Detail Information

Basic Information:


  VIRBase ID:  

HHID00057229

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-378a-5p:           RHEBL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-378a-5p RHEBL1
miRBase
Accession/Entrez ID		 MIMAT0000731 121268
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RHEBL1c

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-378a-5p
rs1195025900 chr5:149732846    T/A
rs1329713344 chr5:149732828    GC/G
rs1361372361 chr5:149732844    C/T
rs1457638573 chr5:149732841    GGTCCTGT/G
rs781166851 chr5:149732847    G/T
rs951679960 chr5:149732840    A/T
rs1375418377 chr5:149732827    GGCTCCTGACTCCAGGT/G
rs1387429942 chr5:149732833    T/A
rs376185067 chr5:149732836    C/G
rs979812780 chr5:149732831    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RHEBL1
chr12:49462302(-) A-I      intronic
chr12:49461480(-) A-I      intronic
chr12:49462316(-) A-I      intronic
chr12:49462324(-) A-I      intronic
chr12:49461419(-) A-I      intronic
chr12:49461382(-) A-I      intronic
chr12:49461470(-) A-I      intronic
chr12:49461511(-) A-I      intronic
chr12:49461560(-) A-I      intronic
chr12:49462009(-) A-I      intronic
chr12:49462287(-) A-I      intronic
chr12:49462301(-) A-I      intronic
chr12:49462303(-) A-I      intronic
chr12:49462304(-) A-I      intronic
chr12:49462092(-) A-I      intronic
chr12:49461344(-) A-I      intronic
chr12:49461506(-) A-I      intronic
chr12:49461303(-) A-I      intronic
chr12:49461178(-) A-I      intronic
chr12:49462356(-) A-I      intronic
chr12:49461141(-) A-I      intronic
chr12:49462010(-) A-I      intronic
chr12:49462338(-) A-I      intronic
chr12:49462077(-) A-I      intronic
chr12:49460983(-) A-I      intronic
chr12:49462286(-) A-I      intronic
chr12:49460982(-) A-I      intronic
chr12:49462474(-) A-I      intronic
chr12:49462401(-) A-I      intronic
chr12:49461516(-) A-I      intronic
chr12:49461305(-) A-I      intronic
chr12:49461207(-) A-I      intronic
chr12:49462383(-) A-I      intronic
chr12:49461085(-) A-I      intronic
chr12:49462334(-) A-I      intronic
chr12:49461359(-) A-I      intronic
chr12:49460989(-) A-I      intronic
chr12:49462093(-) A-I      intronic
chr12:49461201(-) A-I      intronic
chr12:49461435(-) A-I      intronic
chr12:49461441(-) A-I      intronic
chr12:49461559(-) A-I      intronic
chr12:49462050(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RHEBL1
chr12:49461207(-) A-G intron -    22484847
chr12:49461516(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RHEBL1
chr12:49458532-49458533(-) m6A 3'UTR       27773535
chr12:49458584-49458585(-) m6A 3'UTR       27773535
chr12:49458674-49458675(-) m6A 3'UTR       24209618//27773535
chr12:49458685-49458686(-) m6A 3'UTR       24209618//27773535
chr12:49458767-49458768(-) m6A 3'UTR       24284625
chr12:49458808-49458809(-) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-378a-5p
Exosome Plasma     29323722
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Serum     24797360
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
RHEBL1
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-378a-5p
Interactor2: RHEBL1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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