Basic Information:

  VIRBase ID:  

HHID00056955

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-302c-3p:  MIMAT0000717          CROT:  NM_001243745     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-302c-3p	CROT
miRBase Accession/Entrez ID	MIMAT0000717	54677
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-302c-3p	rs369989762 chr4:112648368    A/G rs372333642 chr4:112648377    T/A rs372333642 chr4:112648377    T/C rs375011523 chr4:112648366    C/T rs762503340 chr4:112648373    A/C rs772656527 chr4:112648372    A/G rs1164833087 chr4:112648387    T/C rs1391170578 chr4:112648386    T/G rs199971565 chr4:112648383    CACTT/C rs749262875 chr4:112648387    T/TA rs751245335 chr4:112648383    C/G rs769821630 chr4:112648385    CTTACTT/C rs773129212 chr4:112648385    C/CT rs906647149 chr4:112648384    A/G rs936470649 chr4:112648381    A/G rs948247059 chr4:112648382    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CROT	chr7:86994555(+) A-I      intronic chr7:86985408(+) A-I      intronic chr7:86984699(+) A-I      intronic chr7:86984690(+) A-I      intronic chr7:86984533(+) A-I      intronic chr7:87001087(+) A-I      intronic chr7:86999556(+) A-I      intronic chr7:86999554(+) A-I      intronic chr7:87001098(+) A-I      intronic chr7:86999592(+) A-I      intronic chr7:87001148(+) A-I      intronic chr7:86999625(+) A-I      intronic chr7:87001195(+) A-I      intronic chr7:87001058(+) A-I      intronic chr7:86995067(+) A-I      intronic chr7:86985330(+) A-I      intronic chr7:86999761(+) A-I      intronic chr7:86985396(+) A-I      intronic chr7:86999734(+) A-I      intronic chr7:87028808(+) A-I      3'UTR chr7:87028672(+) A-I      3'UTR chr7:87028533(+) A-I      3'UTR chr7:86999632(+) A-I      intronic chr7:86999562(+) A-I      intronic chr7:87001205(+) A-I      intronic chr7:87001230(+) A-I      intronic chr7:86999560(+) A-I      intronic chr7:87001052(+) A-I      intronic chr7:86999599(+) A-I      intronic chr7:87001092(+) A-I      intronic chr7:86980356(+) A-I      intronic chr7:87001105(+) A-I      intronic chr7:87001155(+) A-I      intronic chr7:86999668(+) A-I      intronic chr7:87001235(+) A-I      intronic chr7:86999708(+) A-I      intronic chr7:86994991(+) A-I      intronic chr7:86995157(+) A-I      intronic chr7:86994993(+) A-I      intronic chr7:86994703(+) A-I      intronic chr7:87001152(+) A-I      intronic chr7:86999563(+) A-I      intronic chr7:86986177(+) A-I      intronic chr7:87001147(+) A-I      intronic chr7:87013087(+) A-I      intronic chr7:86999709(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CROT	chr7:87001052(+) A-I intron -    22327324 chr7:87001148(+) A-I intron -    21960545   //22327324 chr7:87001058(+) A-I intron -    21960545 chr7:86985330(+) A-G intron -    22484847 chr7:86986177(+) A-G intron -    22484847 chr7:86994703(+) A-G intron -    22484847 chr7:86994975(+) A-G intron -    22484847 chr7:86994993(+) A-G intron -    22484847 chr7:86995067(+) A-G intron -    22484847 chr7:86999562(+) A-G intron -    22484847 chr7:86999563(+) A-G intron -    22484847 chr7:86999599(+) A-G intron -    22484847 chr7:86999708(+) A-G intron -    22484847 chr7:86999709(+) A-G intron -    22484847 chr7:86999733(+) A-G intron -    22484847 chr7:86999734(+) A-G intron -    22484847 chr7:86999737(+) A-G intron -    22484847 chr7:87001051(+) A-G intron -    22484847 chr7:87001058(+) A-G intron -    22484847 chr7:87001091(+) A-G intron -    22484847 chr7:87001092(+) A-G intron -    22484847 chr7:87001098(+) A-G intron -    22484847 chr7:87001145(+) A-G intron -    22484847 chr7:87001147(+) A-G intron -    22484847 chr7:87001148(+) A-G intron -    22484847 chr7:87001173(+) A-G intron -    22484847 chr7:87001235(+) A-G intron -    22484847 chr7:87001265(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CROT	chr7:86975079-86975080(+) m6A 5'UTR       24981863 chr7:86975689-86975690(+) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-302c-3p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CROT	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-302c-3p
Interactor2: CROT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.