Basic Information:

  VIRBase ID:  

HHID00054133

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-3p:  MIMAT0000617          MALT1:  NM_173844     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200c-3p	MALT1
miRBase Accession/Entrez ID	MIMAT0000617	10892
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD12//MLT//MLT1//PCASP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200c-3p	rs1400433260 chr12:6963758    T/C rs1400433260 chr12:6963758    T/G rs1466815657 chr12:6963753    G/A rs1555150271 chr12:6963750    C/T rs782249241 chr12:6963751    C/T rs904135271 chr12:6963752    G/A rs904135271 chr12:6963752    G/C rs1555150270 chr12:6963746    A/AC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MALT1	chr18:56398323(+) A-I      intronic chr18:56398313(+) A-I      intronic chr18:56418390(+) A-I      3'UTR chr18:56419846(+) A-I      3'UTR chr18:56398310(+) A-I      intronic chr18:56403338(+) A-I      intronic chr18:56400236(+) A-I      intronic chr18:56394639(+) A-I      intronic chr18:56356223(+) A-I      intronic chr18:56356222(+) A-I      intronic chr18:56356208(+) A-I      intronic chr18:56356169(+) A-I      intronic chr18:56356206(+) A-I      intronic chr18:56356183(+) A-I      intronic chr18:56373623(+) A-I      intronic chr18:56419977(+) A-I      3'UTR chr18:56372556(+) A-I      intronic chr18:56386971(+) A-I      intronic chr18:56398365(+) A-I      intronic chr18:56398341(+) A-I      intronic chr18:56398372(+) A-I      intronic chr18:56398371(+) A-I      intronic chr18:56398368(+) A-I      intronic chr18:56370335(+) A-I      intronic chr18:56370341(+) A-I      intronic chr18:56368124(+) A-I      intronic chr18:56340780(+) A-I      intronic chr18:56360517(+) A-I      intronic chr18:56347994(+) A-I      intronic chr18:56347978(+) A-I      intronic chr18:56347971(+) A-I      intronic chr18:56347216(+) A-I      intronic chr18:56340873(+) A-I      intronic chr18:56347183(+) A-I      intronic chr18:56346909(+) A-I      intronic chr18:56346865(+) A-I      intronic chr18:56346805(+) A-I      intronic chr18:56405091(+) A-I      intronic chr18:56405058(+) A-I      intronic chr18:56405037(+) A-I      intronic chr18:56404908(+) A-I      intronic chr18:56404865(+) A-I      intronic chr18:56342718(+) A-I      intronic chr18:56342716(+) A-I      intronic chr18:56404505(+) A-I      intronic chr18:56404504(+) A-I      intronic chr18:56404479(+) A-I      intronic chr18:56400309(+) A-I      intronic chr18:56400308(+) A-I      intronic chr18:56394827(+) A-I      intronic chr18:56393288(+) A-I      intronic chr18:56392529(+) A-I      intronic chr18:56371882(+) A-I      intronic chr18:56371864(+) A-I      intronic chr18:56371815(+) A-I      intronic chr18:56342710(+) A-I      intronic chr18:56371806(+) A-I      intronic chr18:56371789(+) A-I      intronic chr18:56371788(+) A-I      intronic chr18:56371710(+) A-I      intronic chr18:56370538(+) A-I      intronic chr18:56370478(+) A-I      intronic chr18:56370427(+) A-I      intronic chr18:56368225(+) A-I      intronic chr18:56370411(+) A-I      intronic chr18:56404563(+) A-I      intronic chr18:56420032(+) A-I      3'UTR chr18:56420674(+) A-I      3'UTR chr18:56419893(+) A-I      3'UTR chr18:56418459(+) A-I      3'UTR chr18:56420014(+) A-I      3'UTR chr18:56418514(+) A-I      3'UTR chr18:56420673(+) A-I      3'UTR chr18:56419782(+) A-I      3'UTR chr18:56419801(+) A-I      3'UTR chr18:56418500(+) A-I      3'UTR