Basic Information:

  VIRBase ID:  

HHID00054088

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-3p:  MIMAT0000510          DDIAS:  NM_001363481     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320a-3p	DDIAS
miRBase Accession/Entrez ID	MIMAT0000510	220042
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C11orf82//noxin

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320a-3p	rs1276783280 chr8:22244983    T/C rs1304651256 chr8:22244976    C/A rs1335522641 chr8:22244984    C/G rs1342806696 chr8:22244985    A/T rs1380599305 chr8:22244977    G/A rs376090584 chr8:22244982    C/T rs745462427 chr8:22244996    T/A rs745462427 chr8:22244996    T/C rs778232802 chr8:22244988    C/A rs778232802 chr8:22244988    C/T rs1029283088 chr8:22244995    T/C rs1272164828 chr8:22244990    A/G rs1295910991 chr8:22244991    G/C rs1311220991 chr8:22244994    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDIAS	chr11:82637201(+) A-I      intronic chr11:82637193(+) A-I      intronic chr11:82636542(+) A-I      intronic chr11:82636457(+) A-I      intronic chr11:82635812(+) A-I      intronic chr11:82637258(+) A-I      intronic chr11:82637232(+) A-I      intronic chr11:82637226(+) A-I      intronic chr11:82637257(+) A-I      intronic chr11:82639448(+) A-I      intronic chr11:82636951(+) A-I      intronic chr11:82636424(+) A-I      intronic chr11:82636437(+) A-I      intronic chr11:82636430(+) A-I      intronic chr11:82636489(+) A-I      intronic chr11:82637340(+) A-I      intronic chr11:82635583(+) A-I      intronic chr11:82635588(+) A-I      intronic chr11:82637331(+) A-I      intronic chr11:82635585(+) A-I      intronic chr11:82637405(+) A-I      intronic chr11:82636375(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDIAS	chr11:82620301-82620302(+) m6A 5'UTR//intron       24981863 chr11:82642793-82642794(+) m6A CDS//exon       24284625//22608085 chr11:82642885-82642886(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr11:82642938-82642939(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr11:82642955-82642956(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr11:82643165-82643166(+) m6A 3'UTR//CDS//intron       24284625//24209618//22608085 chr11:82643197-82643198(+) m6A 3'UTR//CDS//intron       24284625//24209618//22608085 chr11:82643321-82643322(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82643749-82643750(+) m6A 3'UTR//CDS//intron       24981863 chr11:82643781-82643782(+) m6A 3'UTR//CDS//intron       24981863 chr11:82643845-82643846(+) m6A 3'UTR//CDS//intron       24981863 chr11:82644215-82644216(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644238-82644239(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644269-82644270(+) m6A 3'UTR//CDS//intron       24981863//22608085 chr11:82644288-82644289(+) m6A 3'UTR//CDS//intron       24981863//26404942//22608085 chr11:82644344-82644345(+) m6A 3'UTR//CDS//intron       24284625//24981863//26404942//27773535//22608085 chr11:82644442-82644443(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr11:82644495-82644496(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//22608085 chr11:82644556-82644557(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644618-82644619(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644679-82644680(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644726-82644727(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644745-82644746(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644761-82644762(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644827-82644828(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82644864-82644865(+) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:82644954-82644955(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645091-82645092(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645097-82645098(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645106-82645107(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645113-82645114(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645179-82645180(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645228-82645229(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82645271-82645272(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:82645341-82645342(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:82645389-82645390(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr11:82645402-82645403(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22608085 chr11:82645465-82645466(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085 chr11:82645490-82645491(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085 chr11:82645495-82645496(+) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320a-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cardiomyocytes     31837603 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Pooled sera     27278097 Exosome Serum     18589210 Exosome Glioblastoma cells     19011622 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells     27396686 Mitochondrion HEK-293 cells|HeLa cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Cardiomyocytes     31837603 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Neural progenitor cells     21363885
	DDIAS	Exosome Blood     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320a-3p
Interactor2: DDIAS

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.