Basic Information:

  VIRBase ID:  

HHID00054399

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-155-5p:  MIMAT0000646          PAPOLA:  NM_001363665     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-155-5p	PAPOLA
miRBase Accession/Entrez ID	MIMAT0000646	10914
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAP//PAP-alpha

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-155-5p	rs1211177960 chr21:25573994    C/T rs1487851625 chr21:25574003    G/A rs761506722 chr21:25573995    G/A rs761506722 chr21:25573995    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAPOLA	chr14:97028491(+) A-I      intronic chr14:97028503(+) A-I      intronic chr14:96995872(+) A-I      intronic chr14:96980717(+) A-I      intronic chr14:96992809(+) A-I      intronic chr14:96995902(+) A-I      intronic chr14:96988817(+) A-I      intronic chr14:96996793(+) A-I      intronic chr14:96991941(+) A-I      intronic chr14:96991967(+) A-I      intronic chr14:97028490(+) A-I      intronic chr14:96985229(+) A-I      intronic chr14:96972438(+) A-I      intronic chr14:96991010(+) A-I      intronic chr14:97019979(+) A-I      intronic chr14:96970875(+) A-I      intronic chr14:97000097(+) A-I      intronic chr14:97019600(+) A-I      intronic chr14:96996008(+) A-I      intronic chr14:97015792(+) A-I      intronic chr14:96975402(+) A-I      intronic chr14:96996911(+) A-I      intronic chr14:96996000(+) A-I      intronic chr14:97019697(+) A-I      intronic chr14:96970917(+) A-I      intronic chr14:97019727(+) A-I      intronic chr14:96995912(+) A-I      intronic chr14:96970784(+) A-I      intronic chr14:97019588(+) A-I      intronic chr14:96996759(+) A-I      intronic chr14:96996824(+) A-I      intronic chr14:96995980(+) A-I      intronic chr14:96990907(+) A-I      intronic chr14:96997419(+) A-I      intronic chr14:96972341(+) A-I      intronic chr14:97020058(+) A-I      intronic chr14:96985351(+) A-I      intronic chr14:96988036(+) A-I      intronic chr14:96988368(+) A-I      intronic chr14:96988860(+) A-I      intronic chr14:96988902(+) A-I      intronic chr14:96988942(+) A-I      intronic chr14:96990084(+) A-I      intronic chr14:96990090(+) A-I      intronic chr14:96990160(+) A-I      intronic chr14:96990201(+) A-I      intronic chr14:97019805(+) A-I      intronic chr14:96990212(+) A-I      intronic chr14:96990225(+) A-I      intronic chr14:96990880(+) A-I      intronic chr14:96990884(+) A-I      intronic chr14:96991984(+) A-I      intronic chr14:96994987(+) A-I      intronic chr14:96996836(+) A-I      intronic chr14:96995782(+) A-I      intronic chr14:96995804(+) A-I      intronic chr14:96990028(+) A-I      intronic chr14:96995805(+) A-I      intronic chr14:96995871(+) A-I      intronic chr14:96988084(+) A-I      intronic chr14:96985160(+) A-I      intronic chr14:96995896(+) A-I      intronic chr14:96995904(+) A-I      intronic chr14:96997395(+) A-I      intronic chr14:96995944(+) A-I      intronic chr14:96995965(+) A-I      intronic chr14:97019906(+) A-I      intronic chr14:96997245(+) A-I      intronic chr14:96987961(+) A-I      intronic chr14:96997456(+) A-I      intronic chr14:96988916(+) A-I      intronic chr14:96990224(+) A-I      intronic chr14:96996962(+) A-I      intronic chr14:96996823(+) A-I      intronic chr14:96995988(+) A-I      intronic chr14:96996046(+) A-I      intronic chr14:96997469(+) A-I      intronic chr14:96997480(+) A-I      intronic chr14:97019568(+) A-I      intronic chr14:96977716(+) A-I      intronic chr14:96997488(+) A-I      intronic chr14:97019696(+) A-I      intronic chr14:96997491(+) A-I      intronic chr14:96997515(+) A-I      intronic chr14:96995938(+) A-I      intronic chr14:96997524(+) A-I      intronic chr14:96997549(+) A-I      intronic chr14:96997711(+) A-I      intronic chr14:96997253(+) A-I      intronic chr14:96988050(+) A-I      intronic chr14:97019793(+) A-I      intronic chr14:96990970(+) A-I      intronic chr14:97019668(+) A-I      intronic chr14:96985139(+) A-I      intronic chr14:97019651(+) A-I      