Basic Information:

  VIRBase ID:  

HHID00054065

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-3p:  MIMAT0000510          PCNP:  NM_020357     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320a-3p	PCNP
miRBase Accession/Entrez ID	MIMAT0000510	57092
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320a-3p	rs1276783280 chr8:22244983    T/C rs1304651256 chr8:22244976    C/A rs1335522641 chr8:22244984    C/G rs1342806696 chr8:22244985    A/T rs1380599305 chr8:22244977    G/A rs376090584 chr8:22244982    C/T rs745462427 chr8:22244996    T/A rs745462427 chr8:22244996    T/C rs778232802 chr8:22244988    C/A rs778232802 chr8:22244988    C/T rs1029283088 chr8:22244995    T/C rs1272164828 chr8:22244990    A/G rs1295910991 chr8:22244991    G/C rs1311220991 chr8:22244994    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PCNP	chr3:101302194(+) A-I      intronic chr3:101305965(+) A-I      intronic chr3:101302183(+) A-I      intronic chr3:101295460(+) A-I      intronic chr3:101295442(+) A-I      intronic chr3:101307004(+) A-I      intronic chr3:101309450(+) A-I      intronic chr3:101309452(+) A-I      intronic chr3:101295441(+) A-I      intronic chr3:101302114(+) A-I      intronic chr3:101302090(+) A-I      intronic chr3:101300430(+) A-I      intronic chr3:101305507(+) A-I      intronic chr3:101305504(+) A-I      intronic chr3:101304927(+) A-I      intronic chr3:101302609(+) A-I      intronic chr3:101302531(+) A-I      intronic chr3:101302572(+) A-I      intronic chr3:101306961(+) A-I      intronic chr3:101308335(+) A-I      intronic chr3:101308412(+) A-I      intronic chr3:101308490(+) A-I      intronic chr3:101305686(+) A-I      intronic chr3:101304936(+) A-I      intronic chr3:101304904(+) A-I      intronic chr3:101304892(+) A-I      intronic chr3:101304884(+) A-I      intronic chr3:101304850(+) A-I      intronic chr3:101303813(+) A-I      intronic chr3:101303558(+) A-I      intronic chr3:101303539(+) A-I      intronic chr3:101303534(+) A-I      intronic chr3:101303526(+) A-I      intronic chr3:101303509(+) A-I      intronic chr3:101303508(+) A-I      intronic chr3:101303430(+) A-I      intronic chr3:101303245(+) A-I      intronic chr3:101302760(+) A-I      intronic chr3:101302704(+) A-I      intronic chr3:101302519(+) A-I      intronic chr3:101302349(+) A-I      intronic chr3:101302223(+) A-I      intronic chr3:101302213(+) A-I      intronic chr3:101302204(+) A-I      intronic chr3:101302177(+) A-I      intronic chr3:101302167(+) A-I      intronic chr3:101302155(+) A-I      intronic chr3:101302067(+) A-I      intronic chr3:101302045(+) A-I      intronic chr3:101301146(+) A-I      intronic chr3:101301136(+) A-I      intronic chr3:101301082(+) A-I      intronic chr3:101300836(+) A-I      intronic chr3:101300702(+) A-I      intronic chr3:101300685(+) A-I      intronic chr3:101300684(+) A-I      intronic chr3:101300500(+) A-I      intronic chr3:101311143(+) A-I      intronic chr3:101300443(+) A-I      intronic chr3:101300295(+) A-I      intronic chr3:101311135(+) A-I      intronic chr3:101304786(+) A-I      intronic chr3:101306955(+) A-I      intronic chr3:101306995(+) A-I      intronic chr3:101308294(+) A-I      intronic chr3:101308329(+) A-I      intronic chr3:101311118(+) A-I      intronic chr3:101305618(+) A-I      intronic chr3:101311111(+) A-I      intronic chr3:101309420(+) A-I      intronic chr3:101309412(+) A-I      intronic chr3:101305636(+) A-I      intronic chr3:101309410(+) A-I      intronic chr3:101304940(+) A-I      intronic chr3:101305990(+) A-I      intronic chr3:101304975(+) A-I      intronic chr3:101305542(+) A-I      intronic chr3:101305996(+) A-I      intronic chr3:101306035(+) A-I      intronic chr3:101306836(+) A-I      intronic chr3:101306862(+) A-I      intronic chr3:101306913(+) A-I      intronic