Detail Information

Basic Information:


  VIRBase ID:  

HHID00056207

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30e-5p:           JAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30e-5p JAK1
miRBase
Accession/Entrez ID		 MIMAT0000692 3716
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AIIDE//JAK1A//JAK1B//JTK3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30e-5p
rs1470046939 chr1:40754386    C/T
rs765470560 chr1:40754383    T/C
rs768482782 chr1:40754389    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR JAK1
chr1:65382439(-) A-I      intronic
chr1:65382457(-) A-I      intronic
chr1:65382476(-) A-I      intronic
chr1:65382275(-) A-I      intronic
chr1:65380495(-) A-I      intronic
chr1:65380366(-) A-I      intronic
chr1:65417546(-) A-I      intronic
chr1:65419595(-) A-I      intronic
chr1:65425889(-) A-I      intronic
chr1:65425692(-) A-I      intronic
chr1:65425688(-) A-I      intronic
chr1:65419481(-) A-I      intronic
chr1:65406164(-) A-I      intronic
chr1:65406160(-) A-I      intronic
chr1:65406148(-) A-I      intronic
chr1:65398013(-) A-I      intronic
chr1:65411609(-) A-I      intronic
chr1:65411677(-) A-I      intronic
chr1:65417506(-) A-I      intronic
chr1:65417536(-) A-I      intronic
chr1:65417537(-) A-I      intronic
chr1:65409716(-) A-I      intronic
chr1:65382522(-) A-I      intronic
chr1:65406223(-) A-I      intronic
chr1:65397930(-) A-I      intronic
chr1:65397913(-) A-I      intronic
chr1:65397893(-) A-I      intronic
chr1:65406203(-) A-I      intronic
chr1:65406193(-) A-I      intronic
chr1:65382518(-) A-I      intronic
chr1:65419630(-) A-I      intronic
chr1:65406188(-) A-I      intronic
chr1:65419631(-) A-I      intronic
chr1:65423259(-) A-I      intronic
chr1:65409741(-) A-I      intronic
chr1:65409866(-) A-I      intronic
chr1:65406739(-) A-I      intronic
chr1:65315058(-) A-I      intronic
chr1:65417596(-) A-I      intronic
chr1:65406804(-) A-I      intronic
chr1:65382426(-) A-I      intronic
chr1:65382473(-) A-I      intronic
chr1:65406725(-) A-I      intronic
chr1:65406735(-) A-I      intronic
chr1:65406097(-) A-I      intronic
chr1:65398060(-) A-I      intronic
chr1:65419467(-) A-I      intronic
chr1:65401230(-) A-I      intronic
chr1:65406613(-) A-I      intronic
chr1:65406128(-) A-I      intronic
chr1:65406588(-) A-I      intronic
chr1:65326387(-) A-I      intronic
chr1:65406242(-) A-I      intronic
chr1:65406110(-) A-I      intronic
chr1:65428741(-) A-I      intronic
chr1:65406631(-) A-I      intronic
chr1:65406127(-) A-I      intronic
chr1:65406096(-) A-I      intronic
chr1:65401202(-) A-I      intronic
chr1:65351414(-) A-I      intronic
chr1:65406682(-) A-I      intronic
chr1:65346554(-) A-I      intronic
chr1:65406685(-) A-I      intronic
chr1:65406676(-) A-I      intronic
chr1:65423505(-) A-I      intronic
chr1:65417728(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED JAK1
chr1:65346554(-) A-G intron -    22484847
chr1:65401230(-) A-G intron -    22484847
chr1:65406613(-) A-G intron -    22484847
chr1:65406631(-) A-G intron -    22484847
chr1:65406682(-) A-G intron -    22484847
chr1:65406685(-) A-G intron -    22484847
chr1:65406725(-) A-G intron -    22484847
chr1:65406735(-) A-G intron -    22484847
chr1:65411671(-) G-A intron -    22484847
chr1:65416064(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase JAK1
chr1:65299215-65299216(-) m6A 3'UTR       26404942
chr1:65299232-65299233(-) m6A 3'UTR       26404942
chr1:65299253-65299254(-) m6A 3'UTR       26404942
chr1:65299483-65299484(-) m6A 3'UTR       26404942//27773535
chr1:65299496-65299497(-) m6A 3'UTR       26404942//27773535
chr1:65299543-65299544(-) m6A 3'UTR       26404942//27773535
chr1:65299671-65299672(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299677-65299678(-) m6A 3'UTR       24284625//26404942//27773535
chr1:65299758-65299759(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65299795-65299796(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300062-65300063(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300122-65300123(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr1:65300278-65300279(-) m6A CDS       26404942
chr1:65300291-65300292(-) m6A CDS       26404942
chr1:65303629-65303630(-) m6A CDS       26404942
chr1:65305320-65305321(-) m6A CDS//exon       26404942
chr1:65305335-65305336(-) m6A CDS//exon       26404942
chr1:65305431-65305432(-) m6A CDS//exon       26404942
