 5310940 Drug interaction    RC00004466
4-Hydroxynonenal 5283344 Drug interaction    RC00004465
Cholecalciferol 5280795 Drug interaction    RC00004464
5-Fluorouracil 3385 Drug interaction    RC00004459
Doxorubicin 31703 Drug interaction    RC00004460
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004458
Tamoxifen 2733526 Drug interaction    RC00004463
Verapamil 2520 Drug interaction    RC00004457
Docetaxel 148124 Drug interaction    RC00004462
Leucovorin 135403648 Drug interaction    RC00004469
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-339-5p
Cisplatin 5702198       25356050
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-339-5p
Interactor2: CCR7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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