chr3:101306949(+) A-I      intronic chr3:101306953(+) A-I      intronic chr3:101306954(+) A-I      intronic chr3:101308499(+) A-I      intronic chr3:101302621(+) A-I      intronic chr3:101302425(+) A-I      intronic chr3:101302716(+) A-I      intronic chr3:101305899(+) A-I      intronic chr3:101305935(+) A-I      intronic chr3:101303803(+) A-I      intronic chr3:101299178(+) A-I      intronic chr3:101301274(+) A-I      intronic chr3:101304868(+) A-I      intronic chr3:101308518(+) A-I      intronic chr3:101305987(+) A-I      intronic chr3:101305934(+) A-I      intronic chr3:101308384(+) A-I      intronic chr3:101309653(+) A-I      intronic chr3:101301121(+) A-I      intronic chr3:101302548(+) A-I      intronic chr3:101305979(+) A-I      intronic chr3:101305936(+) A-I      intronic chr3:101299228(+) A-I      intronic chr3:101303790(+) A-I      intronic chr3:101300475(+) A-I      intronic chr3:101302631(+) A-I      intronic chr3:101301916(+) A-I      intronic chr3:101309576(+) A-I      intronic chr3:101306077(+) A-I      intronic chr3:101302337(+) A-I      intronic chr3:101306015(+) A-I      intronic chr3:101301176(+) A-I      intronic chr3:101303727(+) A-I      intronic chr3:101305536(+) A-I      intronic chr3:101300714(+) A-I      intronic chr3:101305947(+) A-I      intronic chr3:101304921(+) A-I      intronic chr3:101305568(+) A-I      intronic chr3:101306033(+) A-I      intronic chr3:101301962(+) A-I      intronic chr3:101306043(+) A-I      intronic chr3:101306006(+) A-I      intronic chr3:101309894(+) A-I      intronic chr3:101304751(+) A-I      intronic chr3:101309583(+) A-I      intronic chr3:101300395(+) A-I      intronic chr3:101307060(+) A-I      intronic chr3:101301245(+) A-I      intronic chr3:101305843(+) A-I      intronic chr3:101305670(+) A-I      intronic chr3:101305039(+) A-I      intronic chr3:101306026(+) A-I      intronic chr3:101302513(+) A-I      intronic chr3:101301946(+) A-I      intronic chr3:101305973(+) A-I      intronic chr3:101303460(+) A-I      intronic chr3:101303416(+) A-I      intronic chr3:101303836(+) A-I      intronic chr3:101301182(+) A-I      intronic chr3:101305888(+) A-I      intronic chr3:101301218(+) A-I      intronic chr3:101300334(+) A-I      intronic chr3:101302511(+) A-I      intronic chr3:101306014(+) A-I      intronic chr3:101303798(+) A-I      intronic chr3:101301145(+) A-I      intronic chr3:101303835(+) A-I      intronic chr3:101308359(+) A-I      intronic chr3:101305572(+) A-I      intronic chr3:101304965(+) A-I      intronic chr3:101305529(+) A-I      intronic chr3:101295868(+) A-I      intronic chr3:101305974(+) A-I      intronic chr3:101301908(+) A-I      intronic chr3:101311073(+) A-I      intronic chr3:101302785(+) A-I      intronic chr3:101307065(+) A-I      intronic chr3:101303535(+) A-I      intronic chr3:101305506(+) A-I      intronic chr3:101300419(+) A-I      intronic chr3:101304737(+) A-I      intronic chr3:101305631(+) A-I      intronic chr3:101303564(+) A-I      intronic chr3:101308396(+) A-I      intronic chr3:101302515(+) A-I      intronic chr3:101302178(+) A-I      intronic chr3:101309528(+) A-I      intronic chr3:101308355(+) A-I      intronic chr3:101302037(+) A-I      intronic chr3:101303709(+) A-I      intronic chr3:101303683(+) A-I      intronic chr3:101301044(+) A-I      intronic chr3:101302339(+) A-I      intronic chr3:101295854(+) A-I      intronic chr3:101301088(+) A-I      intronic chr3:101301203(+) A-I      intronic chr3:101302104(+) A-I      intronic chr3:101302285(+) A-I      intronic chr3:101306000(+) A-I      intronic chr3:101301894(+) A-I      intronic chr3:101304970(+) A-I      intronic chr3:101301914(+) A-I      intronic chr3:101302086(+) A-I      intronic chr3:101302068(+) A-I      intronic chr3:101301230(+) A-I      intronic chr3:101303489(+) A-I      intronic