Detail Information

Basic Information:


  VIRBase ID:  

HHID00057195

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-5p:           TXLNB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-374a-5p TXLNB
miRBase
Accession/Entrez ID		 MIMAT0000727 167838
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C6orf198//dJ522B19.2//LST001//MDP77

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-374a-5p
rs1220488786 chrX:74287329    T/C
rs1360532268 chrX:74287325    C/T
rs753639076 chrX:74287331    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TXLNB
chr6:139589204(-) A-I      intronic
chr6:139589171(-) A-I      intronic
chr6:139589201(-) A-I      intronic
chr6:139589176(-) A-I      intronic
chr6:139589170(-) A-I      intronic
chr6:139581230(-) A-I      intronic
chr6:139581289(-) A-I      intronic
chr6:139594014(-) A-I      intronic
chr6:139594726(-) A-I      intronic
chr6:139568506(-) A-I      intronic
chr6:139574077(-) A-I      intronic
chr6:139576979(-) A-I      intronic
chr6:139594889(-) A-I      intronic
chr6:139577470(-) A-I      intronic
chr6:139577527(-) A-I      intronic
chr6:139577534(-) A-I      intronic
chr6:139577668(-) A-I      intronic
chr6:139577740(-) A-I      intronic
chr6:139577756(-) A-I      intronic
chr6:139594890(-) A-I      intronic
chr6:139605602(-) A-I      intronic
chr6:139605605(-) A-I      intronic
chr6:139567964(-) A-I      intronic
chr6:139581101(-) A-I      intronic
chr6:139567965(-) A-I      intronic
chr6:139567951(-) A-I      intronic
chr6:139567968(-) A-I      intronic
chr6:139567969(-) A-I      intronic
chr6:139571377(-) A-I      intronic
chr6:139568327(-) A-I      intronic
chr6:139568342(-) A-I      intronic
chr6:139569430(-) A-I      intronic
chr6:139571284(-) A-I      intronic
chr6:139569439(-) A-I      intronic
chr6:139577559(-) A-I      intronic
chr6:139577563(-) A-I      intronic
chr6:139581188(-) A-I      intronic
chr6:139581180(-) A-I      intronic
chr6:139590110(-) A-I      intronic
chr6:139568461(-) A-I      intronic
chr6:139568482(-) A-I      intronic
chr6:139581351(-) A-I      intronic
chr6:139567013(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TXLNB
chr6:139568461(-) A-G intron -    22484847
chr6:139577559(-) A-G intron -    22484847
chr6:139581180(-) A-G intron -    22484847
chr6:139581203(-) A-G intron -    22484847
chr6:139581250(-) A-G intron -    22484847
chr6:139581351(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TXLNB
chr6:139564150-139564151(-) m6A CDS       27773535
chr6:139564225-139564226(-) m6A CDS       27773535
chr6:139564358-139564359(-) m6A CDS       27773535//22608085
chr6:139564392-139564393(-) m6A CDS       27773535//22608085
chr6:139565744-139565745(-) m6A CDS       -
chr6:139565765-139565766(-) m6A CDS       -
chr6:139568957-139568958(-) m6A CDS       27773535
chr6:139568968-139568969(-) m6A CDS       27773535
chr6:139581544-139581545(-) m6A CDS       27773535
chr6:139581553-139581554(-) m6A CDS       27773535
chr6:139581566-139581567(-) m6A CDS       27773535
chr6:139583773-139583774(-) m6A CDS       27773535
chr6:139583830-139583831(-) m6A CDS       27773535
chr6:139591600-139591601(-) m6A CDS       -
chr6:139591610-139591611(-) m6A CDS       -
chr6:139609700-139609701(-) m6A CDS       27773535
chr6:139609723-139609724(-) m6A CDS       27773535//22608085
chr6:139609734-139609735(-) m6A CDS       27773535//22608085
chr6:139609842-139609843(-) m6A CDS       -
chr6:139610015-139610016(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-374a-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Plasma|Serum     24683445
Exosome Seminal fluid     -
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
Nucleus Neural progenitor cells     21363885
TXLNB
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-374a-5p
Antibiotic 1907-VIII 5477807 Drug sensitive
2-Methylolivacinium acetate 5458752 Drug sensitive
Epidoxoform 46877760 Drug sensitive
5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug sensitive
Mitoxantrone 4212 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
3-(Dimethylamino)-7-(methylamino)phenothiazin-5-ium bromide 13797451 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
Epilactose 128037 Drug resistant
Unii-6FH145297U 11541062 Drug sensitive
Pararosaniline hydrochloride 11292 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Capri Blue 102162 Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive
phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug sensitive
Basic Fuchsin - Drug sensitive
from cephalodiscus gilchristi - Drug sensitive
leucinostatine d - Drug sensitive
methyl green - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-374a-5p
Curcumin 969516 Drug interaction    RC00004182
Cianidanol 9064 Drug interaction    RC00004174
Formaldehyde 712 Drug interaction    RC00004169
Alocrest 60780 Drug interaction    RC00004177
Progesterone 5994 Drug interaction    RC00004173
Ferulic acid 445858 Drug interaction    RC00004181
Naringin 442428 Drug interaction    RC00004180
Paclitaxel 36314 Drug interaction    RC00004176
Doxorubicin 31703 Drug interaction    RC00004175
Valproic acid 3121 Drug interaction    RC00004172
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004171
Tamoxifen 2733526 Drug interaction    RC00004183
Verapamil 2520 Drug interaction    RC00004170
Gefitinib 123631 Drug interaction    RC00004179
Proanthocyanidin 108065 Drug interaction    RC00004178
Marine fungal metabolite 1386A - Drug interaction    RC00004184

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-374a-5p
Interactor2: TXLNB

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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