Basic Information:

  VIRBase ID:  

HHID00054052

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-3p:  MIMAT0000510          THUMPD3:  NM_015453     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-320a-3p	THUMPD3
miRBase Accession/Entrez ID	MIMAT0000510	25917
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-320a-3p	rs1276783280 chr8:22244983    T/C rs1304651256 chr8:22244976    C/A rs1335522641 chr8:22244984    C/G rs1342806696 chr8:22244985    A/T rs1380599305 chr8:22244977    G/A rs376090584 chr8:22244982    C/T rs745462427 chr8:22244996    T/A rs745462427 chr8:22244996    T/C rs778232802 chr8:22244988    C/A rs778232802 chr8:22244988    C/T rs1029283088 chr8:22244995    T/C rs1272164828 chr8:22244990    A/G rs1295910991 chr8:22244991    G/C rs1311220991 chr8:22244994    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	THUMPD3	chr3:9409965(+) A-I      intronic chr3:9412208(+) A-I      intronic chr3:9412222(+) A-I      intronic chr3:9412232(+) A-I      intronic chr3:9412241(+) A-I      intronic chr3:9414219(+) A-I      intronic chr3:9414170(+) A-I      intronic chr3:9413701(+) A-I      intronic chr3:9426638(+) A-I      3'UTR chr3:9426588(+) A-I      3'UTR chr3:9426592(+) A-I      3'UTR chr3:9426598(+) A-I      3'UTR chr3:9414179(+) A-I      intronic chr3:9413640(+) A-I      intronic chr3:9413630(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	THUMPD3	chr3:9404916-9404917(+) m6A 5'UTR//intron       27773536 chr3:9405245-9405246(+) m6A 5'UTR//intron       24981863 chr3:9406795-9406796(+) m6A CDS       27773535 chr3:9406807-9406808(+) m6A CDS       27773535 chr3:9408659-9408660(+) m6A CDS       27773535 chr3:9412768-9412769(+) m6A CDS       24981863//27773535//22608085 chr3:9412781-9412782(+) m6A CDS       24981863//27773535//22608085 chr3:9412795-9412796(+) m6A CDS       24981863//27773535//22608085 chr3:9412895-9412896(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr3:9413046-9413047(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9413070-9413071(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9413123-9413124(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:9416209-9416210(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr3:9426329-9426330(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426348-9426349(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426425-9426426(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426453-9426454(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426474-9426475(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:9426548-9426549(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr3:9426959-9426960(+) m6A 3'UTR       27773535 chr3:9427303-9427304(+) m6A 3'UTR       27773535 chr3:9427346-9427347(+) m6A 3'UTR       27773535 chr3:9427354-9427355(+) m6A 3'UTR       27773535 chr3:9427409-9427410(+) m6A 3'UTR       27773535 chr3:9427414-9427415(+) m6A 3'UTR       27773535 chr3:9427420-9427421(+) m6A 3'UTR       27773535 chr3:9427490-9427491(+) m6A 3'UTR       24981863//27773535 chr3:9427612-9427613(+) m6A 3'UTR       24981863//27773535 chr3:9427641-9427642(+) m6A 3'UTR       27773535 chr3:9427976-9427977(+) m6A 3'UTR       - chr3:9427985-9427986(+) m6A 3'UTR       - chr3:9428009-9428010(+) m6A 3'UTR       - chr3:9428025-9428026(+) m6A 3'UTR       - chr3:9428423-9428424(+) m6A 3'UTR       27773535 chr3:9428467-9428468(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-320a-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cardiomyocytes     31837603 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Pooled sera     27278097 Exosome Serum     18589210 Exosome Glioblastoma cells     19011622 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells     27396686 Mitochondrion HEK-293 cells|HeLa cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Cardiomyocytes     31837603 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Neural progenitor cells     21363885
	THUMPD3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-320a-3p
Interactor2: THUMPD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.