chr18:56420625(+) A-I      3'UTR chr18:56420573(+) A-I      3'UTR chr18:56419815(+) A-I      3'UTR chr18:56419880(+) A-I      3'UTR chr18:56420562(+) A-I      3'UTR chr18:56419747(+) A-I      3'UTR chr18:56420033(+) A-I      3'UTR chr18:56346946(+) A-I      intronic chr18:56393146(+) A-I      intronic chr18:56342700(+) A-I      intronic chr18:56404564(+) A-I      intronic chr18:56369495(+) A-I      intronic chr18:56413293(+) A-I      intronic chr18:56405076(+) A-I      intronic chr18:56404670(+) A-I      intronic chr18:56356125(+) A-I      intronic chr18:56355691(+) A-I      intronic chr18:56393190(+) A-I      intronic chr18:56368098(+) A-I      intronic chr18:56356174(+) A-I      intronic chr18:56369359(+) A-I      intronic chr18:56404980(+) A-I      intronic chr18:56369382(+) A-I      intronic chr18:56370510(+) A-I      intronic chr18:56403329(+) A-I      intronic chr18:56351339(+) A-I      intronic chr18:56400323(+) A-I      intronic chr18:56369591(+) A-I      intronic chr18:56371825(+) A-I      intronic chr18:56346929(+) A-I      intronic chr18:56371828(+) A-I      intronic chr18:56404521(+) A-I      intronic chr18:56404944(+) A-I      intronic chr18:56404914(+) A-I      intronic chr18:56370413(+) A-I      intronic chr18:56404457(+) A-I      intronic chr18:56400243(+) A-I      intronic chr18:56371782(+) A-I      intronic chr18:56405089(+) A-I      intronic chr18:56373347(+) A-I      intronic chr18:56370468(+) A-I      intronic chr18:56371873(+) A-I      intronic chr18:56404367(+) A-I      intronic chr18:56351348(+) A-I      intronic chr18:56404876(+) A-I      intronic chr18:56420591(+) A-I      3'UTR chr18:56369536(+) A-I      intronic chr18:56420660(+) A-I      3'UTR chr18:56419797(+) A-I      3'UTR chr18:56418542(+) A-I      3'UTR chr18:56419934(+) A-I      3'UTR chr18:56403242(+) A-I      intronic chr18:56418566(+) A-I      3'UTR chr18:56419764(+) A-I      3'UTR chr18:56419755(+) A-I      3'UTR chr18:56420470(+) A-I      3'UTR chr18:56418643(+) A-I      3'UTR chr18:56420020(+) A-I      3'UTR chr18:56405050(+) A-I      intronic chr18:56369509(+) A-I      intronic chr18:56420701(+) A-I      3'UTR chr18:56419756(+) A-I      3'UTR chr18:56420636(+) A-I      3'UTR chr18:56418415(+) A-I      3'UTR chr18:56419825(+) A-I      3'UTR chr18:56419452(+) A-I      3'UTR chr18:56420715(+) A-I      3'UTR chr18:56419788(+) A-I      3'UTR chr18:56405004(+) A-I      intronic chr18:56419911(+) A-I      3'UTR chr18:56420488(+) A-I      3'UTR chr18:56420713(+) A-I      3'UTR chr18:56403257(+) A-I      intronic chr18:56419885(+) A-I      3'UTR chr18:56418570(+) A-I      3'UTR chr18:56418464(+) A-I      3'UTR chr18:56420565(+) A-I      3'UTR chr18:56368277(+) A-I      intronic chr18:56371750(+) A-I      intronic chr18:56420619(+) A-I      3'UTR chr18:56404956(+) A-I      intronic chr18:56404612(+) A-I      intronic chr18:56419869(+) A-I      3'UTR chr18:56420567(+) A-I      3'UTR chr18:56420505(+) A-I      3'UTR chr18:56418493(+) A-I      3'UTR chr18:56419761(+) A-I      3'UTR chr18:56420555(+) A-I      3'UTR chr18:56371956(+) A-I      intronic chr18:56420526(+) A-I      3'UTR chr18:56418583(+) A-I      3'UTR chr18:56404954(+) A-I      intronic chr18:56419928(+) A-I      3'UTR chr18:56420553(+) A-I      3'UTR chr18:56419971(+) A-I      3'UTR chr18:56420525(+) A-I      3'UTR chr18:56420458(+) A-I      3'UTR chr18:56420506(+) A-I      3'UTR chr18:56420659(+) A-I      3'UTR chr18:56418445(+) A-I      3'UTR