Detail Information

Basic Information:


  VIRBase ID:  

HHID00056585

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-363-3p:           ERGIC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-363-3p ERGIC2
miRBase
Accession/Entrez ID		 MIMAT0000707 51290
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - cd002//CDA14//Erv41//PTX1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-363-3p
rs1266322921 chrX:134169384    C/T
rs370757353 chrX:134169385    A/G
rs374421612 chrX:134169395    C/T
rs746918584 chrX:134169396    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ERGIC2
chr12:29499291(-) A-I      intronic
chr12:29495219(-) A-I      intronic
chr12:29499290(-) A-I      intronic
chr12:29498626(-) A-I      intronic
chr12:29495173(-) A-I      intronic
chr12:29525869(-) A-I      intronic
chr12:29525789(-) A-I      intronic
chr12:29525600(-) A-I      intronic
chr12:29509138(-) A-I      intronic
chr12:29509135(-) A-I      intronic
chr12:29509131(-) A-I      intronic
chr12:29509092(-) A-I      intronic
chr12:29505616(-) A-I      intronic
chr12:29505514(-) A-I      intronic
chr12:29505461(-) A-I      intronic
chr12:29505439(-) A-I      intronic
chr12:29505430(-) A-I      intronic
chr12:29505370(-) A-I      intronic
chr12:29499396(-) A-I      intronic
chr12:29499194(-) A-I      intronic
chr12:29525200(-) A-I      intronic
chr12:29499260(-) A-I      intronic
chr12:29509052(-) A-I      intronic
chr12:29499250(-) A-I      intronic
chr12:29499285(-) A-I      intronic
chr12:29498629(-) A-I      intronic
chr12:29505448(-) A-I      intronic
chr12:29495006(-) A-I      intronic
chr12:29505564(-) A-I      intronic
chr12:29499187(-) A-I      intronic
chr12:29499398(-) A-I      intronic
chr12:29498713(-) A-I      intronic
chr12:29499289(-) A-I      intronic
chr12:29499350(-) A-I      intronic
chr12:29505555(-) A-I      intronic
chr12:29505561(-) A-I      intronic
chr12:29498709(-) A-I      intronic
chr12:29505458(-) A-I      intronic
chr12:29499246(-) A-I      intronic
chr12:29498707(-) A-I      intronic
chr12:29505521(-) A-I      intronic
chr12:29498602(-) A-I      intronic
chr12:29494533(-) A-I      intronic
chr12:29505433(-) A-I      intronic
chr12:29509134(-) A-I      intronic
chr12:29498590(-) A-I      intronic
chr12:29525729(-) A-I      intronic
chr12:29498731(-) A-I      intronic
chr12:29525848(-) A-I      intronic
chr12:29525625(-) A-I      intronic
chr12:29495109(-) A-I      intronic
chr12:29509175(-) A-I      intronic
chr12:29494468(-) A-I      intronic
chr12:29509119(-) A-I      intronic
chr12:29499299(-) A-I      intronic
chr12:29505475(-) A-I      intronic
chr12:29509047(-) A-I      intronic
chr12:29498833(-) A-I      intronic
chr12:29498730(-) A-I      intronic
chr12:29498839(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ERGIC2
chr12:29493734(-) A-I exon 3'UTR    22327324
chr12:29495109(-) A-G intron -    22484847
chr12:29498602(-) A-G intron -    22484847
chr12:29498707(-) A-G intron -    22484847
chr12:29498730(-) A-G intron -    22484847
chr12:29498839(-) A-G intron -    22484847
chr12:29499246(-) A-G intron -    22484847
chr12:29499260(-) A-G intron -    22484847
chr12:29499285(-) A-G intron -    22484847
chr12:29499289(-) A-G intron -    22484847
chr12:29499350(-) A-G intron -    22484847
chr12:29499398(-) A-G intron -    22484847
chr12:29505433(-) A-G intron -    22484847
chr12:29505448(-) A-G intron -    22484847
chr12:29505458(-) A-G intron -    22484847
chr12:29505521(-) A-G intron -    22484847
chr12:29505561(-) A-G intron -    22484847
chr12:29509047(-) A-G intron -    22484847
chr12:29525200(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ERGIC2
chr12:29492215-29492216(-) m6A 3'UTR       27773535
chr12:29492238-29492239(-) m6A 3'UTR       27773535
chr12:29492280-29492281(-) m6A 3'UTR       27773535
chr12:29492666-29492667(-) m6A 3'UTR       27773535
chr12:29492675-29492676(-) m6A 3'UTR       27773535
chr12:29492734-29492735(-) m6A 3'UTR       27773535
chr12:29492762-29492763(-) m6A 3'UTR       27773535
chr12:29492770-29492771(-) m6A 3'UTR       27773535
chr12:29492794-29492795(-) m6A 3'UTR       27773535
chr12:29493631-29493632(-) m6A 3'UTR       27773535
chr12:29493641-29493642(-) m6A 3'UTR       27773535
chr12:29493652-29493653(-) m6A 3'UTR       27773535
chr12:29493722-29493723(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493746-29493747(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493789-29493790(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493933-29493934(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493939-29493940(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493977-29493978(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29493994-29493995(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494043-29494044(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494050-29494051(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494064-29494065(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494125-29494126(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494678-29494679(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494693-29494694(-) m6A 3'UTR//CDS//exon       27773535
chr12:29494766-29494767(-) m6A exon//intron       27773535
