Basic Information:

  VIRBase ID:  

HHID00056492

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-362-5p:  MIMAT0000705          DAZAP2:  NM_014764     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-362-5p	DAZAP2
miRBase Accession/Entrez ID	MIMAT0000705	9802
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRTB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-362-5p	rs374141752 chrX:50008989    A/T rs781842604 chrX:50008976    G/A rs1432884260 chrX:50008971    C/G rs782748998 chrX:50008975    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DAZAP2	chr12:51635585(+) A-I      intronic chr12:51635472(+) A-I      intronic chr12:51635574(+) A-I      intronic chr12:51635594(+) A-I      intronic chr12:51635609(+) A-I      intronic chr12:51635625(+) A-I      intronic chr12:51638085(+) A-I      intronic chr12:51638161(+) A-I      intronic chr12:51635518(+) A-I      intronic chr12:51635521(+) A-I      intronic chr12:51638006(+) A-I      intronic chr12:51633566(+) A-I      intronic chr12:51638098(+) A-I      intronic chr12:51635519(+) A-I      intronic chr12:51638164(+) A-I      intronic chr12:51638244(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DAZAP2	chr12:51635518(+) A-G intron -    22484847 chr12:51635519(+) A-G intron -    22484847 chr12:51635629(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DAZAP2	chr12:51632599-51632600(+) m6A 5'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr12:51632628-51632629(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22608085 chr12:51632669-51632670(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632678-51632679(+) m6A 5'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632695-51632696(+) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51632710-51632711(+) m6A exon//intron       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:51634188-51634189(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr12:51634269-51634270(+) m6A exon//intron       24284625//24981863//22575960 chr12:51637021-51637022(+) m6A 3'UTR//exon//intron       26404942 chr12:51637037-51637038(+) m6A 3'UTR//exon//intron       26404942 chr12:51637054-51637055(+) m6A 3'UTR//exon//intron       26404942 chr12:51637066-51637067(+) m6A 3'UTR//exon//intron       26404942 chr12:51639887-51639888(+) m6A CDS//intron       27773535 chr12:51640038-51640039(+) m6A 3'UTR//intron       27773535 chr12:51640110-51640111(+) m6A 3'UTR//intron       24209618 chr12:51640189-51640190(+) m6A 3'UTR//intron       24209618 chr12:51664532-51664533(+) m6A 3'UTR       24209618//25456834//22608085 chr12:51664659-51664660(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:51664672-51664673(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:51664978-51664979(+) m6A 3'UTR       24981863 chr12:51665083-51665084(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-362-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DAZAP2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-362-5p	Gemcitabine 60750 Drug interaction    RC00004038 Sunitinib 5329102 Drug interaction    RC00004040 Eloxatine 5310940 Drug interaction    RC00004039 Imatinib 5291 Drug interaction    RC00004036 5-Fluorouracil 3385 Drug interaction    RC00004035 Doxorubicin 31703 Drug interaction    RC00004037 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004034

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-362-5p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-362-5p
Interactor2: DAZAP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.