chr1:65306979-65306980(-) m6A CDS       26404942
chr1:65306996-65306997(-) m6A CDS       26404942
chr1:65307156-65307157(-) m6A CDS//exon       26404942//27773535
chr1:65307201-65307202(-) m6A CDS//exon       26404942//27773535
chr1:65309762-65309763(-) m6A CDS//exon       26404942//27773535
chr1:65313239-65313240(-) m6A CDS//exon       26404942
chr1:65313282-65313283(-) m6A CDS//exon       26404942//27773535
chr1:65313312-65313313(-) m6A CDS//exon       26404942//27773535
chr1:65313330-65313331(-) m6A CDS//exon       26404942//27773535
chr1:65321277-65321278(-) m6A CDS       22575960
chr1:65321301-65321302(-) m6A CDS       22575960
chr1:65321349-65321350(-) m6A CDS       22575960
chr1:65330554-65330555(-) m6A CDS       24981863
chr1:65330575-65330576(-) m6A CDS       24981863
chr1:65330598-65330599(-) m6A CDS       24981863//27371828
chr1:65330610-65330611(-) m6A CDS       24981863//27371828
chr1:65330625-65330626(-) m6A CDS       24981863//26404942//27371828
chr1:65332554-65332555(-) m6A CDS       24981863//26404942//27371828
chr1:65332676-65332677(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332701-65332702(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332712-65332713(-) m6A CDS       24981863//26404942//27371828//22608085
chr1:65332775-65332776(-) m6A CDS       26404942//22608085
chr1:65332840-65332841(-) m6A CDS       26404942
chr1:65332848-65332849(-) m6A CDS       26404942
chr1:65332868-65332869(-) m6A CDS       26404942
chr1:65334999-65335000(-) m6A CDS       26404942
chr1:65335010-65335011(-) m6A CDS       26404942
chr1:65335094-65335095(-) m6A CDS       26404942
chr1:65335108-65335109(-) m6A CDS       26404942
chr1:65335116-65335117(-) m6A CDS       26404942
chr1:65339180-65339181(-) m6A CDS       27773535
chr1:65341688-65341689(-) m6A exon//intron       27773535
chr1:65349033-65349034(-) m6A CDS       26404942
chr1:65349081-65349082(-) m6A CDS       26404942
chr1:65349091-65349092(-) m6A CDS       26404942
chr1:65349138-65349139(-) m6A CDS       26404942
chr1:65432181-65432182(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30e-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25349172
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular Vesicle Plasma     28588009
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
JAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30e-5p
Sensorad 99342 Drug sensitive
Piperidine, 2-methyl-6-undecyl- 99090 Drug sensitive
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive
1-(2-Thiazolylazo)-2-naphthol 93572 Drug sensitive
Dichlorodipropylstannane 93562 Drug sensitive
(3Z,8S,11Z,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone 92973777 Drug sensitive
Acridine Yellow G 8672 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
4,7-Diphenyl-1,10-phenanthroline 72812 Drug sensitive
4-(2-Naphthylamino)phenol 7141 Drug sensitive
Miconazole nitrate 68553 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug sensitive
Reactive Blue 2 656725 Drug sensitive
Ursolic acid 64945 Drug sensitive
Trihydroxygermaeranolide isobutyrate 6436277 Drug sensitive
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine;hydrochloride 57401575 Drug sensitive
Dezaguanine 55710 Drug sensitive
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug sensitive
5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug resistant
Incomptina B 54612584 Drug sensitive
Spermine hydrochloride 5351186 Drug sensitive
Benzamide riboside 458027 Drug sensitive
o6-Benzylguanine 4578 Drug sensitive
Physalolactone 433866 Drug sensitive
Diaziquone 42616 Drug sensitive
trans-Bis(acetato)amminepyridineplatinum(II) 405450 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
5-Chloro-2-(chloromethyl)-1,3-benzoxazole 401571 Drug sensitive
5,8-Quinolinedione, 2-methyl- 388305 Drug sensitive
Adaphostin 387042 Drug sensitive
N,N-Bis(2-chloropropyl)-N-methylammonium chloride 381678 Drug sensitive
Cycloalkannin 375418 Drug sensitive
O-Benzylfluorescein benzyl ester 371436 Drug sensitive
Discorhabdin C . TFA 362393 Drug sensitive
7,12-Epidioxybenz[a]anthracene, 7,12-dihydro-7-methyl- 362095 Drug sensitive
7alpha-Acetoxyroylenane 362048 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug resistant
Zonarol 332671 Drug sensitive
Hydroxypristimerin 320914 Drug sensitive
Butanedioic acid, 2-bromo-3-fluoro-, dimethyl ester 317895 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Benzofurazan, 4-[(3-methoxyphenyl)thio]-7-nitro-, 3-oxide 313591 Drug sensitive
