Basic Information:

  VIRBase ID:  

HHID00056596

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-363-3p:  MIMAT0000707          RSBN1:  NR_130896     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-363-3p	RSBN1
miRBase Accession/Entrez ID	MIMAT0000707	54665
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KDM9//ROSBIN

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-363-3p	rs1266322921 chrX:134169384    C/T rs370757353 chrX:134169385    A/G rs374421612 chrX:134169395    C/T rs746918584 chrX:134169396    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RSBN1	chr1:114318172(-) A-I      intronic chr1:114316459(-) A-I      intronic chr1:114318160(-) A-I      intronic chr1:114318153(-) A-I      intronic chr1:114318152(-) A-I      intronic chr1:114318137(-) A-I      intronic chr1:114318011(-) A-I      intronic chr1:114318132(-) A-I      intronic chr1:114317997(-) A-I      intronic chr1:114317993(-) A-I      intronic chr1:114317966(-) A-I      intronic chr1:114317954(-) A-I      intronic chr1:114317963(-) A-I      intronic chr1:114317961(-) A-I      intronic chr1:114317958(-) A-I      intronic chr1:114318178(-) A-I      intronic chr1:114318177(-) A-I      intronic chr1:114318175(-) A-I      intronic chr1:114316541(-) A-I      intronic chr1:114316563(-) A-I      intronic chr1:114316525(-) A-I      intronic chr1:114316038(-) A-I      intronic chr1:114316468(-) A-I      intronic chr1:114316083(-) A-I      intronic chr1:114316024(-) A-I      intronic chr1:114320983(-) A-I      intronic chr1:114346490(-) A-I      intronic chr1:114318231(-) A-I      intronic chr1:114346504(-) A-I      intronic chr1:114318155(-) A-I      intronic chr1:114316053(-) A-I      intronic chr1:114318154(-) A-I      intronic chr1:114318141(-) A-I      intronic chr1:114317840(-) A-I      intronic chr1:114347907(-) A-I      intronic chr1:114317850(-) A-I      intronic chr1:114321064(-) A-I      intronic chr1:114346688(-) A-I      intronic chr1:114315902(-) A-I      intronic chr1:114316062(-) A-I      intronic chr1:114320993(-) A-I      intronic chr1:114336375(-) A-I      intronic chr1:114318127(-) A-I      intronic chr1:114347895(-) A-I      intronic chr1:114344815(-) A-I      intronic chr1:114335210(-) A-I      intronic chr1:114318056(-) A-I      intronic chr1:114344791(-) A-I      intronic chr1:114317994(-) A-I      intronic chr1:114317177(-) A-I      intronic chr1:114315979(-) A-I      intronic chr1:114316392(-) A-I      intronic chr1:114343674(-) A-I      intronic chr1:114335128(-) A-I      intronic chr1:114348900(-) A-I      intronic chr1:114345898(-) A-I      intronic chr1:114345903(-) A-I      intronic chr1:114347811(-) A-I      intronic chr1:114318092(-) A-I      intronic chr1:114321057(-) A-I      intronic chr1:114347828(-) A-I      intronic chr1:114319332(-) A-I      intronic chr1:114347921(-) A-I      intronic chr1:114346682(-) A-I      intronic chr1:114345907(-) A-I      intronic chr1:114346709(-) A-I      intronic chr1:114317784(-) A-I      intronic chr1:114318238(-) A-I      intronic chr1:114317851(-) A-I      intronic chr1:114318088(-) A-I      intronic chr1:114318101(-) A-I      intronic chr1:114315929(-) A-I      intronic chr1:114317920(-) A-I      intronic chr1:114320986(-) A-I      intronic chr1:114318123(-) A-I      intronic chr1:114347906(-) A-I      intronic chr1:114316034(-) A-I      intronic chr1:114346669(-) A-I      intronic chr1:114315983(-) A-I      intronic chr1:114317823(-) A-I      intronic chr1:114346468(-) A-I      intronic chr1:114317826(-) A-I      intronic chr1:114317926(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RSBN1	chr1:114316034(-) A-G intron -    22484847 chr1:114317177(-) A-G intron -    22484847 chr1:114317850(-) A-G intron -    22484847 chr1:114317851(-) A-G intron -    22484847 chr1:114317926(-) A-G intron -    22484847 chr1:114318088(-) A-G intron -    22484847 chr1:114318101(-) A-G intron -    22484847 chr1:114318238(-) A-G intron -    22484847 chr1:114347906(-) A-G intron -    22484847 chr1:114348900(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RSBN1	chr1:114305313-114305314(-) m6A 3'UTR       27773535 chr1:114305318-114305319(-) m6A 3'UTR       27773535 chr1:114306765-114306766(-) m6A 3'UTR       27773535 chr1:114306781-114306782(-) m6A 3'UTR       27773535 chr1:114306924-114306925(-) m6A 3'UTR       27773535 chr1:114306950-114306951(-) m6A 3'UTR       27773535 chr1:114308083-114308084(-) Y 3'UTR       26075521 chr1:114308585-114308586(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr1:114308622-114308623(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr1:114308650-114308651(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr1:114308655-114308656(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr1:114308690-114308691(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:114308715-114308716(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr1:114308789-114308790(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr1:114308848-114308849(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:114308872-114308873(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:114308904-114308905(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:114308948-114308949(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr1:114340013-114340014(-) m6A CDS       24284625//24981863//27773535//22608085 chr1:114340081-114340082(-) m6A CDS       24284625//24981863//27773535//22608085 chr1:114340090-114340091(-) m6A CDS       24284625//24981863//27773535//22608085 chr1:114340224-114340225(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr1:114340272-114340273(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr1:114340307-114340308(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr1:114340335-114340336(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr1:114340358-114340359(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr1:114340416-114340417(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr1:114340452-114340453(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr1:114340473-114340474(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr1:114340523-114340524(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr1:114340567-114340568(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr1:114340578-114340579(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr1:114340634-114340635(-) m6A