Basic Information:

  VIRBase ID:  

HHID00057404

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-338-3p:  MIMAT0000763          BAG4:  NM_001204878     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-338-3p	BAG4
miRBase Accession/Entrez ID	MIMAT0000763	9530
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAG-4//SODD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-338-3p	rs1489376916 chr17:81125899    T/A rs931624243 chr17:81125895    T/C rs1210197719 chr17:81125902    T/C rs1251048260 chr17:81125907    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BAG4	chr8:38048553(+) A-I      intronic chr8:38047485(+) A-I      intronic chr8:38047461(+) A-I      intronic chr8:38046546(+) A-I      intronic chr8:38043324(+) A-I      intronic chr8:38042487(+) A-I      intronic chr8:38042454(+) A-I      intronic chr8:38042453(+) A-I      intronic chr8:38042451(+) A-I      intronic chr8:38042442(+) A-I      intronic chr8:38040845(+) A-I      intronic chr8:38039210(+) A-I      intronic chr8:38039108(+) A-I      intronic chr8:38037996(+) A-I      intronic chr8:38037865(+) A-I      intronic chr8:38037855(+) A-I      intronic chr8:38037786(+) A-I      intronic chr8:38037164(+) A-I      intronic chr8:38037163(+) A-I      intronic chr8:38037902(+) A-I      intronic chr8:38036752(+) A-I      intronic chr8:38035830(+) A-I      intronic chr8:38051229(+) A-I      intronic chr8:38063825(+) A-I      intronic chr8:38063586(+) A-I      intronic chr8:38062815(+) A-I      intronic chr8:38062788(+) A-I      intronic chr8:38062642(+) A-I      intronic chr8:38061237(+) A-I      intronic chr8:38060977(+) A-I      intronic chr8:38060196(+) A-I      intronic chr8:38057617(+) A-I      intronic chr8:38056156(+) A-I      intronic chr8:38056146(+) A-I      intronic chr8:38056136(+) A-I      intronic chr8:38055782(+) A-I      intronic chr8:38055771(+) A-I      intronic chr8:38055347(+) A-I      intronic chr8:38055330(+) A-I      intronic chr8:38055318(+) A-I      intronic chr8:38055249(+) A-I      intronic chr8:38054582(+) A-I      intronic chr8:38054474(+) A-I      intronic chr8:38054433(+) A-I      intronic chr8:38054430(+) A-I      intronic chr8:38054419(+) A-I      intronic chr8:38054370(+) A-I      intronic chr8:38054361(+) A-I      intronic chr8:38052773(+) A-I      intronic chr8:38051993(+) A-I      intronic chr8:38051517(+) A-I      intronic chr8:38051516(+) A-I      intronic chr8:38051225(+) A-I      intronic chr8:38051145(+) A-I      intronic chr8:38049021(+) A-I      intronic chr8:38049013(+) A-I      intronic chr8:38069772(+) A-I      3'UTR chr8:38069773(+) A-I      3'UTR chr8:38069806(+) A-I      3'UTR chr8:38069775(+) A-I      3'UTR chr8:38050900(+) A-I      intronic chr8:38039273(+) A-I      intronic chr8:38049039(+) A-I      intronic chr8:38061939(+) A-I      intronic chr8:38062666(+) A-I      intronic chr8:38038539(+) A-I      intronic chr8:38038853(+) A-I      intronic chr8:38037239(+) A-I      intronic chr8:38055357(+) A-I      intronic chr8:38050843(+) A-I      intronic chr8:38037920(+) A-I      intronic chr8:38043272(+) A-I      intronic chr8:38036842(+) A-I      intronic chr8:38051357(+) A-I      intronic chr8:38052919(+) A-I      intronic chr8:38046554(+) A-I      intronic chr8:38064867(+) A-I      intronic chr8:38052940(+) A-I      intronic chr8:38049022(+) A-I      intronic chr8:38039400(+) A-I      intronic chr8:38037894(+) A-I      intronic chr8:38051213(+) A-I      intronic chr8:38061238(+) A-I      intronic chr8:38054534(+) A-I      intronic chr8:38054475(+) A-I      intronic chr8:38060328(+) A-I      intronic chr8:38056188(+) A-I      intronic chr8:38046429(+) A-I      intronic chr8:38049091(+) A-I      intronic chr8:38059068(+) A-I      intronic chr8:38052877(+) A-I      intronic chr8:38060036(+) A-I      intronic chr8:38058910(+) A-I      intronic chr8:38043127(+) A-I      intronic chr8:38052834(+) A-I      intronic chr8:38038869(+) A-I      intronic chr8:38051184(+) A-I      intronic chr8:38057655(+) A-I      intronic chr8:38045277(+) A-I      intronic chr8:38049095(+) A-I      intronic chr8:38037947(+) A-I      intronic chr8:38036855(+) A-I      intronic chr8:38052882(+) A-I      intronic chr8:38048089(+) A-I      intronic chr8:38052035(+) A-I      intronic chr8:38061965(+) A-I      intronic chr8:38046653(+) A-I      intronic chr8:38047510(+) A-I      intronic chr8:38051107(+) A-I      intronic chr8:38050026(+) A-I      intronic chr8:38037881(+) A-I      intronic chr8:38037898(+) A-I      intronic chr8:38042486(+) A-I      intronic chr8:38039302(+) A-I      intronic chr8:38039350(+) A-I      intronic chr8:38043182(+) A-I      intronic chr8:38054050(+) A-I      intronic chr8:38061232(+) A-I      intronic chr8:38036858(+) A-I      intronic chr8:38041999(+) A-I      intronic chr8:38060043(+) A-I      