Detail Information

Basic Information:


  VIRBase ID:  

HHID00054019

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-320a-3p:           PPM1A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320a-3p PPM1A
miRBase
Accession/Entrez ID		 MIMAT0000510 5494
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PP2C-ALPHA//PP2CA//PP2Calpha

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320a-3p
rs1276783280 chr8:22244983    T/C
rs1304651256 chr8:22244976    C/A
rs1335522641 chr8:22244984    C/G
rs1342806696 chr8:22244985    A/T
rs1380599305 chr8:22244977    G/A
rs376090584 chr8:22244982    C/T
rs745462427 chr8:22244996    T/A
rs745462427 chr8:22244996    T/C
rs778232802 chr8:22244988    C/A
rs778232802 chr8:22244988    C/T
rs1029283088 chr8:22244995    T/C
rs1272164828 chr8:22244990    A/G
rs1295910991 chr8:22244991    G/C
rs1311220991 chr8:22244994    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PPM1A
chr14:60742334(+) A-I      intronic
chr14:60722951(+) A-I      intronic
chr14:60722096(+) A-I      intronic
chr14:60740661(+) A-I      intronic
chr14:60722007(+) A-I      intronic
chr14:60740585(+) A-I      intronic
chr14:60721970(+) A-I      intronic
chr14:60721954(+) A-I      intronic
chr14:60721945(+) A-I      intronic
chr14:60739191(+) A-I      intronic
chr14:60721940(+) A-I      intronic
chr14:60723101(+) A-I      intronic
chr14:60723121(+) A-I      intronic
chr14:60742305(+) A-I      intronic
chr14:60722921(+) A-I      intronic
chr14:60729794(+) A-I      intronic
chr14:60721913(+) A-I      intronic
chr14:60736292(+) A-I      intronic
chr14:60729220(+) A-I      intronic
chr14:60729829(+) A-I      intronic
chr14:60729815(+) A-I      intronic
chr14:60729733(+) A-I      intronic
chr14:60729698(+) A-I      intronic
chr14:60729690(+) A-I      intronic
chr14:60729384(+) A-I      intronic
chr14:60729304(+) A-I      intronic
chr14:60729263(+) A-I      intronic
chr14:60742222(+) A-I      intronic
chr14:60729130(+) A-I      intronic
chr14:60723111(+) A-I      intronic
chr14:60742241(+) A-I      intronic
chr14:60723057(+) A-I      intronic
chr14:60723054(+) A-I      intronic
chr14:60722983(+) A-I      intronic
chr14:60722978(+) A-I      intronic
chr14:60722906(+) A-I      intronic
chr14:60722163(+) A-I      intronic
chr14:60722100(+) A-I      intronic
chr14:60739169(+) A-I      intronic
chr14:60722922(+) A-I      intronic
chr14:60742452(+) A-I      intronic
chr14:60740658(+) A-I      intronic
chr14:60746779(+) A-I      intronic
chr14:60722975(+) A-I      intronic
chr14:60729372(+) A-I      intronic
chr14:60723072(+) A-I      intronic
chr14:60739170(+) A-I      intronic
chr14:60742266(+) A-I      intronic
chr14:60739280(+) A-I      intronic
chr14:60740570(+) A-I      intronic
chr14:60740587(+) A-I      intronic
chr14:60729734(+) A-I      intronic
chr14:60723031(+) A-I      intronic
chr14:60742451(+) A-I      intronic
chr14:60722976(+) A-I      intronic
chr14:60729885(+) A-I      intronic
chr14:60722910(+) A-I      intronic
chr14:60722884(+) A-I      intronic
chr14:60722861(+) A-I      intronic
chr14:60729257(+) A-I      intronic
chr14:60723137(+) A-I      intronic
chr14:60729243(+) A-I      intronic
chr14:60722927(+) A-I      intronic
chr14:60742338(+) A-I      intronic
chr14:60740594(+) A-I      intronic
chr14:60742442(+) A-I      intronic
chr14:60729139(+) A-I      intronic
chr14:60722883(+) A-I      intronic
chr14:60723100(+) A-I      intronic
chr14:60722980(+) A-I      intronic
chr14:60729279(+) A-I      intronic
chr14:60729880(+) A-I      intronic
chr14:60722977(+) A-I      intronic
chr14:60723045(+) A-I      intronic
chr14:60742322(+) A-I      intronic
chr14:60723063(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PPM1A
chr14:60723100(+) A-I intron -    22327324
chr14:60742222(+) A-I intron -    22327324
chr14:60722884(+) A-G intron -    22484847
chr14:60722910(+) A-G intron -    22484847
chr14:60723100(+) A-G intron -    22484847
chr14:60723121(+) A-G intron -    22484847
chr14:60729880(+) A-G intron -    22484847
chr14:60740658(+) A-G intron -    22484847
chr14:60742222(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PPM1A
chr14:60712722-60712723(+) m6A CDS       24981863
chr14:60712760-60712761(+) m6A CDS       24981863
chr14:60716090-60716091(+) m6A 5'UTR//intron       24209618//24981863
chr14:60716097-60716098(+) m6A 5'UTR//intron       24209618//24981863
chr14:60716151-60716152(+) m6A 5'UTR//intron       24209618//24981863//27773536
chr14:60716370-60716371(+) m6A 5'UTR//intron       24284625//24209618//24981863
chr14:60717108-60717109(+) m6A 5'UTR//intron       24284625//24209618//24981863
chr14:60717130-60717131(+) m6A 5'UTR//intron       24284625//24209618//24981863
chr14:60743793-60743794(+) m6A 5'UTR//CDS//intron       24209618
chr14:60744054-60744055(+) m6A 5'UTR//intron       24209618//24981863
chr14:60744073-60744074(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085
chr14:60749416-60749417(+) m6A 3'UTR//5'UTR//CDS       24284625//24209618//24981863//22608085
chr14:60749437-60749438(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr14:60749567-60749568(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr14:60749727-60749728(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60749750-60749751(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60749777-60749778(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60749857-60749858(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60749881-60749882(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60749915-60749916(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr14:60752432-60752433(+) m6A 3'UTR//CDS       27773535
chr14:60752518-60752519(+) m6A 3'UTR//intron       24981863
chr14:60755258-60755259(+) m6A 3'UTR//intron       24209618
chr14:60755267-60755268(+) m6A 3'UTR//intron       24209618
chr14:60756592-60756593(+) m6A 3'UTR//CDS       24209618
chr14:60758144-60758145(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr14:60759201-60759202(+) m6A 3'UTR       24284625//24981863//22608085
chr14:60759266-60759267(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:60759334-60759335(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr14:60759362-60759363(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr14:60759395-60759396(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr14:60759417-60759418(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr14:60759441-60759442(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320a-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cardiomyocytes     31837603
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Pooled sera     27278097
Exosome Serum     18589210
Exosome Glioblastoma cells     19011622
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25135963
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Glioblastoma cells     19011622
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion HEK-293 cells|HeLa cells     27396686
Mitochondrion HEK-293 cells|HeLa cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Cardiomyocytes     31837603
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Neural progenitor cells     21363885
PPM1A
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320a-3p
Interactor2: PPM1A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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