chr12:29534033-29534034(-) m6A 5'UTR//intron       24981863
chr12:29534059-29534060(-) m6A 5'UTR       24981863
chr12:29534077-29534078(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-363-3p
Cytoplasm Neural progenitor cells     21363885
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Seminal fluid     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
ERGIC2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-363-3p
Tetrangulol 99188 Drug sensitive
Azacitidine 9444 Drug resistant
Coptisine chloride 72321 Drug sensitive
Tolonium chloride 7083 Drug sensitive
Azure B 68275 Drug sensitive
3-Hydroxy-N-1-naphthyl-2-naphthamide 67241 Drug sensitive
Psammaplin A 6400741 Drug sensitive
Methylene blue 6099 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Adenosine, 2-bromo-2'-deoxy- 55914 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
(E)-1-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)prop-2-en-1-one 5469981 Drug resistant
Bleomycin 5460769 Drug resistant
Indanthren Corinth RK 5351878 Drug sensitive
N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug resistant
5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive
7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant
Vorinostat 5311 Drug sensitive
Elsinochrome C 495866 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
Itraconazole, 99% 45039617 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
Latrunculin a 445420 Drug resistant
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Bleomycin A5, sulfate 422920 Drug resistant
N-Benzyl-5-chloropyrazine-2-carboxamide 406085 Drug sensitive
Menadione 4055 Drug sensitive
Rogiolol 402519 Drug sensitive
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive
Kuanoniamine A 390989 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
(-)7,8-Dihydrocalanolide A 383107 Drug sensitive
19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Miltefosine 3599 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
6,7-Diacetoxyisoflavan 353129 Drug sensitive
Helenin 327378 Drug sensitive
Dasatinib 3062316 Drug resistant
Phenanthrene-9,10-diimine 2981 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
Estramustine 259331 Drug sensitive
Isoindolo[2,1-a]quinoxaline-6(5H)-one 24205090 Drug resistant
(-)-Leucascandrolide A 24203380 Drug resistant
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug resistant
4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant
3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug resistant
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
6-Aryl-pyrazolo[3,4-b]pyridine analogue 13 135435011 Drug resistant
Discorhabdin B 135409044 Drug sensitive
Purpurogallin 135403797 Drug sensitive
Mercury, (4-aminophenyl)(6-thioguanosinato-N7,S6)- 135403617 Drug sensitive
Allopurinol 135401907 Drug resistant
Halomon 132430 Drug resistant
2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-Deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside 132274946 Drug resistant
Dibutyltin dichloride 12688 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
Benzoanthracenone 12300036 Drug resistant
Melampodinin 11953936 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
Chimaphilin 101211 Drug sensitive
antineoplastic-d655481 - Drug resistant
bengamide g - Drug resistant
Carboqone; Carbazilquinone - Drug resistant
michicarcin - Drug resistant
protein: pa30-14 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
tp4ek-k6 - Drug resistant
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug sensitive
3,3'-diamino-4,4'-bis(dimethylamino)benzophenone - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
6-(4-ethylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive
9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive
9-cis-retinol,palmitic acid ester - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
dichloro(dodeca-2,6,10-triene-1,12-diyl)- ruthenium - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive
3-farnesylthiopropionamide - Drug sensitive
antineoplastic-d183258 - Drug sensitive
chlorambucil-spermidine - Drug sensitive
crambescidin 800 trihydrochloride - Drug sensitive
hymenialdisine - Drug sensitive
potassium arsenite - Drug sensitive
rh(iii)-amodiaquine - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-363-3p
Formaldehyde 712 Drug interaction    RC00004045
Alocrest 60780 Drug interaction    RC00004053
Eloxatine 5310940 Drug interaction    RC00004055
Paroxetine 43815 Drug interaction    RC00004052
Idarubicin 42890 Drug interaction    RC00004057
Paclitaxel 36314 Drug interaction    RC00004051
5-Fluorouracil 3385 Drug interaction    RC00004049
Emodin 3220 Drug interaction    RC00004048
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004047
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004056
Bicalutamide 2375 Drug interaction    RC00004046
Arsenic trioxide 14888 Drug interaction    RC00004050
Docetaxel 148124 Drug interaction    RC00004054
Chemotherapy - Drug interaction    RC00008855
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-363-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-363-3p
Interactor2: ERGIC2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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