intronic chr8:38038666(+) A-I      intronic chr8:38046576(+) A-I      intronic chr8:38046405(+) A-I      intronic chr8:38064654(+) A-I      intronic chr8:38061273(+) A-I      intronic chr8:38037950(+) A-I      intronic chr8:38046308(+) A-I      intronic chr8:38046575(+) A-I      intronic chr8:38050826(+) A-I      intronic chr8:38052861(+) A-I      intronic chr8:38035806(+) A-I      intronic chr8:38049101(+) A-I      intronic chr8:38036778(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BAG4	chr8:38035796(+) T-C intron -    22484847 chr8:38035806(+) A-G intron -    22484847 chr8:38036742(+) A-G intron -    22484847 chr8:38036747(+) A-G intron -    22484847 chr8:38038539(+) A-G intron -    22484847 chr8:38038666(+) A-G intron -    22484847 chr8:38043272(+) A-G intron -    22484847 chr8:38046405(+) A-G intron -    22484847 chr8:38046429(+) A-G intron -    22484847 chr8:38046575(+) A-G intron -    22484847 chr8:38046576(+) A-G intron -    22484847 chr8:38047510(+) A-G intron -    22484847 chr8:38050892(+) A-G intron -    22484847 chr8:38050900(+) A-G intron -    22484847 chr8:38052035(+) A-G intron -    22484847 chr8:38052919(+) A-G intron -    22484847 chr8:38054475(+) A-G intron -    22484847 chr8:38055357(+) A-G intron -    22484847 chr8:38055781(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BAG4	chr8:38034117-38034118(+) m6A 5'UTR//intron       24981863 chr8:38034163-38034164(+) m6A 5'UTR//intron       24981863 chr8:38034197-38034198(+) m6A 5'UTR//intron       24981863 chr8:38066792-38066793(+) m6A CDS//intron       24284625//24981863//22608085 chr8:38066832-38066833(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr8:38066880-38066881(+) m6A 3'UTR//intron       24284625//22608085 chr8:38067565-38067566(+) m6A CDS       24284625//24981863//22608085 chr8:38067612-38067613(+) m6A CDS       24284625//24981863//22608085 chr8:38067619-38067620(+) m6A CDS       24284625//24981863//22608085 chr8:38067818-38067819(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr8:38067849-38067850(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067893-38067894(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067902-38067903(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067918-38067919(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067931-38067932(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068022-38068023(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068057-38068058(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068150-38068151(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr8:38068223-38068224(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr8:38068252-38068253(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068311-38068312(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068340-38068341(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068354-38068355(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068371-38068372(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068394-38068395(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068470-38068471(+) m6A 3'UTR       24981863//22608085 chr8:38068486-38068487(+) m6A 3'UTR       24981863//22608085 chr8:38068586-38068587(+) m6A 3'UTR       27773535 chr8:38070589-38070590(+) m6A 3'UTR       27773535 chr8:38070623-38070624(+) m6A 3'UTR       27773535 chr8:38070692-38070693(+) m6A 3'UTR       24981863//27773535 chr8:38070728-38070729(+) m6A 3'UTR       24981863//27773535 chr8:38070813-38070814(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-338-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome B cell line (Raji)|Primary dendritic cells     21505438 Exosome Brain tissue     23382797 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	BAG4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-338-3p	Verrucarin A 6326658 Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-338-3p	10-Hydroxycamptothecin 97226 Drug interaction    RC00004452 Gemcitabine 60750 Drug interaction    RC00004451 Eloxatine 5310940 Drug interaction    RC00004456 Cholecalciferol 5280795 Drug interaction    RC00004455 Oxidopamine 4624 Drug interaction    RC00004448 Norepinephrine 439260 Drug interaction    RC00004454 Paclitaxel 36314 Drug interaction    RC00004450 5-Fluorouracil 3385 Drug interaction    RC00004447 Doxorubicin 31703 Drug interaction    RC00004449 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004446 Sorafenib 216239 Drug interaction    RC00004453

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-338-3p	5-Fluorouracil 3385       28928082 Sorafenib 216239       25531114 Docetaxel 148124       31063487 CID 14440697 14440697       21293479

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-338-3p
Interactor2: BAG4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.