[(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug sensitive
Etoprine 29142 Drug resistant
Quinoxaline, 6-chloro-2,3-bis(iodomethyl)- 286252 Drug sensitive
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
1-(3-Dimethylarsino-3-thio-2-methyl-1-oxopropyl)-L-proline 24203224 Drug sensitive
4-Amino-3-pentadecylphenol 219123 Drug sensitive
Pirarubicin hydrochloride 20846247 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Diphenyllead diacetate 16683784 Drug resistant
Ammonium tetrathiomolybdate 15251598 Drug resistant
(1R,16R)-6-Hydroxy-19-(1H-indol-3-ylmethyl)-7,9,16,17-tetramethyl-15-oxa-20-azatetracyclo[11.8.0.01,18.014,16]henicosa-3,7,11-triene-2,5,21-trione 146159025 Drug sensitive
(5S,10S,13R,14S)-3-[3,4-Dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,14-dihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde 146156945 Drug sensitive
Acid Alizarine Red B 135565636 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive
Eriochrome black t 135465089 Drug sensitive
Formycin b 135449281 Drug sensitive
Kinamycin C 135430800 Drug sensitive
2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug sensitive
Cytochalasin q 11970174 Drug sensitive
p-Toluquinone 11122 Drug sensitive
(1R,2E,6R,10E,11aS,13S,14aR)-1,13-dihydroxy-6-(2-methoxyethyl)-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug resistant
(1R,2E,6R,10E,11aS,13S,14aR)-6-(2-(benzyloxy)ethyl)-1,13-dihydroxy-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug resistant
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug resistant
2,3-dihydro-1,2-syn-2-[2'-aminopropylsulfenyl]-brefeldin a - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
N-(4-{2-[(1R,6R,11aS,13S,14aR)-1,13-dihydroxy-4-oxo-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-6-yl]ethyl}phenyl)acetamide - Drug resistant
N3-[1-(3-phenoxybenzyl)-1H-1,2,3-triazol-4-yl]methyl-2-(4-fluoroanilino)nicotinamide - Drug resistant
naphthalene-1,2-dione, 4-[(4-bromophenyl)amino]-, 1-oxime - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive
1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug sensitive
2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive
2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
2-acetyl-9-methoxy-1,2-dihydroellipticine - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive
2-propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl- (9ci) - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
cis-2-hydroxymethyl-4-(6'-azacytosin-1'-yl)-1,3-dioxolane - Drug sensitive
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug sensitive
dichloro(dodeca-2,6,10-triene-1,12-diyl)- ruthenium - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive
pyrido[3',4':4,5]thieno[2,3-g]isoquinoline, 6-methyl- - Drug sensitive
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug sensitive
uracil, 1,3-bis[1,2-bis(ethoxycarbonyl)ethenyl]- - Drug sensitive
2'-o-(all trans)-retinoyl-erythromicine a - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
7-propanoyltaxol - Drug sensitive
hymenialdisine - Drug sensitive
maleimide carbazole - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
o-linoleoyl-2-butoxy-1-desoamine - Drug sensitive
organosulfur compound - Drug sensitive
recombinant protein 1815 (plate 31 h4) - Drug sensitive
thiadiazines - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30e-5p
Oxaliplatine 6857599 Drug interaction    RC00004012
Gemcitabine 60750 Drug interaction    RC00004007
Progesterone 5994 Drug interaction    RC00004005
Sunitinib 5329102 Drug interaction    RC00004011
Eloxatine 5310940 Drug interaction    RC00004010
Imatinib 5291 Drug interaction    RC00004004
Bortezomib 387447 Drug interaction    RC00004009
5-Fluorouracil 3385 Drug interaction    RC00004003
Enoxacin 3229 Drug interaction    RC00004002
Doxorubicin 31703 Drug interaction    RC00004006
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004001
Verapamil 2520 Drug interaction    RC00004000
Docetaxel 148124 Drug interaction    RC00004008
Leucovorin 135403648 Drug interaction    RC00004013
platinum-based doublet chemotherapy - Drug interaction    RC00004014
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004015

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30e-5p
Interactor2: JAK1

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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