Basic Information:

  VIRBase ID:  

HHID00056521

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-363-3p:  MIMAT0000707          NF2:  NR_156186     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-363-3p	NF2
miRBase Accession/Entrez ID	MIMAT0000707	4771
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACN//BANF//merlin-1//SCH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-363-3p	rs1266322921 chrX:134169384    C/T rs370757353 chrX:134169385    A/G rs374421612 chrX:134169395    C/T rs746918584 chrX:134169396    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NF2	chr22:30042856(+) A-I      intronic chr22:30082371(+) A-I      intronic chr22:30075659(+) A-I      intronic chr22:30081634(+) A-I      intronic chr22:30042862(+) A-I      intronic chr22:30042823(+) A-I      intronic chr22:30042837(+) A-I      intronic chr22:30081629(+) A-I      intronic chr22:30081306(+) A-I      intronic chr22:30081226(+) A-I      intronic chr22:30076301(+) A-I      intronic chr22:30076275(+) A-I      intronic chr22:30076248(+) A-I      intronic chr22:30076137(+) A-I      intronic chr22:30075800(+) A-I      intronic chr22:30075654(+) A-I      intronic chr22:30075631(+) A-I      intronic chr22:30075601(+) A-I      intronic chr22:30068406(+) A-I      intronic chr22:30063368(+) A-I      intronic chr22:30063366(+) A-I      intronic chr22:30063353(+) A-I      intronic chr22:30062330(+) A-I      intronic chr22:30049354(+) A-I      intronic chr22:30049042(+) A-I      intronic chr22:30048411(+) A-I      intronic chr22:30048374(+) A-I      intronic chr22:30048358(+) A-I      intronic chr22:30048355(+) A-I      intronic chr22:30046752(+) A-I      intronic chr22:30044686(+) A-I      intronic chr22:30044667(+) A-I      intronic chr22:30042800(+) A-I      intronic chr22:30020358(+) A-I      intronic chr22:30016784(+) A-I      intronic chr22:30016572(+) A-I      intronic chr22:30016479(+) A-I      intronic chr22:30015560(+) A-I      intronic chr22:30015546(+) A-I      intronic chr22:30013178(+) A-I      intronic chr22:30012686(+) A-I      intronic chr22:30012620(+) A-I      intronic chr22:30012611(+) A-I      intronic chr22:30010424(+) A-I      intronic chr22:30010270(+) A-I      intronic chr22:30010269(+) A-I      intronic chr22:30009937(+) A-I      intronic chr22:30009309(+) A-I      intronic chr22:30009304(+) A-I      intronic chr22:30007396(+) A-I      intronic chr22:30007369(+) A-I      intronic chr22:30007239(+) A-I      intronic chr22:30006224(+) A-I      intronic chr22:30004482(+) A-I      intronic chr22:30004457(+) A-I      intronic chr22:30004456(+) A-I      intronic chr22:30004003(+) A-I      intronic chr22:30002937(+) A-I      intronic chr22:30002914(+) A-I      intronic chr22:30002875(+) A-I      intronic chr22:30002874(+) A-I      intronic chr22:30002872(+) A-I      intronic chr22:30002056(+) A-I      intronic chr22:30001534(+) A-I      intronic chr22:30076242(+) A-I      intronic chr22:30016518(+) A-I      intronic chr22:30016088(+) A-I      intronic chr22:30008391(+) A-I      intronic chr22:30002070(+) A-I      intronic chr22:30004150(+) A-I      intronic chr22:30001319(+) A-I      intronic chr22:30075837(+) A-I      intronic chr22:30002863(+) A-I      intronic chr22:30065399(+) A-I      intronic chr22:30008451(+) A-I      intronic chr22:30004041(+) A-I      intronic chr22:30010515(+) A-I      intronic chr22:30002869(+) A-I      intronic chr22:30009866(+) A-I      intronic chr22:30016817(+) A-I      intronic chr22:30012969(+) A-I      intronic chr22:30010678(+) A-I      intronic chr22:30016607(+) A-I      intronic chr22:30082373(+) A-I      intronic chr22:30062550(+) A-I      intronic chr22:30008426(+) A-I      intronic chr22:30075757(+) A-I      intronic chr22:30081236(+) A-I      intronic chr22:30004669(+) A-I      intronic chr22:30048476(+) A-I      intronic chr22:30006145(+) A-I      intronic chr22:30048394(+) A-I      intronic chr22:30008411(+) A-I      intronic chr22:30008830(+) A-I      intronic chr22:30004111(+) A-I      intronic chr22:30012522(+) A-I      intronic chr22:30001337(+) A-I      intronic chr22:30062549(+) A-I      intronic chr22:30044792(+) A-I      intronic chr22:30049271(+) A-I      intronic chr22:30044676(+) A-I      intronic chr22:30009354(+) A-I      intronic chr22:30092269(+) A-I      3'UTR chr22:30092899(+) A-I      3'UTR chr22:30092244(+) A-I      3'UTR chr22:30093068(+) A-I      3'UTR chr22:30092238(+) A-I      3'UTR chr22:30007364(+) A-I      intronic chr22:30008829(+) A-I      intronic chr22:30061699(+) A-I      intronic chr22:30045656(+) A-I      intronic chr22:30012584(+) A-I      intronic chr22:30081536(+) A-I      intronic chr22:30001399(+) A-I      intronic chr22:30004149(+) A-I      intronic chr22:30017509(+) A-I      intronic chr22:30007361(+) A-I      intronic chr22:30008588(+) A-I      intronic