Detail Information

Basic Information:


  VIRBase ID:  

HHID00053969

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           SPRED1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p SPRED1
miRBase
Accession/Entrez ID		 MIMAT0000461 161742
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - hSpred1//LGSS//NFLS//PPP1R147//spred-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPRED1
chr15:38597488(+) A-I      intronic
chr15:38597474(+) A-I      intronic
chr15:38597483(+) A-I      intronic
chr15:38597485(+) A-I      intronic
chr15:38649331(+) A-I      3'UTR
chr15:38597482(+) A-I      intronic
chr15:38617239(+) A-I      intronic
chr15:38573825(+) A-I      intronic
chr15:38570604(+) A-I      intronic
chr15:38562178(+) A-I      intronic
chr15:38570495(+) A-I      intronic
chr15:38571278(+) A-I      intronic
chr15:38562373(+) A-I      intronic
chr15:38562368(+) A-I      intronic
chr15:38574690(+) A-I      intronic
chr15:38570580(+) A-I      intronic
chr15:38571098(+) A-I      intronic
chr15:38571168(+) A-I      intronic
chr15:38574426(+) A-I      intronic
chr15:38597320(+) A-I      intronic
chr15:38597331(+) A-I      intronic
chr15:38617229(+) A-I      intronic
chr15:38574398(+) A-I      intronic
chr15:38617249(+) A-I      intronic
chr15:38567722(+) A-I      intronic
chr15:38567720(+) A-I      intronic
chr15:38624506(+) A-I      intronic
chr15:38564494(+) A-I      intronic
chr15:38570561(+) A-I      intronic
chr15:38595181(+) A-I      intronic
chr15:38578263(+) A-I      intronic
chr15:38567792(+) A-I      intronic
chr15:38570534(+) A-I      intronic
chr15:38570427(+) A-I      intronic
chr15:38574466(+) A-I      intronic
chr15:38573868(+) A-I      intronic
chr15:38597386(+) A-I      intronic
chr15:38573880(+) A-I      intronic
chr15:38567896(+) A-I      intronic
chr15:38578187(+) A-I      intronic
chr15:38567725(+) A-I      intronic
chr15:38562209(+) A-I      intronic
chr15:38601581(+) A-I      intronic
chr15:38570581(+) A-I      intronic
chr15:38638283(+) A-I      intronic
chr15:38601616(+) A-I      intronic
chr15:38567958(+) A-I      intronic
chr15:38574620(+) A-I      intronic
chr15:38570484(+) A-I      intronic
chr15:38573727(+) A-I      intronic
chr15:38573663(+) A-I      intronic
chr15:38548956(+) A-I      intronic
chr15:38624707(+) A-I      intronic
chr15:38567718(+) A-I      intronic
chr15:38570500(+) A-I      intronic
chr15:38567799(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SPRED1
chr15:38567718(+) A-I intron -    15342557
chr15:38567720(+) A-I intron -    15342557
chr15:38567722(+) A-I intron -    15342557
chr15:38567725(+) A-I intron -    15342557
chr15:38567792(+) A-I intron -    15342557
chr15:38567799(+) A-I intron -    15342557
chr15:38567896(+) A-I intron -    15342557
chr15:38567958(+) A-I intron -    15342557
chr15:38570022(+) A-I intron -    15342557
chr15:38570091(+) A-I intron -    15342557
chr15:38570427(+) A-I intron -    15342557
chr15:38570484(+) A-I intron -    15342557
chr15:38570500(+) A-I intron -    15342557
chr15:38570561(+) A-I intron -    15342557
chr15:38570581(+) A-I intron -    15342557
chr15:38570604(+) A-I intron -    15342557

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPRED1
chr15:38544636-38544637(+) m6A 5'UTR       -
chr15:38544810-38544811(+) m6A 5'UTR       25456834
chr15:38544885-38544886(+) m6A 5'UTR       25456834
chr15:38618211-38618212(+) m6A exon//intron       24981863
chr15:38618218-38618219(+) m6A exon//intron       24981863
chr15:38618224-38618225(+) m6A exon//intron       24981863
chr15:38618280-38618281(+) m6A exon//intron       24981863
chr15:38618345-38618346(+) m6A exon//intron       24981863
chr15:38632035-38632036(+) m6A CDS       -
chr15:38643234-38643235(+) m6A CDS       24981863//22608085
chr15:38643275-38643276(+) m6A CDS       24209618//24981863//22575960//22608085
chr15:38643308-38643309(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:38643315-38643316(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:38643381-38643382(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:38643386-38643387(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:38643401-38643402(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:38643427-38643428(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:38643449-38643450(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:38643599-38643600(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr15:38643674-38643675(+) m6A CDS       24284625//24981863//22575960//22608085
chr15:38644193-38644194(+) m6A 3'UTR       24981863//22608085
chr15:38644219-38644220(+) m6A 3'UTR       24981863//22608085
chr15:38644225-38644226(+) m6A 3'UTR       24981863//22608085
chr15:38644250-38644251(+) m6A 3'UTR       24981863//22608085
chr15:38644303-38644304(+) m6A 3'UTR       24981863
chr15:38646545-38646546(+) m6A 3'UTR       24981863
chr15:38646603-38646604(+) m6A 3'UTR       24981863//22608085
chr15:38646616-38646617(+) m6A 3'UTR       24981863//22608085
chr15:38646666-38646667(+) m6A 3'UTR       24981863//22608085
chr15:38646740-38646741(+) m6A 3'UTR       24981863//22608085
chr15:38646826-38646827(+) m6A 3'UTR       24981863
chr15:38646839-38646840(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
SPRED1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: SPRED1

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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