chr18:56418561(+) A-I      3'UTR chr18:56400269(+) A-I      intronic chr18:56419783(+) A-I      3'UTR chr18:56418424(+) A-I      3'UTR chr18:56420606(+) A-I      3'UTR chr18:56420700(+) A-I      3'UTR chr18:56418642(+) A-I      3'UTR chr18:56419465(+) A-I      3'UTR chr18:56418450(+) A-I      3'UTR chr18:56377778(+) A-I      intronic chr18:56420019(+) A-I      3'UTR chr18:56370329(+) A-I      intronic chr18:56418449(+) A-I      3'UTR chr18:56369426(+) A-I      intronic chr18:56419992(+) A-I      3'UTR chr18:56368164(+) A-I      intronic chr18:56419935(+) A-I      3'UTR chr18:56418517(+) A-I      3'UTR chr18:56419834(+) A-I      3'UTR chr18:56419886(+) A-I      3'UTR chr18:56419451(+) A-I      3'UTR chr18:56420616(+) A-I      3'UTR chr18:56356237(+) A-I      intronic chr18:56373237(+) A-I      intronic chr18:56420624(+) A-I      3'UTR chr18:56403300(+) A-I      intronic chr18:56371819(+) A-I      intronic chr18:56347234(+) A-I      intronic chr18:56404371(+) A-I      intronic chr18:56400196(+) A-I      intronic chr18:56400343(+) A-I      intronic chr18:56405024(+) A-I      intronic chr18:56353542(+) A-I      intronic chr18:56370438(+) A-I      intronic chr18:56371818(+) A-I      intronic chr18:56404941(+) A-I      intronic chr18:56404571(+) A-I      intronic chr18:56404555(+) A-I      intronic chr18:56355664(+) A-I      intronic chr18:56369535(+) A-I      intronic chr18:56400260(+) A-I      intronic chr18:56371854(+) A-I      intronic chr18:56400229(+) A-I      intronic chr18:56370495(+) A-I      intronic chr18:56393128(+) A-I      intronic chr18:56370514(+) A-I      intronic chr18:56404317(+) A-I      intronic chr18:56371720(+) A-I      intronic chr18:56371938(+) A-I      intronic chr18:56368117(+) A-I      intronic chr18:56368039(+) A-I      intronic chr18:56394782(+) A-I      intronic chr18:56396546(+) A-I      intronic chr18:56404526(+) A-I      intronic chr18:56370332(+) A-I      intronic chr18:56368123(+) A-I      intronic chr18:56405015(+) A-I      intronic chr18:56369603(+) A-I      intronic chr18:56404683(+) A-I      intronic chr18:56404863(+) A-I      intronic chr18:56404587(+) A-I      intronic chr18:56405049(+) A-I      intronic chr18:56368211(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MALT1	chr18:56370329(+) A-I intron -    22327324 chr18:56386252(+) A-I intron -    22327324 chr18:56404434(+) A-I intron -    22327324 chr18:56404571(+) A-I intron -    22327324 chr18:56386252(+) A-G intron -    22484847 chr18:56369328(+) A-G intron -    22484847 chr18:56369335(+) A-G intron -    22484847 chr18:56369495(+) A-G intron -    22484847 chr18:56369536(+) A-G intron -    22484847 chr18:56370329(+) A-G intron -    22484847 chr18:56370438(+) A-G intron -    22484847 chr18:56370469(+) A-G intron -    22484847 chr18:56370503(+) C-T intron -    22484847 chr18:56371750(+) A-G intron -    22484847 chr18:56371801(+) A-G intron -    22484847 chr18:56403300(+) A-G intron -    22484847 chr18:56403304(+) A-G intron -    22484847 chr18:56403318(+) A-G intron -    22484847 chr18:56404434(+) A-G intron -    22484847 chr18:56404457(+) A-G intron -    22484847 chr18:56404571(+) A-G intron -    22484847 chr18:56404587(+) A-G intron -    22484847 chr18:56404670(+) A-G intron -    22484847 chr18:56404863(+) A-G intron -    22484847 chr18:56404876(+) A-G intron -    22484847 chr18:56404914(+) A-G intron -    22484847 chr18:56405004(+) A-G intron -    22484847 chr18:56405024(+) A-G intron -    22484847 chr18:56405049(+) A-G intron -    22484847 chr18:56405077(+) A-G intron -    22484847 chr18:56386976(+) A-G intron -    22484847 chr18:56386985(+) A-G intron -    22484847 chr18:56387006(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MALT1	chr18:56338698-56338699(+) m6A 5'UTR       24981863 chr18:56338891-56338892(+) m6A CDS       24209618 chr18:56400765-56400766(+) m6A CDS//exon       22575960 chr18:56400770-56400771(+) m6A CDS//exon       22575960 chr18:56414638-56414639(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr18:56414700-56414701(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr18:56414725-56414726(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:56414745-56414746(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414771-56414772(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414783-56414784(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414862-56414863(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:56414942-56414943(+) m6A CDS//exon       24284625//24981863//26404942//22575960//22608085 chr18:56415017-56415018(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr18:56415144-56415145(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr18:56415206-56415207(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415214-56415215(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415250-56415251(+) m6A 3'UTR//exon       24981863//22608085 chr18:56416178-56416179(+) m6A 3'UTR       24981863 chr18:56416183-56416184(+) m6A 3'UTR       24981863 chr18:56416196-56416197(+) m6A 3'UTR       24981863 chr18:56416226-56416227(+) m6A 3'UTR       24981863 chr18:56417096-56417097(+) m6A 3'UTR       24981863 chr18:56417137-56417138(+) m6A 3'UTR       24981863 chr18:56417286-56417287(+) m6A 3'UTR       27773535 chr18:56417630-56417631(+) m6A 3'UTR       - chr18:56417660-56417661(+) m6A 3'UTR       - chr18:56417678-56417679(+) m6A 3'UTR       - chr18:56417691-56417692(+) m6A 3'UTR       - chr18:56417743-56417744(+) m6A 3'UTR       - chr18:56417764-56417765(+) m6A 3'UTR       - chr18:56417786-56417787(+) m6A 3'UTR       - chr18:56417791-56417792(+) m6A 3'UTR       - chr18:56417805-56417806(+) m6A 3'UTR       - chr18:56417894-56417895(+) m6A 3'UTR       - chr18:56417978-56417979(+) m6A 3'UTR       - chr18:56417998-56417999(+) m6A 3'UTR       - chr18:56418012-56418013(+) m6A 3'UTR       - chr18:56418058-56418059(+) m6A 3'UTR       - chr18:56418091-56418092(+) m6A 3'UTR       - chr18:56418107-56418108(+) m6A 3'UTR       - chr18:56418140-56418141(+) m6A 3'UTR       - chr18:56418214-56418215(+) m6A 3'UTR       - chr18:56418222-56418223(+) m6A 3'UTR       - chr18:56418271-56418272(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200c-3p	Exosome Urine     26576778 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Ascites fluid|Pleural effusion     21601258 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Colon tissue|Seminal fluid|Tongue tissue     - Extracellular vesicle Plasma     32498409 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	MALT1	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-200c-3p	7-Hydroxystaurosporine 72271 Drug resistant Fludarabine 657237 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive Cuspidatin C 5459164 Drug sensitive Simvastatin 54454 Drug resistant Lovastatin 53232 Drug resistant Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive Phomazarin 318385 Drug resistant Camptothecin