chr22:30001271(+) A-I      intronic chr22:30044699(+) A-I      intronic chr22:30049257(+) A-I      intronic chr22:30009849(+) A-I      intronic chr22:30081652(+) A-I      intronic chr22:30002913(+) A-I      intronic chr22:30081509(+) A-I      intronic chr22:30077090(+) A-I      intronic chr22:30009922(+) A-I      intronic chr22:30075600(+) A-I      intronic chr22:30006101(+) A-I      intronic chr22:30044683(+) A-I      intronic chr22:30006228(+) A-I      intronic chr22:30082508(+) A-I      intronic chr22:30007310(+) A-I      intronic chr22:30008437(+) A-I      intronic chr22:30004082(+) A-I      intronic chr22:30048393(+) A-I      intronic chr22:30013018(+) A-I      intronic chr22:30001343(+) A-I      intronic chr22:30007269(+) A-I      intronic chr22:30004090(+) A-I      intronic chr22:30004074(+) A-I      intronic chr22:30001254(+) A-I      intronic chr22:30046789(+) A-I      intronic chr22:30081171(+) A-I      intronic chr22:30062527(+) A-I      intronic chr22:30049226(+) A-I      intronic chr22:30075584(+) A-I      intronic chr22:30081197(+) A-I      intronic chr22:30008534(+) A-I      intronic chr22:30007405(+) A-I      intronic chr22:30011052(+) A-I      intronic chr22:30004083(+) A-I      intronic chr22:30008412(+) A-I      intronic chr22:30081371(+) A-I      intronic chr22:30012517(+) A-I      intronic chr22:30012479(+) A-I      intronic chr22:30011590(+) A-I      intronic chr22:30001356(+) A-I      intronic chr22:30075653(+) A-I      intronic chr22:30002968(+) A-I      intronic chr22:30081674(+) A-I      intronic chr22:30076780(+) A-I      intronic chr22:30045490(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NF2	chr22:30004074(+) A-I intron -    15342557 chr22:30004082(+) A-I intron -    15342557 chr22:30004083(+) A-I intron -    15342557 chr22:30004090(+) A-I intron -    15342557 chr22:30004111(+) A-I intron -    15342557 chr22:30004149(+) A-I intron -    15342557 chr22:30004150(+) A-I intron -    15342557 chr22:30093544(+) A-I intron -    21960545 chr22:30001254(+) A-G intron -    22484847 chr22:30001271(+) A-G intron -    22484847 chr22:30002968(+) A-G intron -    22484847 chr22:30007364(+) A-G intron -    22484847 chr22:30010515(+) A-G intron -    22484847 chr22:30044683(+) A-G intron -    22484847 chr22:30044699(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NF2	chr22:30067911-30067912(+) m1A CDS//intron       26863196 chr22:30069272-30069273(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30069322-30069323(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30070853-30070854(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960 chr22:30074191-30074192(+) m6A CDS//intron       24209618//24981863 chr22:30077475-30077476(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077482-30077483(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077502-30077503(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077507-30077508(+) Am CDS//intron       - chr22:30077518-30077519(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30077546-30077547(+) m6A CDS//intron       24284625//24981863//27773535 chr22:30079028-30079029(+) m6A CDS//intron       24284625 chr22:30090813-30090814(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30090838-30090839(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30090850-30090851(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30090911-30090912(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30090964-30090965(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091158-30091159(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091214-30091215(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091238-30091239(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr22:30091425-30091426(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr22:30091534-30091535(+) m6A 3'UTR       24284625 chr22:30091719-30091720(+) m6A 3'UTR       24284625 chr22:30092198-30092199(+) m6A 3'UTR       24209618 chr22:30093362-30093363(+) m6A 3'UTR       24284625 chr22:30093370-30093371(+) m6A 3'UTR       24284625 chr22:30093524-30093525(+) m6A 3'UTR       - chr22:30093776-30093777(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-363-3p	Cytoplasm Neural progenitor cells     21363885 Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293)     22984580
