Detail Information

Basic Information:


  VIRBase ID:  

HHID00053908

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           ZBTB10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p ZBTB10
miRBase
Accession/Entrez ID		 MIMAT0000461 65986
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RINZF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZBTB10
chr8:81424897(+) A-I      intronic
chr8:81424804(+) A-I      intronic
chr8:81404853(+) A-I      intronic
chr8:81404843(+) A-I      intronic
chr8:81424850(+) A-I      intronic
chr8:81404832(+) A-I      intronic
chr8:81425451(+) A-I      intronic
chr8:81405263(+) A-I      intronic
chr8:81425420(+) A-I      intronic
chr8:81424786(+) A-I      intronic
chr8:81420025(+) A-I      intronic
chr8:81413379(+) A-I      intronic
chr8:81405797(+) A-I      intronic
chr8:81405302(+) A-I      intronic
chr8:81405297(+) A-I      intronic
chr8:81405293(+) A-I      intronic
chr8:81405272(+) A-I      intronic
chr8:81425446(+) A-I      intronic
chr8:81420036(+) A-I      intronic
chr8:81405301(+) A-I      intronic
chr8:81419771(+) A-I      intronic
chr8:81405329(+) A-I      intronic
chr8:81413182(+) A-I      intronic
chr8:81404986(+) A-I      intronic
chr8:81405412(+) A-I      intronic
chr8:81413156(+) A-I      intronic
chr8:81419770(+) A-I      intronic
chr8:81413362(+) A-I      intronic
chr8:81419799(+) A-I      intronic
chr8:81402604(+) A-I      intronic
chr8:81413139(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZBTB10
chr8:81405301(+) A-G intron -    22484847
chr8:81405329(+) A-G intron -    22484847
chr8:81405412(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZBTB10
chr8:81397972-81397973(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:81398074-81398075(+) m6A 5'UTR//CDS       24284625//24209618//25456834//27371828//22608085
chr8:81398600-81398601(+) m6A 5'UTR//intron       22608085
chr8:81398870-81398871(+) m6A 5'UTR//intron       25456834//27371828//27773536//22608085
chr8:81398929-81398930(+) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22608085
chr8:81398955-81398956(+) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22608085
chr8:81399064-81399065(+) m6A CDS//intron       24209618//25456834//24981863//22608085
chr8:81399127-81399128(+) m6A CDS//intron       24209618//25456834//24981863//22608085
chr8:81399179-81399180(+) m6A CDS//intron       24209618//25456834//24981863//22608085
chr8:81399271-81399272(+) m6A CDS//intron       24209618//25456834//24981863//22608085
chr8:81399400-81399401(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr8:81399408-81399409(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr8:81399477-81399478(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr8:81399732-81399733(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr8:81399798-81399799(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399814-81399815(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399876-81399877(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399901-81399902(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399939-81399940(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399957-81399958(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81399995-81399996(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr8:81411786-81411787(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81411823-81411824(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81411894-81411895(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81411926-81411927(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81411945-81411946(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81411966-81411967(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412020-81412021(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr8:81412115-81412116(+) m6A CDS       24284625//24981863//26404942//22608085
chr8:81412188-81412189(+) m6A CDS       24284625//24981863//22608085
chr8:81412204-81412205(+) m6A CDS       24284625//24981863//27773535//22608085
chr8:81412344-81412345(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412418-81412419(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412466-81412467(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412475-81412476(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412488-81412489(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412493-81412494(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:81412612-81412613(+) m6A CDS       24981863//22608085
chr8:81430794-81430795(+) m6A CDS       24284625//27773535//22608085
chr8:81430801-81430802(+) m6A CDS       24284625//27773535//22608085
chr8:81431037-81431038(+) m6A CDS       24284625//27773535//22608085
chr8:81431084-81431085(+) m6A CDS       24284625//24981863//27773535//22608085
chr8:81431149-81431150(+) m6A CDS       24284625//24981863//27773535//22608085
chr8:81431167-81431168(+) m6A CDS       24284625//24981863//27773535//22608085
chr8:81431179-81431180(+) m6A CDS       24284625//24981863//27773535//22608085
chr8:81431534-81431535(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr8:81431566-81431567(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr8:81431615-81431616(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr8:81431799-81431800(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:81431831-81431832(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:81431887-81431888(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr8:81431941-81431942(+) m6A 3'UTR       24284625//24981863//22608085
chr8:81431953-81431954(+) m6A 3'UTR       24284625//24981863//22608085
chr8:81432317-81432318(+) m6A 3'UTR       24981863//22608085
chr8:81432381-81432382(+) m6A 3'UTR       24981863//22608085
chr8:81432407-81432408(+) m6A 3'UTR       24981863//22608085
chr8:81434933-81434934(+) m6A 3'UTR       27773535
chr8:81434990-81434991(+) m6A 3'UTR       27773535//22608085
chr8:81435059-81435060(+) m6A 3'UTR       24981863//27773535//22608085
chr8:81435172-81435173(+) m6A 3'UTR       22608085
chr8:81436191-81436192(+) m6A 3'UTR       27773535
chr8:81436203-81436204(+) m6A 3'UTR       27773535
chr8:81436212-81436213(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
ZBTB10
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: ZBTB10

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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