intronic chr14:96995916(+) A-I      intronic chr14:96997182(+) A-I      intronic chr14:96970918(+) A-I      intronic chr14:96997658(+) A-I      intronic chr14:96996009(+) A-I      intronic chr14:97016308(+) A-I      intronic chr14:96972380(+) A-I      intronic chr14:97019512(+) A-I      intronic chr14:96979561(+) A-I      intronic chr14:96991961(+) A-I      intronic chr14:96987957(+) A-I      intronic chr14:96972421(+) A-I      intronic chr14:97019601(+) A-I      intronic chr14:96972267(+) A-I      intronic chr14:96985339(+) A-I      intronic chr14:96997545(+) A-I      intronic chr14:96990027(+) A-I      intronic chr14:97019737(+) A-I      intronic chr14:96997694(+) A-I      intronic chr14:97019434(+) A-I      intronic chr14:96991968(+) A-I      intronic chr14:96996592(+) A-I      intronic chr14:96990070(+) A-I      intronic chr14:96995796(+) A-I      intronic chr14:96997326(+) A-I      intronic chr14:96997252(+) A-I      intronic chr14:97019813(+) A-I      intronic chr14:96996864(+) A-I      intronic chr14:96970958(+) A-I      intronic chr14:97023649(+) A-I      intronic chr14:96990071(+) A-I      intronic chr14:96996909(+) A-I      intronic chr14:96996854(+) A-I      intronic chr14:96995899(+) A-I      intronic chr14:97019654(+) A-I      intronic chr14:96985517(+) A-I      intronic chr14:96992787(+) A-I      intronic chr14:97019483(+) A-I      intronic chr14:96988197(+) A-I      intronic chr14:96988044(+) A-I      intronic chr14:97016364(+) A-I      intronic chr14:97019640(+) A-I      intronic chr14:96988956(+) A-I      intronic chr14:97019630(+) A-I      intronic chr14:97030563(+) A-I      intronic chr14:97019517(+) A-I      intronic chr14:96995952(+) A-I      intronic chr14:97019900(+) A-I      intronic chr14:96995857(+) A-I      intronic chr14:96995856(+) A-I      intronic chr14:97020083(+) A-I      intronic chr14:96997478(+) A-I      intronic chr14:96997390(+) A-I      intronic chr14:96985376(+) A-I      intronic chr14:97016288(+) A-I      intronic chr14:96985138(+) A-I      intronic chr14:97019594(+) A-I      intronic chr14:96997650(+) A-I      intronic chr14:97019950(+) A-I      intronic chr14:96997522(+) A-I      intronic chr14:97019903(+) A-I      intronic chr14:97019469(+) A-I      intronic chr14:96989016(+) A-I      intronic chr14:96996851(+) A-I      intronic chr14:96985162(+) A-I      intronic chr14:96995897(+) A-I      intronic chr14:97000021(+) A-I      intronic chr14:96995882(+) A-I      intronic chr14:96997468(+) A-I      intronic chr14:96970762(+) A-I      intronic chr14:96970963(+) A-I      intronic chr14:96997521(+) A-I      intronic chr14:97030643(+) A-I      intronic chr14:97016235(+) A-I      intronic chr14:96997308(+) A-I      intronic chr14:96988180(+) A-I      intronic chr14:97019509(+) A-I      intronic chr14:96978635(+) A-I      intronic chr14:97028497(+) A-I      intronic chr14:97019522(+) A-I      intronic chr14:96991946(+) A-I      intronic chr14:97019741(+) A-I      intronic chr14:96997600(+) A-I      intronic chr14:96997609(+) A-I      intronic chr14:96984275(+) A-I      intronic chr14:96972415(+) A-I      intronic chr14:96997191(+) A-I      intronic chr14:97016441(+) A-I      intronic chr14:96997251(+) A-I      intronic chr14:97019649(+) A-I      intronic chr14:96997599(+) A-I      intronic chr14:97019595(+) A-I      intronic chr14:97019750(+) A-I      intronic chr14:96982895(+) A-I      intronic chr14:96972358(+) A-I      intronic chr14:96968767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAPOLA	chr14:96968767(+) A-I exon 5'UTR    19478186 chr14:96970918(+) A-I intron -    15258596 chr14:96970958(+) A-I intron -    15258596 chr14:96970963(+) A-I intron -    15258596 chr14:97019524(+) A-I intron -    15258596 chr14:97019601(+) A-I intron -    15258596   //22327324 chr14:97019654(+) A-I intron -    15258596 chr14:97019668(+) A-I intron -    15258596 chr14:97019741(+) A-I intron -    21960545   //22327324 chr14:96992787(+) A-I intron -    21960545 chr14:96996773(+) A-I intron -    21960545 chr14:97030643(+) A-I intron -    21960545 chr14:97019601(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAPOLA	chr14:96967874-96967875(+) m6A exon       24981863//22608085 chr14:96968815-96968816(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//26404942//22575960//22608085 chr14:96969205-96969206(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr14:96970949-96970950(+) m6A exon//intron       - chr14:96971027-96971028(+) m6A exon//intron       26404942 chr14:96986419-96986420(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986482-96986483(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986505-96986506(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:97022188-97022189(+) m6A 3'UTR//CDS//exon       27773535 chr14:97022537-97022538(+) m6A 3'UTR//CDS       27773535 chr14:97022613-97022614(+) m6A 3'UTR//CDS       27773535 chr14:97022699-97022700(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022735-97022736(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022741-97022742(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97026828-97026829(+) m6A exon//intron       24981863//27773535 chr14:97026844-97026845(+) m6A exon//intron       24981863//27773535 chr14:97026981-97026982(+) m6A exon//intron       24284625 chr14:97026991-97026992(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027026-97027027(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027036-97027037(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97028798-97028799(+) m6A exon//intron       24284625 chr14:97029157-97029158(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22608085 chr14:97029173-97029174(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029194-97029195(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029203-97029204(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:97031294-97031295(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031307-97031308(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031368-97031369(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:97031389-97031390(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031409-97031410(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031472-97031473(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031477-97031478(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031637-97031638(+) m6A 3'UTR       24284625//24981863//22608085 chr14:97032261-97032262(+) m6A 3'UTR       27773535 chr14:97032297-97032298(+) m6A 3'UTR       27773535 chr14:97033298-97033299(+) m6A 3'UTR       27773535 chr14:97033397-97033398(+) m6A 3'UTR       27773535 chr14:97033423-97033424(+) m6A 3'UTR       27773535 chr14:97033439-97033440(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-155-5p	Exosome Cell lines (MCF10A|MCF-7|MDA-MB-231)     25446899 Exosome NBL cell lines (CHLA-255|IMR-32|SK-N-BE(2))     25972604 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome BC cell lines (HCC70|MCF-7|MDA-MB-231)     30728048 Exosome Serum     18589210 Exosome Plasma     19289371 Exosome Human embryonic kidney cell line (HEK-293)     20353945 Exosome Primary dendritic cells     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PAPOLA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-155-5p	Kahalalide F 9898671 Drug resistant Mitozolomide 71766 Drug sensitive Vedelianin 643539 Drug sensitive Irinotecan 60838 Drug sensitive 12,13-Dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione 5482344 Drug sensitive Tetrocarcin A, sodium salt 54724658 Drug sensitive Bleomycin 5460769 Drug sensitive Ternatin 5459184 Drug sensitive [2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug sensitive Proscillaridin 5284613 Drug sensitive Digitoxigenin 4369270 Drug sensitive 2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug sensitive 1-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosine 381525 Drug sensitive Antineoplastic-D648114 372647 Drug sensitive 5-Cinnamylidene-1,3-thiazolidine-2,4-dione 315044 Drug sensitive 