Basic Information:

  VIRBase ID:  

HHID00056960

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-302c-3p:  MIMAT0000717          POLE4:  NM_019896     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-302c-3p	POLE4
miRBase Accession/Entrez ID	MIMAT0000717	56655
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p12//YHHQ1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-302c-3p	rs369989762 chr4:112648368    A/G rs372333642 chr4:112648377    T/A rs372333642 chr4:112648377    T/C rs375011523 chr4:112648366    C/T rs762503340 chr4:112648373    A/C rs772656527 chr4:112648372    A/G rs1164833087 chr4:112648387    T/C rs1391170578 chr4:112648386    T/G rs199971565 chr4:112648383    CACTT/C rs749262875 chr4:112648387    T/TA rs751245335 chr4:112648383    C/G rs769821630 chr4:112648385    CTTACTT/C rs773129212 chr4:112648385    C/CT rs906647149 chr4:112648384    A/G rs936470649 chr4:112648381    A/G rs948247059 chr4:112648382    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	POLE4	chr2:75185856-75185857(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr2:75185985-75185986(+) m6A CDS//exon       24284625//24209618 chr2:75186139-75186140(+) m6A exon//intron       24284625 chr2:75186445-75186446(+) m6A exon//intron       - chr2:75186469-75186470(+) m6A CDS//exon       - chr2:75186482-75186483(+) m6A CDS//exon       - chr2:75186530-75186531(+) m6A CDS//exon       - chr2:75186546-75186547(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-302c-3p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	POLE4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-302c-3p
Interactor2: POLE4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.