Detail Information

Basic Information:


  VIRBase ID:  

HHID00053964

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           RNF38:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p RNF38
miRBase
Accession/Entrez ID		 MIMAT0000461 152006
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RNF38
chr9:36365503(-) A-I      intronic
chr9:36369297(-) A-I      intronic
chr9:36362255(-) A-I      intronic
chr9:36378446(-) A-I      intronic
chr9:36372940(-) A-I      intronic
chr9:36369322(-) A-I      intronic
chr9:36369327(-) A-I      intronic
chr9:36369382(-) A-I      intronic
chr9:36369422(-) A-I      intronic
chr9:36369478(-) A-I      intronic
chr9:36372928(-) A-I      intronic
chr9:36378394(-) A-I      intronic
chr9:36378383(-) A-I      intronic
chr9:36371576(-) A-I      intronic
chr9:36370810(-) A-I      intronic
chr9:36346300(-) A-I      intronic
chr9:36362308(-) A-I      intronic
chr9:36346279(-) A-I      intronic
chr9:36346275(-) A-I      intronic
chr9:36369486(-) A-I      intronic
chr9:36350018(-) A-I      intronic
chr9:36347961(-) A-I      intronic
chr9:36394031(-) A-I      intronic
chr9:36394029(-) A-I      intronic
chr9:36383318(-) A-I      intronic
chr9:36350042(-) A-I      intronic
chr9:36378445(-) A-I      intronic
chr9:36346947(-) A-I      intronic
chr9:36346392(-) A-I      intronic
chr9:36346384(-) A-I      intronic
chr9:36369456(-) A-I      intronic
chr9:36361051(-) A-I      intronic
chr9:36361040(-) A-I      intronic
chr9:36361029(-) A-I      intronic
chr9:36346343(-) A-I      intronic
chr9:36341686(-) A-I      intronic
chr9:36362759(-) A-I      intronic
chr9:36361020(-) A-I      intronic
chr9:36349954(-) A-I      intronic
chr9:36365437(-) A-I      intronic
chr9:36346406(-) A-I      intronic
chr9:36346363(-) A-I      intronic
chr9:36362231(-) A-I      intronic
chr9:36362188(-) A-I      intronic
chr9:36362097(-) A-I      intronic
chr9:36361363(-) A-I      intronic
chr9:36362763(-) A-I      intronic
chr9:36361241(-) A-I      intronic
chr9:36358925(-) A-I      intronic
chr9:36365320(-) A-I      intronic
chr9:36365361(-) A-I      intronic
chr9:36362268(-) A-I      intronic
chr9:36365441(-) A-I      intronic
chr9:36349910(-) A-I      intronic
chr9:36339244(-) A-I      3'UTR
chr9:36367863(-) A-I      intronic
chr9:36346391(-) A-I      intronic
chr9:36397248(-) A-I      intronic
chr9:36347079(-) A-I      intronic
chr9:36350057(-) A-I      intronic
chr9:36362272(-) A-I      intronic
chr9:36370747(-) A-I      intronic
chr9:36371581(-) A-I      intronic
chr9:36346911(-) A-I      intronic
chr9:36370757(-) A-I      intronic
chr9:36365526(-) A-I      intronic
chr9:36349860(-) A-I      intronic
chr9:36348464(-) A-I      intronic
chr9:36359900(-) A-I      intronic
chr9:36365693(-) A-I      intronic
chr9:36365381(-) A-I      intronic
chr9:36362094(-) A-I      intronic
chr9:36358969(-) A-I      intronic
chr9:36365841(-) A-I      intronic
chr9:36350065(-) A-I      intronic
chr9:36362191(-) A-I      intronic
chr9:36363939(-) A-I      intronic
chr9:36341639(-) A-I      intronic
chr9:36397249(-) A-I      intronic
chr9:36346477(-) A-I      intronic
chr9:36363209(-) A-I      intronic
chr9:36370737(-) A-I      intronic
chr9:36350019(-) A-I      intronic
chr9:36346327(-) A-I      intronic
chr9:36370854(-) A-I      intronic
chr9:36340501(-) A-I      intronic
chr9:36361281(-) A-I      intronic
chr9:36371607(-) A-I      intronic
chr9:36346311(-) A-I      intronic
chr9:36346952(-) A-I      intronic
chr9:36346313(-) A-I      intronic
