Detail Information

Basic Information:


  VIRBase ID:  

HHID00055572

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-34c-5p:           TRIM26:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-34c-5p TRIM26
miRBase
Accession/Entrez ID		 MIMAT0000686 7726
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AFP//RNF95//ZNF173

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-34c-5p
rs1164847227 chr11:111513469    A/G
rs1316355512 chr11:111513473    C/T
rs1446522077 chr11:111513468    G/A
rs375584546 chr11:111513467    T/C
rs752641880 chr11:111513464    A/G
rs777574451 chr11:111513470    T/C
rs1262116870 chr11:111513457    T/A
rs1429611756 chr11:111513452    G/A
rs756377381 chr11:111513456    G/A
rs778089989 chr11:111513458    G/T
rs930401173 chr11:111513453    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM26
chr6:30167686(-) A-I      intronic
chr6:30162508(-) A-I      intronic
chr6:30169441(-) A-I      intronic
chr6:30169497(-) A-I      intronic
chr6:30167618(-) A-I      intronic
chr6:30167546(-) A-I      intronic
chr6:30167510(-) A-I      intronic
chr6:30162669(-) A-I      intronic
chr6:30162647(-) A-I      intronic
chr6:30162550(-) A-I      intronic
chr6:30162532(-) A-I      intronic
chr6:30162520(-) A-I      intronic
chr6:30162497(-) A-I      intronic
chr6:30160435(-) A-I      intronic
chr6:30160428(-) A-I      intronic
chr6:30160412(-) A-I      intronic
chr6:30171331(-) A-I      intronic
chr6:30177580(-) A-I      intronic
chr6:30173427(-) A-I      intronic
chr6:30173394(-) A-I      intronic
chr6:30171461(-) A-I      intronic
chr6:30171445(-) A-I      intronic
chr6:30171444(-) A-I      intronic
chr6:30171398(-) A-I      intronic
chr6:30171397(-) A-I      intronic
chr6:30171389(-) A-I      intronic
chr6:30171388(-) A-I      intronic
chr6:30171387(-) A-I      intronic
chr6:30171357(-) A-I      intronic
chr6:30171318(-) A-I      intronic
chr6:30171282(-) A-I      intronic
chr6:30171220(-) A-I      intronic
chr6:30170897(-) A-I      intronic
chr6:30169586(-) A-I      intronic
chr6:30169568(-) A-I      intronic
chr6:30167983(-) A-I      intronic
chr6:30167868(-) A-I      intronic
chr6:30162484(-) A-I      intronic
chr6:30160431(-) A-I      intronic
chr6:30161129(-) A-I      intronic
chr6:30172815(-) A-I      intronic
chr6:30168009(-) A-I      intronic
chr6:30168053(-) A-I      intronic
chr6:30167609(-) A-I      intronic
chr6:30173380(-) A-I      intronic
chr6:30167959(-) A-I      intronic
chr6:30170949(-) A-I      intronic
chr6:30167680(-) A-I      intronic
chr6:30167865(-) A-I      intronic
chr6:30170893(-) A-I      intronic
chr6:30171095(-) A-I      intronic
chr6:30169509(-) A-I      intronic
chr6:30160330(-) A-I      intronic
chr6:30167876(-) A-I      intronic
chr6:30167447(-) A-I      intronic
chr6:30170928(-) A-I      intronic
chr6:30170989(-) A-I      intronic
chr6:30170888(-) A-I      intronic
chr6:30162671(-) A-I      intronic
chr6:30177834(-) A-I      intronic
chr6:30169581(-) A-I      intronic
chr6:30170918(-) A-I      intronic
chr6:30170980(-) A-I      intronic
chr6:30173398(-) A-I      intronic
chr6:30168018(-) A-I      intronic
chr6:30167804(-) A-I      intronic
chr6:30169499(-) A-I      intronic
chr6:30168045(-) A-I      intronic
chr6:30167552(-) A-I      intronic
chr6:30171330(-) A-I      intronic
chr6:30171467(-) A-I      intronic
chr6:30161044(-) A-I      intronic
chr6:30168012(-) A-I      intronic
chr6:30169379(-) A-I      intronic
chr6:30167947(-) A-I      intronic
chr6:30170856(-) A-I      intronic
chr6:30170988(-) A-I      intronic
chr6:30171602(-) A-I      intronic
chr6:30161183(-) A-I      intronic
chr6:30167669(-) A-I      intronic
chr6:30171097(-) A-I      intronic
chr6:30167813(-) A-I      intronic
chr6:30169433(-) A-I      intronic
chr6:30168002(-) A-I      intronic
chr6:30162492(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM26
chr6:30152244-30152245(-) m6A 3'UTR//exon       27773535
chr6:30152459-30152460(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085
chr6:30152614-30152615(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr6:30152701-30152702(-) m6A 3'UTR//exon       24284625//27773535
chr6:30152815-30152816(-) m6A 3'UTR//exon       24284625
chr6:30152836-30152837(-) m6A 3'UTR//exon       24284625
chr6:30152844-30152845(-) m6A 3'UTR//exon       24284625
chr6:30152874-30152875(-) m6A 3'UTR//exon       24284625
chr6:30153136-30153137(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr6:30153188-30153189(-) m6A 3'UTR//exon       24981863
chr6:30153192-30153193(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153252-30153253(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153291-30153292(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153302-30153303(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153419-30153420(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr6:30153543-30153544(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30153592-30153593(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153658-30153659(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153675-30153676(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153745-30153746(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153920-30153921(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153941-30153942(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153998-30153999(-) m1A CDS//exon       26863196//26863410
chr6:30154121-30154122(-) m1A CDS//exon       26863196//26863410
chr6:30154280-30154281(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30154319-30154320(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30154929-30154930(-) m6A intron       27773535
chr6:30154953-30154954(-) m6A intron       27773535
