Basic Information:

  VIRBase ID:  

HHID00057063

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-5p:  MIMAT0000727          TRAF6:  NM_145803     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-5p	TRAF6
miRBase Accession/Entrez ID	MIMAT0000727	7189
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MGC:3310//RNF85

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-5p	rs1220488786 chrX:74287329    T/C rs1360532268 chrX:74287325    C/T rs753639076 chrX:74287331    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRAF6	chr11:36517280(-) A-I      intronic chr11:36508627(-) A-I      3'UTR chr11:36517294(-) A-I      intronic chr11:36517293(-) A-I      intronic chr11:36508584(-) A-I      3'UTR chr11:36508578(-) A-I      3'UTR chr11:36508608(-) A-I      3'UTR chr11:36508633(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRAF6	chr11:36508559(-) A-I exon 3'UTR    22327324 chr11:36507686(-) A-G exon 3'UTR    21725310   //22484847 chr11:36507861(-) A-G exon 3'UTR    21725310   //22484847 chr11:36507641(-) C-A exon 3'UTR    22484847 chr11:36507687(-) A-G exon 3'UTR    22484847 chr11:36507777(-) A-G exon 3'UTR    22484847 chr11:36507807(-) A-G exon 3'UTR    22484847 chr11:36507820(-) A-G exon 3'UTR    22484847 chr11:36508454(-) A-G exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRAF6	chr11:36511310-36511311(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr11:36511348-36511349(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr11:36511365-36511366(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr11:36511500-36511501(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:36511507-36511508(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr11:36511556-36511557(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:36511597-36511598(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr11:36511622-36511623(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr11:36511742-36511743(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:36511792-36511793(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:36511804-36511805(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:36511843-36511844(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:36511940-36511941(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36511950-36511951(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36511959-36511960(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36511992-36511993(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36512027-36512028(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36512032-36512033(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:36512064-36512065(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr11:36512162-36512163(-) m6A CDS//exon       24209618//27773535 chr11:36514155-36514156(-) m6A CDS//exon       27773535 chr11:36516528-36516529(-) m6A CDS//exon       27773535 chr11:36516583-36516584(-) m6A CDS//exon       27773535 chr11:36517922-36517923(-) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma|Serum     24683445 Exosome Seminal fluid     - Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815 Nucleus Neural progenitor cells     21363885
	TRAF6	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-374a-5p	Antibiotic 1907-VIII 5477807 Drug sensitive 2-Methylolivacinium acetate 5458752 Drug sensitive Epidoxoform 46877760 Drug sensitive 5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug sensitive Mitoxantrone 4212 Drug sensitive Rogiolol 402519 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive 3-(Dimethylamino)-7-(methylamino)phenothiazin-5-ium bromide 13797451 Drug sensitive 12-Iminodaunorubicin hcl 135539784 Drug sensitive Epilactose 128037 Drug resistant Unii-6FH145297U 11541062 Drug sensitive Pararosaniline hydrochloride 11292 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Capri Blue 102162 Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug sensitive Basic Fuchsin - Drug sensitive from cephalodiscus gilchristi - Drug sensitive leucinostatine d - Drug sensitive methyl green - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-374a-5p	Curcumin 969516 Drug interaction    RC00004182 Cianidanol 9064 Drug interaction    RC00004174 Formaldehyde 712 Drug interaction    RC00004169 Alocrest 60780 Drug interaction    RC00004177 Progesterone 5994 Drug interaction    RC00004173 Ferulic acid 445858 Drug interaction    RC00004181 Naringin 442428 Drug interaction    RC00004180 Paclitaxel 36314 Drug interaction    RC00004176 Doxorubicin 31703 Drug interaction    RC00004175 Valproic acid 3121 Drug interaction    RC00004172 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004171 Tamoxifen 2733526 Drug interaction    RC00004183 Verapamil 2520 Drug interaction    RC00004170 Gefitinib 123631 Drug interaction    RC00004179 Proanthocyanidin 108065 Drug interaction    RC00004178 Marine fungal metabolite 1386A - Drug interaction    RC00004184

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-5p
Interactor2: TRAF6

Evidence Support:

Weak-Evidence	HITS-CLIP//PAR-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).