chr9:36374656(-) A-I      intronic
chr9:36346461(-) A-I      intronic
chr9:36346271(-) A-I      intronic
chr9:36350066(-) A-I      intronic
chr9:36349980(-) A-I      intronic
chr9:36361234(-) A-I      intronic
chr9:36362769(-) A-I      intronic
chr9:36373191(-) A-I      intronic
chr9:36346880(-) A-I      intronic
chr9:36350087(-) A-I      intronic
chr9:36365367(-) A-I      intronic
chr9:36348456(-) A-I      intronic
chr9:36361287(-) A-I      intronic
chr9:36345152(-) A-I      intronic
chr9:36370905(-) A-I      intronic
chr9:36362197(-) A-I      intronic
chr9:36346935(-) A-I      intronic
chr9:36365483(-) A-I      intronic
chr9:36365842(-) A-I      intronic
chr9:36346438(-) A-I      intronic
chr9:36346274(-) A-I      intronic
chr9:36370646(-) A-I      intronic
chr9:36346407(-) A-I      intronic
chr9:36349948(-) A-I      intronic
chr9:36350056(-) A-I      intronic
chr9:36358956(-) A-I      intronic
chr9:36365482(-) A-I      intronic
chr9:36347054(-) A-I      intronic
chr9:36347017(-) A-I      intronic
chr9:36365384(-) A-I      intronic
chr9:36374647(-) A-I      intronic
chr9:36346299(-) A-I      intronic
chr9:36347964(-) A-I      intronic
chr9:36349953(-) A-I      intronic
chr9:36378338(-) A-I      intronic
chr9:36371608(-) A-I      intronic
chr9:36374669(-) A-I      intronic
chr9:36362771(-) A-I      intronic
chr9:36365565(-) A-I      intronic
chr9:36349944(-) A-I      intronic
chr9:36373121(-) A-I      intronic
chr9:36370652(-) A-I      intronic
chr9:36347009(-) A-I      intronic
chr9:36361432(-) A-I      intronic
chr9:36365307(-) A-I      intronic
chr9:36365496(-) A-I      intronic
chr9:36371590(-) A-I      intronic
chr9:36370846(-) A-I      intronic
chr9:36346439(-) A-I      intronic
chr9:36380500(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RNF38
chr9:36346949(-) A-I intron -    22327324
chr9:36346274(-) A-G intron -    22484847
chr9:36346299(-) A-G intron -    22484847
chr9:36346313(-) A-G intron -    22484847
chr9:36346407(-) A-G intron -    22484847
chr9:36346438(-) A-G intron -    22484847
chr9:36346439(-) A-G intron -    22484847
chr9:36346477(-) A-G intron -    22484847
chr9:36346880(-) A-G intron -    22484847
chr9:36346912(-) A-G intron -    22484847
chr9:36346949(-) A-G intron -    22484847
chr9:36347884(-) A-G intron -    22484847
chr9:36349860(-) A-G intron -    22484847
chr9:36350019(-) A-G intron -    22484847
chr9:36350057(-) A-G intron -    22484847
chr9:36350087(-) A-G intron -    22484847
chr9:36365565(-) A-G intron -    22484847
chr9:36365681(-) C-A intron -    22484847
chr9:36371581(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RNF38
chr9:36339631-36339632(-) m6A 3'UTR       24981863
chr9:36339680-36339681(-) m6A 3'UTR       24981863
chr9:36339692-36339693(-) m6A 3'UTR       24981863
chr9:36353286-36353287(-) m6A CDS       27773535
chr9:36353298-36353299(-) m6A CDS       27773535
chr9:36356316-36356317(-) m6A CDS       27773535
chr9:36357804-36357805(-) m6A CDS//exon       27773535
chr9:36357926-36357927(-) m6A CDS//exon       27773535
chr9:36369857-36369858(-) m6A CDS//exon       27773535//27371828
chr9:36372552-36372553(-) m6A CDS//intron       27371828
chr9:36376097-36376098(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr9:36390506-36390507(-) m6A 5'UTR//CDS//exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
RNF38
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: RNF38

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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