Detail Information

Basic Information:


  VIRBase ID:  

HHID00057306

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-148b-3p:           PEA15:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-148b-3p PEA15
miRBase
Accession/Entrez ID		 MIMAT0000759 8682
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HMAT1//HUMMAT1H//MAT1//MAT1H//PEA-15//PED//PED-PEA15//PED/PEA15

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-148b-3p
rs1202664554 chr12:54337294    C/A
rs553421594 chr12:54337296    T/G
rs74878365 chr12:54337287    C/A
rs760611163 chr12:54337286    T/C
rs767601064 chr12:54337280    A/C
rs773312042 chr12:54337285    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PEA15
chr1:160175263-160175264(+) m6A 5'UTR       24284625//24209618//24981863
chr1:160175270-160175271(+) m6A 5'UTR       24284625//24209618//24981863
chr1:160176968-160176969(+) m6A 5'UTR//intron       24284625//24209618//24981863
chr1:160178410-160178411(+) m6A CDS//intron       24209618
chr1:160178445-160178446(+) m6A CDS//intron       24209618
chr1:160181349-160181350(+) m6A CDS//exon       24209618//24981863
chr1:160181362-160181363(+) m6A CDS//exon       24209618//24981863
chr1:160181396-160181397(+) m6A CDS//exon       24209618//24981863
chr1:160181422-160181423(+) m6A CDS//exon       24209618//24981863
chr1:160181500-160181501(+) m6A CDS//exon//intron       24981863
chr1:160182976-160182977(+) m6A CDS//exon       24981863
chr1:160183013-160183014(+) m6A CDS//exon       24981863
chr1:160183305-160183306(+) m6A 3'UTR//exon       26404942
chr1:160183630-160183631(+) m6A 3'UTR       24981863
chr1:160183726-160183727(+) m6A 3'UTR       24981863
chr1:160184159-160184160(+) m6A 3'UTR       -
chr1:160184236-160184237(+) m6A 3'UTR       -
chr1:160184249-160184250(+) m6A 3'UTR       -
chr1:160184289-160184290(+) m6A 3'UTR       -
chr1:160184417-160184418(+) m6A 3'UTR       24981863
chr1:160184543-160184544(+) m6A 3'UTR       24981863
chr1:160184568-160184569(+) m6A 3'UTR       24981863
chr1:160184595-160184596(+) m6A 3'UTR       24981863//26404942
chr1:160184604-160184605(+) m6A 3'UTR       26404942
chr1:160184644-160184645(+) m6A 3'UTR       26404942
chr1:160184900-160184901(+) m6A 3'UTR       26404942
chr1:160184984-160184985(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-148b-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     19951903
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PEA15
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-148b-3p
Sensorad 99342 Drug sensitive
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug resistant
CID 9604911 9604911 Drug resistant
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
o-Aminoazotoluene 7340 Drug sensitive
Dihydroartemisinyl ether, stereoisomer of NSC-685988 6712440 Drug sensitive
Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive
Lanatoside C 656630 Drug sensitive
Neocuproine 65237 Drug sensitive
Chalcone analog 6296717 Drug sensitive
Daunorubicin hydrochloride 62770 Drug sensitive
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug sensitive
Antibiotic 1907-VIII 5477807 Drug sensitive
Cystothiazole A 5470965 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug resistant
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
Varacin trifluoroacetate salt 54611558 Drug sensitive
Curromycin A.B mixture 54608021 Drug sensitive
Antineoplastic-328785 54607693 Drug sensitive
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
1-[3-(Propylamino)phenyl]-N-(pyridin-4-ylmethylideneamino)pyrazolo[3,4-d]pyrimidin-4-amine 53239979 Drug resistant
Kekule 499328 Drug sensitive
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
6-Bromosangivamycin 470030 Drug sensitive
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug sensitive
BAS100 Monohydrate 45028404 Drug sensitive
Trichopolyn 431962 Drug sensitive
5-(Chloromethyl)quinolin-8-ol 416881 Drug sensitive
(-)-Dibenzylnortrachelogenin 405098 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
Mechlorethamine 4033 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamine 398148 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Asimicinone 393461 Drug sensitive
2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug sensitive
5,8-Quinolinedione, 2-methyl- 388305 Drug sensitive
Sampangine 387195 Drug sensitive
N,N-Bis(2-chloropropyl)-N-methylammonium chloride 381678 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug resistant
Thiosangivamycin 3580213 Drug sensitive
Nicomol 34081 Drug sensitive
Buellolide 337850 Drug sensitive
Predorine 333830 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
6-Bromotoyocamycin 270861 Drug sensitive
Scillirosidin, glycoside 222160 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
4-Oxo-4-[[(13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid 146160078 Drug sensitive
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug sensitive
43-Dioxypectenotoxin 131751434 Drug resistant
Astraphloxin 12299852 Drug sensitive
Capri Blue 102162 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug resistant
(-)-furodysinin - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
arabinofuranosyl cytosine 5'-oleyl phosphate monosodium, - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
antineoplastic-654376 - Drug sensitive
antineoplastic-654379 - Drug sensitive
leucinostatine d - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-148b-3p
Formaldehyde 712 Drug interaction    RC00004410
Oxaliplatine 6857599 Drug interaction    RC00004418
Gemcitabine 60750 Drug interaction    RC00004415
Imatinib 5291 Drug interaction    RC00004413
5-Fluorouracil 3385 Drug interaction    RC00004412
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004411
Tamoxifen 2733526 Drug interaction    RC00004417
Navitoclax 24978538 Drug interaction    RC00004419
Sorafenib 216239 Drug interaction    RC00004416
Arsenic trioxide 14888 Drug interaction    RC00004414
Leucovorin 135403648 Drug interaction    RC00004420
Medpor - Drug interaction    RC00004422
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004421

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-148b-3p
Interactor2: PEA15

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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