Derivative - Drug resistant crotoxin cd - Drug resistant arylmethylene-f - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-200c-3p	N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide 9826528 Drug interaction    RC00003655 10-Hydroxycamptothecin 97226 Drug interaction    RC00003635 Curcumin 969516 Drug interaction    RC00003650 Hyaluronidase 91820602 Drug interaction    RC00003659 Cianidanol 9064 Drug interaction    RC00003625 Hydrogen peroxide 784 Drug interaction    RC00003612 Tetrahydropalmatine 72301 Drug interaction    RC00003634 Oxaliplatine 6857599 Drug interaction    RC00003654 Cytarabine 6253 Drug interaction    RC00003624 Alocrest 60780 Drug interaction    RC00003633 Gemcitabine 60750 Drug interaction    RC00003632 Vincristine 5978 Drug interaction    RC00003623 Dehydroepiandrosterone 5881 Drug interaction    RC00003622 D-Glucose 5793 Drug interaction    RC00003621 Estradiol 5757 Drug interaction    RC00003620 Prednisolone 5755 Drug interaction    RC00003619 RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00003646 Eloxatine 5310940 Drug interaction    RC00003653 Imatinib 5291 Drug interaction    RC00003618 Mephedrone 45266826 Drug interaction    RC00003658 Epothilone B 448013 Drug interaction    RC00003649 Resveratrol 445154 Drug interaction    RC00003648 Trichostatin A 444732 Drug interaction    RC00003645 Cyclopamine 442972 Drug interaction    RC00003644 Epirubicin 41867 Drug interaction    RC00003631 Metformin 4091 Drug interaction    RC00003617 Carboplatinum 38904 Drug interaction    RC00003630 Bortezomib 387447 Drug interaction    RC00003643 Paclitaxel 36314 Drug interaction    RC00003629 5-Fluorouracil 3385 Drug interaction    RC00003616 Doxorubicin 31703 Drug interaction    RC00003628 Daunorubicin 30323 Drug interaction    RC00003627 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene 3006531 Drug interaction    RC00003652 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003615 Tamoxifen 2733526 Drug interaction    RC00003651 Carmustine 2578 Drug interaction    RC00003614 Verapamil 2520 Drug interaction    RC00003613 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003657 Nandrolone phenpropionate 229455 Drug interaction    RC00003642 Sorafenib 216239 Drug interaction    RC00003641 Erlotinib 176870 Drug interaction    RC00003640 Arsenic trioxide 14888 Drug interaction    RC00003626 Docetaxel 148124 Drug interaction    RC00003639 Methotrexate 126941 Drug interaction    RC00003638 Gefitinib 123631 Drug interaction    RC00003637 Epoxomicin 11226684 Drug interaction    RC00003656 Fulvestrant 104741 Drug interaction    RC00003636 Asparaginase Escherichia coli - Drug interaction    RC00003660 Trastuzumab - Drug interaction    RC00003661 CDF(analogues of curcumin) - Drug interaction    RC00003662 CDF(analogues of curcumin) + gemcitabine - Drug interaction    RC00003663 DNA methyltransferases (DNMTs) + 5-azacytidine (5-AzaC) - Drug interaction    RC00003664 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00003665 Marine fungal metabolite 1386A - Drug interaction    RC00003666 Paclitaxel + Cyclopamine - Drug interaction    RC00003667 Chemotherapy - Drug interaction    RC00008849

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-200c-3p	Paclitaxel 36314       26323677 Paclitaxel 36314       30272330 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200c-3p
Interactor2: MALT1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.