Detail Information

Basic Information:


  VIRBase ID:  

HHID00053971

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           DHX36:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p DHX36
miRBase
Accession/Entrez ID		 MIMAT0000461 170506
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DDX36//G4R1//MLEL1//RHAU

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHX36
chr3:154013760(-) A-I      intronic
chr3:154013730(-) A-I      intronic
chr3:154013776(-) A-I      intronic
chr3:154014019(-) A-I      intronic
chr3:154014021(-) A-I      intronic
chr3:154014082(-) A-I      intronic
chr3:154014163(-) A-I      intronic
chr3:154014176(-) A-I      intronic
chr3:154004725(-) A-I      intronic
chr3:154014187(-) A-I      intronic
chr3:153993280(-) A-I      3'UTR
chr3:154004729(-) A-I      intronic
chr3:154013654(-) A-I      intronic
chr3:154013751(-) A-I      intronic
chr3:154013824(-) A-I      intronic
chr3:154016950(-) A-I      intronic
chr3:154016881(-) A-I      intronic
chr3:154013821(-) A-I      intronic
chr3:154002243(-) A-I      intronic
chr3:153991878(-) A-I      3'UTR
chr3:153992014(-) A-I      3'UTR
chr3:154015391(-) A-I      intronic
chr3:153996390(-) A-I      intronic
chr3:154013752(-) A-I      intronic
chr3:154016523(-) A-I      intronic
chr3:154013649(-) A-I      intronic
chr3:154013642(-) A-I      intronic
chr3:154013685(-) A-I      intronic
chr3:154017065(-) A-I      intronic
chr3:154013619(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHX36
chr3:154013619(-) A-G intron -    22484847
chr3:154013642(-) A-G intron -    22484847
chr3:154013649(-) A-G intron -    22484847
chr3:154013745(-) A-G intron -    22484847
chr3:154013752(-) A-G intron -    22484847
chr3:154013753(-) A-G intron -    22484847
chr3:154014074(-) A-G intron -    22484847
chr3:154016523(-) A-G intron -    22484847
chr3:154016881(-) A-G intron -    22484847
chr3:154016890(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHX36
chr3:153992184-153992185(-) m6A 3'UTR       22608085
chr3:153992205-153992206(-) m6A 3'UTR       22608085
chr3:153992275-153992276(-) m6A 3'UTR       24981863//22608085
chr3:153992303-153992304(-) m6A 3'UTR       24981863//22608085
chr3:153992309-153992310(-) m6A 3'UTR       24981863//22608085
chr3:153992315-153992316(-) m6A 3'UTR       24981863//22608085
chr3:153992346-153992347(-) m6A 3'UTR       22608085
chr3:153993528-153993529(-) m6A 3'UTR       27773535
chr3:153993553-153993554(-) m6A 3'UTR       27773535
chr3:153993576-153993577(-) m6A 3'UTR       27773535
chr3:153993823-153993824(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr3:153993867-153993868(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr3:153993873-153993874(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153993881-153993882(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153993996-153993997(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994021-153994022(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994032-153994033(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994059-153994060(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994083-153994084(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994130-153994131(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994363-153994364(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:154018786-154018787(-) m6A CDS       24981863//27773535
chr3:154018846-154018847(-) m6A CDS       24981863//27773535
chr3:154018894-154018895(-) m6A CDS       24981863//27773535
chr3:154018903-154018904(-) m6A CDS       24981863//27773535
chr3:154027527-154027528(-) Y CDS       26075521
chr3:154029480-154029481(-) m6A exon//intron       27773535
chr3:154032895-154032896(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032902-154032903(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032912-154032913(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032961-154032962(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154033024-154033025(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085
chr3:154033042-154033043(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085
chr3:154033889-154033890(-) Y CDS//exon       25219674
chr3:154033916-154033917(-) m6A CDS//exon       24209618//24981863//27773535//27371828
chr3:154036929-154036930(-) m1A 5'UTR//intron       26863196
chr3:154036937-154036938(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828
chr3:154041984-154041985(-) m6A CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960
chr3:154041998-154041999(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr3:154042182-154042183(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr3:154042207-154042208(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
DHX36
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: DHX36

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...