chr3:101304760(+) A-I      intronic chr3:101306968(+) A-I      intronic chr3:101300341(+) A-I      intronic chr3:101300377(+) A-I      intronic chr3:101308394(+) A-I      intronic chr3:101309655(+) A-I      intronic chr3:101305983(+) A-I      intronic chr3:101302410(+) A-I      intronic chr3:101305543(+) A-I      intronic chr3:101302447(+) A-I      intronic chr3:101303566(+) A-I      intronic chr3:101303542(+) A-I      intronic chr3:101303797(+) A-I      intronic chr3:101304814(+) A-I      intronic chr3:101300417(+) A-I      intronic chr3:101308277(+) A-I      intronic chr3:101305659(+) A-I      intronic chr3:101304759(+) A-I      intronic chr3:101302384(+) A-I      intronic chr3:101300433(+) A-I      intronic chr3:101302549(+) A-I      intronic chr3:101303643(+) A-I      intronic chr3:101300282(+) A-I      intronic chr3:101303750(+) A-I      intronic chr3:101304856(+) A-I      intronic chr3:101303763(+) A-I      intronic chr3:101300530(+) A-I      intronic chr3:101303622(+) A-I      intronic chr3:101307035(+) A-I      intronic chr3:101305632(+) A-I      intronic chr3:101301228(+) A-I      intronic chr3:101302014(+) A-I      intronic chr3:101302121(+) A-I      intronic chr3:101301276(+) A-I      intronic chr3:101299204(+) A-I      intronic chr3:101308530(+) A-I      intronic chr3:101308508(+) A-I      intronic chr3:101302782(+) A-I      intronic chr3:101305569(+) A-I      intronic chr3:101300724(+) A-I      intronic chr3:101302219(+) A-I      intronic chr3:101302141(+) A-I      intronic chr3:101303452(+) A-I      intronic chr3:101300444(+) A-I      intronic chr3:101305957(+) A-I      intronic chr3:101300858(+) A-I      intronic chr3:101309573(+) A-I      intronic chr3:101302442(+) A-I      intronic chr3:101295851(+) A-I      intronic chr3:101301132(+) A-I      intronic chr3:101305555(+) A-I      intronic chr3:101300322(+) A-I      intronic chr3:101301240(+) A-I      intronic chr3:101305658(+) A-I      intronic chr3:101301186(+) A-I      intronic chr3:101301065(+) A-I      intronic chr3:101303548(+) A-I      intronic chr3:101300641(+) A-I      intronic chr3:101309614(+) A-I      intronic chr3:101303749(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PCNP	chr3:101301914(+) A-I intron -    22327324 chr3:101303835(+) A-I intron -    22327324 chr3:101305501(+) A-I intron -    22327324 chr3:101305522(+) A-I intron -    22327324 chr3:101305888(+) A-I intron -    22028664 chr3:101305899(+) A-I intron -    22028664 chr3:101305934(+) A-I intron -    22028664 chr3:101305935(+) A-I intron -    22028664 chr3:101305936(+) A-I intron -    22028664 chr3:101305947(+) A-I intron -    22028664 chr3:101305957(+) A-I intron -    22028664 chr3:101305974(+) A-I intron -    22028664 chr3:101305979(+) A-I intron -    22028664 chr3:101305987(+) A-I intron -    22028664 chr3:101306000(+) A-I intron -    22028664 chr3:101306006(+) A-I intron -    22028664 chr3:101306014(+) A-I intron -    22028664 chr3:101306015(+) A-I intron -    22028664 chr3:101306026(+) A-I intron -    22028664 chr3:101306033(+) A-I intron -    22028664 chr3:101306043(+) A-I intron -    22028664 chr3:101306077(+) A-I intron -    22028664 chr3:101303165(+) A-I intron -    21960545 chr3:101303760(+) A-I intron -    21960545 chr3:101295186(+) T-C intron -    22484847 chr3:101300377(+) A-G intron -    22484847 chr3:101300407(+) A-G intron -    22484847 chr3:101300530(+) A-G intron -    22484847 chr3:101300641(+) A-G intron -    22484847 chr3:101301065(+) A-G intron -    22484847 chr3:101301087(+) A-G intron -    22484847 chr3:101301121(+) A-G intron -    22484847 chr3:101301132(+) A-G intron -    22484847 chr3:101301135(+) A-G intron -    22484847 chr3:101301176(+) A-G intron -    22484847 chr3:101301182(+) A-G intron -    22484847 chr3:101301186(+) A-G intron -    22484847 chr3:101301244(+) A-G intron -    22484847 chr3:101301908(+) A-G intron -    22484847 chr3:101301914(+) A-G intron -    22484847 chr3:101301916(+) A-G intron -    22484847 chr3:101301917(+) A-G intron -    22484847 chr3:101301987(+) A-G intron -    22484847 chr3:101302037(+) A-G intron -    22484847 chr3:101302068(+) A-G intron -    22484847 chr3:101302086(+) A-G intron -    22484847 chr3:101302118(+) A-G intron -    22484847 chr3:101302138(+) G-A intron -    22484847 chr3:101302178(+) A-G intron -    22484847 chr3:101302187(+) A-G intron -    22484847 chr3:101302548(+) A-G intron -    22484847 chr3:101302631(+) A-G intron -    22484847 chr3:101302716(+) A-G intron -    22484847 chr3:101302782(+) A-G intron -    22484847 chr3:101302785(+) A-G intron -    22484847 chr3:101303440(+) A-G intron -    22484847 chr3:101303749(+) A-G intron -    22484847 chr3:101303750(+) A-G intron -    22484847 chr3:101303760(+) A-G intron -    22484847 chr3:101303763(+) A-G intron -    22484847 chr3:101303790(+) A-G intron -    22484847 chr3:101303835(+) A-G intron -    22484847 chr3:101305501(+) A-G intron -    22484847 chr3:101305522(+) A-G intron -    22484847 chr3:101305536(+) A-G intron -    22484847 chr3:101305543(+) A-G intron -    22484847 chr3:101305617(+) A-G intron -    22484847 chr3:101305957(+) A-G intron -    22484847 chr3:101305983(+) A-G intron -    22484847 chr3:101306014(+) A-G intron -    22484847 chr3:101306015(+) A-G intron -    22484847 chr3:101306994(+) A-G intron -    22484847 chr3:101307035(+) A-G intron -    22484847 chr3:101308268(+) C-T intron -    22484847 chr3:101308316(+) A-G intron -    22484847 chr3:101308350(+) A-G intron -    22484847 chr3:101308359(+) A-G intron -    22484847 chr3:101308396(+) A-G intron -    22484847 chr3:101308428(+) A-G intron -    22484847 chr3:101309567(+) A-T intron -    22484847 chr3:101311073(+) A-G intron -    22484847 chr3:101311080(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCNP	chr3:101292953-101292954(+) m6A 5'UTR       25456834 chr3:101292991-101292992(+) m6A 5'UTR       25456834//24981863//22608085 chr3:101298494-101298495(+) m6A 3'UTR//intron       24981863 chr3:101298506-101298507(+) m6A 3'UTR//intron       24981863 chr3:101298634-101298635(+) m6A 3'UTR//CDS//exon//intron       25456834//24981863 chr3:101298642-101298643(+) m1A 3'UTR//CDS//exon//intron       26863196 chr3:101298655-101298656(+) m6A 3'UTR//CDS//exon//intron       25456834//24981863 chr3:101298665-101298666(+) m6A 3'UTR//CDS//exon//intron       24981863 chr3:101298671-101298672(+) m6A 3'UTR//CDS//exon//intron       24981863 chr3:101298735-101298736(+) m1A 3'UTR//CDS//exon//intron       26863196 chr3:101298835-101298836(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:101304292-101304293(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863//27773535 chr3:101304316-101304317(+) m6A 3'UTR//5'UTR//CDS//exon//intron       27773535 chr3:101312791-101312792(+) m6A 3'UTR       27773535 chr3:101312815-101312816(+) m6A 3'UTR       27773535 chr3:101312841-101312842(+) m6A 3'UTR       27773535 chr3:101313118-101313119(+) m6A 3'UTR       27773535 chr3:101313275-101313276(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320a-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cardiomyocytes     31837603 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Pooled sera     27278097 Exosome Serum     18589210 Exosome Glioblastoma cells     19011622 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells     27396686 Mitochondrion HEK-293 cells|HeLa cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Cardiomyocytes     31837603 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Neural progenitor cells     21363885
	PCNP	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320a-3p
Interactor2: PCNP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.