chr6:30154960-30154961(-) m6A intron       27773535
chr6:30155024-30155025(-) m6A intron       27773535
chr6:30156946-30156947(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr6:30156960-30156961(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr6:30157231-30157232(-) m6A CDS//exon       24284625//24209618//27773535//22575960
chr6:30157251-30157252(-) m6A CDS//exon       24284625
chr6:30157279-30157280(-) m6A CDS//exon       24284625
chr6:30157792-30157793(-) m6A CDS//exon       27371828//27773536
chr6:30157801-30157802(-) m6A CDS//exon       27371828//27773536
chr6:30157810-30157811(-) m6A CDS//exon       27371828//27773536
chr6:30157926-30157927(-) m6A exon//intron       27371828//27773536
chr6:30164334-30164335(-) m6A CDS       24284625//24209618//27773535//27371828//27773536
chr6:30164433-30164434(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30164445-30164446(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30164509-30164510(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166257-30166258(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166263-30166264(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166287-30166288(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166629-30166630(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30166650-30166651(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30166689-30166690(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:30166806-30166807(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:30166891-30166892(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr6:30166901-30166902(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr6:30166923-30166924(-) m1A 5'UTR//intron       26863196
chr6:30172447-30172448(-) m6A 5'UTR//exon//intron       24284625//24209618//27773535
chr6:30172493-30172494(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535
chr6:30181084-30181085(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr6:30181141-30181142(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr6:30181148-30181149(-) m6A 5'UTR       24284625//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-34c-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     24683445
Exosome Blood|Epithelial cells|Mast cells     -
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293)     22984580
TRIM26
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-34c-5p
Arjunolic acid 73641 Drug resistant
Morpholine-N-dithiocarbamate 72675 Drug resistant
Melicopidine 68060 Drug resistant
N-(4-Amino-4-deoxy-N10-methypteroyl)-L-homocysteic acid 6712549 Drug resistant
4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 66718 Drug sensitive
Baker's Antifol 64840 Drug resistant
Ferric-taxol 54612932 Drug resistant
Unii-kka9W8egk5 499991 Drug sensitive
H-Cys(mmt)-OH 420454 Drug resistant
Lomustine 3950 Drug resistant
2-((4-(((2,4-Diaminopteridin-6-yl)methyl)methylamino)phenyl)carbonylamino)-4-sulfobutanoic acid 393791 Drug resistant
2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug resistant
15-Oxozoapatlin 391317 Drug resistant
Acronycine, 2-nitro 342903 Drug sensitive
Trimetrexate glucuronic acid salt 336805 Drug resistant
Janus Red 3081985 Drug resistant
L-Cysteine, S-[bis(4-methylphenyl)phenylmethyl]- 275979 Drug resistant
Hookerianamide J 25016666 Drug resistant
4'-(1H-Benzimidazol-2-yl)1,1biphenyl-4-amine 24205338 Drug resistant
1,3-Diamino-5-methylphenazinium chloride 14132 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
7-benzyl-5,7-dihydro-4h-isoxazolo[5,4-e]isoindole - Drug resistant
acetic acid, thio-,s-[.alpha.-(nitromethyl)benzyl] ester - Drug resistant
benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug resistant
sp-adenosine-3',5'-cyclic phosphorothioate - Drug resistant
7-ethyl-9-methoxy-5-ethoxycamptothecin - Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
antineoplastic-625577 - Drug resistant
carzinostatin - Drug resistant
ERB-38 Immunotoxin - Drug resistant
his 47-methyl ct - Drug resistant
(3-(4-bromophenyl)-5-(1,3-diphenyl-1H-pyrazol-4-yl)-4,5-dihydropyrazol-1-yl)(4-methoxyphenyl)methanone - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-34c-5p
Curcumin 969516 Drug interaction    RC00003918
Alocrest 60780 Drug interaction    RC00003914
Gemcitabine 60750 Drug interaction    RC00003913
D-Glucose 5793 Drug interaction    RC00003908
Eloxatine 5310940 Drug interaction    RC00003919
Imatinib 5291 Drug interaction    RC00003907
Etoposide 36462 Drug interaction    RC00003912
Paclitaxel 36314 Drug interaction    RC00003911
Glyburide 3488 Drug interaction    RC00003906
Flutamide 3397 Drug interaction    RC00003905
Doxorubicin 31703 Drug interaction    RC00003910
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003904
Erlotinib 176870 Drug interaction    RC00003917
Arsenic trioxide 14888 Drug interaction    RC00003909
Methotrexate 126941 Drug interaction    RC00003916
Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00003921
CDF(analogues of curcumin) - Drug interaction    RC00003922
Chemotherapy - Drug interaction    RC00008853
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003920
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-34c-5p
Carboplatin 426756       28459431
Paclitaxel 36314       22370637
Paclitaxel 36314       23423488
Docetaxel 148124       28459431
(9S)-7-[(2R)-4-Amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 137704806       27097054
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-34c-5p
l-685,458       5479543
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-34c-5p
Interactor2: TRIM26

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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