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive 2-(4-Formyl(2-((methylsulfonyl)oxy)ethyl)anilino)ethyl methanesulfonate 230220 Drug sensitive Ellipticine analog 148569 Drug sensitive Saintopin 131350 Drug sensitive Pepleo 122804 Drug sensitive Celastrol 122724 Drug sensitive 6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug sensitive Clomesone 100651 Drug sensitive 1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug sensitive salicylaldehyde, 5-bromo- (8ci) - Drug sensitive Annamycin Liposomal - Drug sensitive antineoplastic-d665839 - Drug sensitive Camptothecin Derivative - Drug sensitive CI-921: amsacrine derivative - Drug sensitive Indenoisoquinoline derivative - Drug sensitive orlistat (usan) - Drug sensitive tunicamycin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-155-5p	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00003720 Curcumin 969516 Drug interaction    RC00003712 CID 790 790 Drug interaction    RC00003676 Ethanol 702 Drug interaction    RC00003675 Bisphenol A 6623 Drug interaction    RC00003696 Fludarabine 657237 Drug interaction    RC00003711 Cytarabine 6253 Drug interaction    RC00003695 Gemcitabine 60750 Drug interaction    RC00003701 Cholesterol 5997 Drug interaction    RC00003694 Progesterone 5994 Drug interaction    RC00003693 Vincristine 5978 Drug interaction    RC00003692 Prednisone 5865 Drug interaction    RC00003691 Epinephrine 5816 Drug interaction    RC00003690 Dexamethasone 5743 Drug interaction    RC00003689 Tetracycline 54675776 Drug interaction    RC00003723 Doxycycline 54671203 Drug interaction    RC00003722 Temozolomide 5394 Drug interaction    RC00003688 Sunitinib 5329102 Drug interaction    RC00003719 Vorinostat 5311 Drug interaction    RC00003687 Eloxatine 5310940 Drug interaction    RC00003718 Imatinib 5291 Drug interaction    RC00003686 Morphine 5288826 Drug interaction    RC00003717 Genistein 5280961 Drug interaction    RC00003716 Praziquantel 4891 Drug interaction    RC00003685 Decitabine 451668 Drug interaction    RC00003710 Cocaine 446220 Drug interaction    RC00003709 Trichostatin A 444732 Drug interaction    RC00003708 Cyclopamine 442972 Drug interaction    RC00003707 Metformin 4091 Drug interaction    RC00003684 Losartan 3961 Drug interaction    RC00003683 Hydroxychloroquine 3652 Drug interaction    RC00001355 Etoposide 36462 Drug interaction    RC00003700 Paclitaxel 36314 Drug interaction    RC00003699 5-Fluorouracil 3385 Drug interaction    RC00003682 Doxorubicin 31703 Drug interaction    RC00003698 Lithium 3028194 Drug interaction    RC00003715 Cyclophosphamide 2907 Drug interaction    RC00003681 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003680 Tamoxifen 2733526 Drug interaction    RC00003714 Thioguanine 2723601 Drug interaction    RC00003713 Verapamil 2520 Drug interaction    RC00003679 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003721 Acetaminophen 1983 Drug interaction    RC00003678 Erlotinib 176870 Drug interaction    RC00003706 Arsenic trioxide 14888 Drug interaction    RC00003697 Docetaxel 148124 Drug interaction    RC00003705 Gefitinib 123631 Drug interaction    RC00003704 Ginsenoside Rh2 119307 Drug interaction    RC00003703 Uric acid 1175 Drug interaction    RC00001352 Thiamine 1130 Drug interaction    RC00003677 Fulvestrant 104741 Drug interaction    RC00003702 Natalizumab - Drug interaction    RC00003725 Rituximab - Drug interaction    RC00003726 Sargramostim - Drug interaction    RC00003727 Aidi injection - Drug interaction    RC00003728 Glucocorticoid - Drug interaction    RC00003729 Medpor - Drug interaction    RC00003730 Aldesleukin - Drug interaction    RC00003724

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-155-5p	Cisplatin 5702198       30980798 Paclitaxel 36314       26323677 Paclitaxel 36314       30365045 Paclitaxel 36314       30980798 Doxorubicin 31703       30980798 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-155-5p
Interactor2: PAPOLA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.