CDS       24981863//27773535//27371828//22608085 chr1:114340655-114340656(-) m6A CDS       27773535//27371828//22608085 chr1:114354367-114354368(-) m6A CDS       27773535//27371828 chr1:114354390-114354391(-) m6A CDS       27773535//27371828 chr1:114354409-114354410(-) m6A CDS       27773535//27371828 chr1:114354809-114354810(-) m6A CDS//intron       25456834//24981863//27371828 chr1:114354828-114354829(-) m6A CDS//intron       25456834//24981863//27371828 chr1:114354983-114354984(-) m6A CDS       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-363-3p	Cytoplasm Neural progenitor cells     21363885 Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	RSBN1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-363-3p	Tetrangulol 99188 Drug sensitive Azacitidine 9444 Drug resistant Coptisine chloride 72321 Drug sensitive Tolonium chloride 7083 Drug sensitive Azure B 68275 Drug sensitive 3-Hydroxy-N-1-naphthyl-2-naphthamide 67241 Drug sensitive Psammaplin A 6400741 Drug sensitive Methylene blue 6099 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Adenosine, 2-bromo-2'-deoxy- 55914 Drug sensitive 11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant (E)-1-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)prop-2-en-1-one 5469981 Drug resistant Bleomycin 5460769 Drug resistant Indanthren Corinth RK 5351878 Drug sensitive N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug resistant 5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Vorinostat 5311 Drug sensitive Elsinochrome C 495866 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Itraconazole, 99% 45039617 Drug resistant 9-beta-D-Xylofuranosyladenine 447916 Drug resistant Latrunculin a 445420 Drug resistant 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant 2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Bleomycin A5, sulfate 422920 Drug resistant N-Benzyl-5-chloropyrazine-2-carboxamide 406085 Drug sensitive Menadione 4055 Drug sensitive Rogiolol 402519 Drug sensitive 1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive Kuanoniamine A 390989 Drug sensitive Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive 7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive 5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Miltefosine 3599 Drug resistant 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive 6,7-Diacetoxyisoflavan 353129 Drug sensitive Helenin 327378 Drug sensitive Dasatinib 3062316 Drug resistant Phenanthrene-9,10-diimine 2981 Drug sensitive (15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive Estramustine 259331 Drug sensitive Isoindolo[2,1-a]quinoxaline-6(5H)-one 24205090 Drug resistant (-)-Leucascandrolide A 24203380 Drug resistant 1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive 1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug resistant 4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant 3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug resistant Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive 6-Aryl-pyrazolo[3,4-b]pyridine analogue 13 135435011 Drug resistant Discorhabdin B 135409044 Drug sensitive Purpurogallin 135403797 Drug sensitive Mercury, (4-aminophenyl)(6-thioguanosinato-N7,S6)- 135403617 Drug sensitive Allopurinol 135401907 Drug resistant Halomon 132430 Drug resistant 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-Deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside 132274946 Drug resistant Dibutyltin dichloride 12688 Drug sensitive 15-Deacetylsergeolide 125729 Drug sensitive Benzoanthracenone 12300036 Drug resistant Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Chimaphilin 101211 Drug sensitive antineoplastic-d655481 - Drug resistant bengamide g - Drug resistant Carboqone; Carbazilquinone - Drug resistant michicarcin - Drug resistant protein: pa30-14 - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant tp4ek-k6 - Drug resistant 1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug sensitive 3,3'-diamino-4,4'-bis(dimethylamino)benzophenone - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 6-(4-ethylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive 7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive 9-cis-retinol,palmitic acid ester - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive dichloro(dodeca-2,6,10-triene-1,12-diyl)- ruthenium - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive 2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive 3-farnesylthiopropionamide - Drug sensitive antineoplastic-d183258 - Drug sensitive chlorambucil-spermidine - Drug sensitive crambescidin 800 trihydrochloride - Drug sensitive hymenialdisine - Drug sensitive potassium arsenite - Drug sensitive rh(iii)-amodiaquine - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-363-3p	Formaldehyde 712 Drug interaction    RC00004045 Alocrest 60780 Drug interaction    RC00004053 Eloxatine 5310940 Drug interaction    RC00004055 Paroxetine 43815 Drug interaction    RC00004052 Idarubicin 42890 Drug interaction    RC00004057 Paclitaxel 36314 Drug interaction    RC00004051 5-Fluorouracil 3385 Drug interaction    RC00004049 Emodin 3220 Drug interaction    RC00004048 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004047 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004056 Bicalutamide 2375 Drug interaction    RC00004046 Arsenic trioxide 14888 Drug interaction    RC00004050 Docetaxel 148124 Drug interaction    RC00004054 Chemotherapy - Drug interaction    RC00008855

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-363-3p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-363-3p
Interactor2: RSBN1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.