Basic Information:

  VIRBase ID:  

HHID00054086

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-3p:  MIMAT0000510          PDE12:  NM_001322177     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320a-3p	PDE12
miRBase Accession/Entrez ID	MIMAT0000510	201626
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	2'-PDE//2-PDE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320a-3p	rs1276783280 chr8:22244983    T/C rs1304651256 chr8:22244976    C/A rs1335522641 chr8:22244984    C/G rs1342806696 chr8:22244985    A/T rs1380599305 chr8:22244977    G/A rs376090584 chr8:22244982    C/T rs745462427 chr8:22244996    T/A rs745462427 chr8:22244996    T/C rs778232802 chr8:22244988    C/A rs778232802 chr8:22244988    C/T rs1029283088 chr8:22244995    T/C rs1272164828 chr8:22244990    A/G rs1295910991 chr8:22244991    G/C rs1311220991 chr8:22244994    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE12	chr3:57544801(+) A-I      intronic chr3:57546192(+) A-I      3'UTR chr3:57546182(+) A-I      3'UTR chr3:57546153(+) A-I      3'UTR chr3:57546152(+) A-I      3'UTR chr3:57544357(+) A-I      intronic chr3:57544271(+) A-I      intronic chr3:57544889(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE12	chr3:57544357(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE12	chr3:57542193-57542194(+) m6A CDS       24284625 chr3:57542243-57542244(+) m6A CDS       24284625 chr3:57542290-57542291(+) m6A CDS       24284625 chr3:57542603-57542604(+) m6A CDS       24284625//22575960 chr3:57542651-57542652(+) m6A CDS       24284625//22575960//22608085 chr3:57542781-57542782(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr3:57542787-57542788(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:57543019-57543020(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543033-57543034(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543103-57543104(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543119-57543120(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr3:57543344-57543345(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57543356-57543357(+) m6A CDS       24284625//24981863//26404942//22608085 chr3:57545061-57545062(+) m6A CDS       24284625//24981863//22608085 chr3:57545147-57545148(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545207-57545208(+) m6A 3'UTR//intron       24284625//22608085 chr3:57545244-57545245(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr3:57545337-57545338(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545387-57545388(+) m6A 3'UTR//CDS       24284625//24981863//26404942//22608085 chr3:57545459-57545460(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085 chr3:57545538-57545539(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr3:57545619-57545620(+) m6A 3'UTR//CDS       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320a-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cardiomyocytes     31837603 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Pooled sera     27278097 Exosome Serum     18589210 Exosome Glioblastoma cells     19011622 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells     27396686 Mitochondrion HEK-293 cells|HeLa cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Cardiomyocytes     31837603 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Neural progenitor cells     21363885
	PDE12	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320a-3p
Interactor2: PDE12

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.