	NF2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-363-3p	Tetrangulol 99188 Drug sensitive Azacitidine 9444 Drug resistant Coptisine chloride 72321 Drug sensitive Tolonium chloride 7083 Drug sensitive Azure B 68275 Drug sensitive 3-Hydroxy-N-1-naphthyl-2-naphthamide 67241 Drug sensitive Psammaplin A 6400741 Drug sensitive Methylene blue 6099 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Adenosine, 2-bromo-2'-deoxy- 55914 Drug sensitive 11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant (E)-1-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)prop-2-en-1-one 5469981 Drug resistant Bleomycin 5460769 Drug resistant Indanthren Corinth RK 5351878 Drug sensitive N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug resistant 5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug resistant Vorinostat 5311 Drug sensitive Elsinochrome C 495866 Drug sensitive 6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive Itraconazole, 99% 45039617 Drug resistant 9-beta-D-Xylofuranosyladenine 447916 Drug resistant Latrunculin a 445420 Drug resistant 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant 2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Bleomycin A5, sulfate 422920 Drug resistant N-Benzyl-5-chloropyrazine-2-carboxamide 406085 Drug sensitive Menadione 4055 Drug sensitive Rogiolol 402519 Drug sensitive 1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive Kuanoniamine A 390989 Drug sensitive Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive 19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive 7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive 5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Miltefosine 3599 Drug resistant 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive 6,7-Diacetoxyisoflavan 353129 Drug sensitive Helenin 327378 Drug sensitive Dasatinib 3062316 Drug resistant Phenanthrene-9,10-diimine 2981 Drug sensitive (15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive Estramustine 259331 Drug sensitive Isoindolo[2,1-a]quinoxaline-6(5H)-one 24205090 Drug resistant (-)-Leucascandrolide A 24203380 Drug resistant 1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive 1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug resistant 4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug resistant 3,6-Diamino-10-methylacridinium chloride hydrochloride 15558347 Drug resistant Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive 6-Aryl-pyrazolo[3,4-b]pyridine analogue 13 135435011 Drug resistant Discorhabdin B 135409044 Drug sensitive Purpurogallin 135403797 Drug sensitive Mercury, (4-aminophenyl)(6-thioguanosinato-N7,S6)- 135403617 Drug sensitive Allopurinol 135401907 Drug resistant Halomon 132430 Drug resistant 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-Deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside 132274946 Drug resistant Dibutyltin dichloride 12688 Drug sensitive 15-Deacetylsergeolide 125729 Drug sensitive Benzoanthracenone 12300036 Drug resistant Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Cyanoaminopyranopyridine derivatives 11494577 Drug resistant Chimaphilin 101211 Drug sensitive antineoplastic-d655481 - Drug resistant bengamide g - Drug resistant Carboqone; Carbazilquinone - Drug resistant michicarcin - Drug resistant protein: pa30-14 - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant tp4ek-k6 - Drug resistant 1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 2-(n,n-diethyl)acetyl-1,2-dihydroellipticine - Drug sensitive 3,3'-diamino-4,4'-bis(dimethylamino)benzophenone - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 6-(4-ethylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug sensitive 6h-purine-6-thione, 1,7-dihydro-, mercury complex (9ci) - Drug sensitive 7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive 9-cis-retinol,palmitic acid ester - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, diacetate - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive dichloro(dodeca-2,6,10-triene-1,12-diyl)- ruthenium - Drug sensitive gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive 2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive 3-farnesylthiopropionamide - Drug sensitive antineoplastic-d183258 - Drug sensitive chlorambucil-spermidine - Drug sensitive crambescidin 800 trihydrochloride - Drug sensitive hymenialdisine - Drug sensitive potassium arsenite - Drug sensitive rh(iii)-amodiaquine - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-363-3p	Formaldehyde 712 Drug interaction    RC00004045 Alocrest 60780 Drug interaction    RC00004053 Eloxatine 5310940 Drug interaction    RC00004055 Paroxetine 43815 Drug interaction    RC00004052 Idarubicin 42890 Drug interaction    RC00004057 Paclitaxel 36314 Drug interaction    RC00004051 5-Fluorouracil 3385 Drug interaction    RC00004049 Emodin 3220 Drug interaction    RC00004048 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004047 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004056 Bicalutamide 2375 Drug interaction    RC00004046 Arsenic trioxide 14888 Drug interaction    RC00004050 Docetaxel 148124 Drug interaction    RC00004054 Chemotherapy - Drug interaction    RC00008855

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-363-3p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-363-3p
Interactor2: NF2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.