Basic Information:

  VIRBase ID:  

HHID00053888

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          MIB1:  NM_020774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	MIB1
miRBase Accession/Entrez ID	MIMAT0000461	57534
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIP-1//DIP1//LVNC7//MIB//ZZANK2//ZZZ6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIB1	chr18:19330943(+) A-I      intronic chr18:19330948(+) A-I      intronic chr18:19330957(+) A-I      intronic chr18:19330972(+) A-I      intronic chr18:19330993(+) A-I      intronic chr18:19387270(+) A-I      intronic chr18:19387282(+) A-I      intronic chr18:19385964(+) A-I      intronic chr18:19387313(+) A-I      intronic chr18:19394429(+) A-I      intronic chr18:19440889(+) A-I      intronic chr18:19440945(+) A-I      intronic chr18:19419569(+) A-I      intronic chr18:19387289(+) A-I      intronic chr18:19331008(+) A-I      intronic chr18:19330982(+) A-I      intronic chr18:19330981(+) A-I      intronic chr18:19330925(+) A-I      intronic chr18:19330351(+) A-I      intronic chr18:19329846(+) A-I      intronic chr18:19329701(+) A-I      intronic chr18:19441975(+) A-I      intronic chr18:19441930(+) A-I      intronic chr18:19441927(+) A-I      intronic chr18:19440942(+) A-I      intronic chr18:19440926(+) A-I      intronic chr18:19439756(+) A-I      intronic chr18:19439707(+) A-I      intronic chr18:19439703(+) A-I      intronic chr18:19439689(+) A-I      intronic chr18:19439685(+) A-I      intronic chr18:19439674(+) A-I      intronic chr18:19421959(+) A-I      intronic chr18:19421958(+) A-I      intronic chr18:19421256(+) A-I      intronic chr18:19421253(+) A-I      intronic chr18:19421221(+) A-I      intronic chr18:19419919(+) A-I      intronic chr18:19419596(+) A-I      intronic chr18:19419585(+) A-I      intronic chr18:19419530(+) A-I      intronic chr18:19419527(+) A-I      intronic chr18:19416209(+) A-I      intronic chr18:19416208(+) A-I      intronic chr18:19416201(+) A-I      intronic chr18:19416199(+) A-I      intronic chr18:19416198(+) A-I      intronic chr18:19416150(+) A-I      intronic chr18:19399262(+) A-I      intronic chr18:19399261(+) A-I      intronic chr18:19399183(+) A-I      intronic chr18:19399099(+) A-I      intronic chr18:19398802(+) A-I      intronic chr18:19398625(+) A-I      intronic chr18:19398515(+) A-I      intronic chr18:19394464(+) A-I      intronic chr18:19387272(+) A-I      intronic chr18:19387239(+) A-I      intronic chr18:19387236(+) A-I      intronic chr18:19387231(+) A-I      intronic chr18:19387227(+) A-I      intronic chr18:19387191(+) A-I      intronic chr18:19331358(+) A-I      intronic chr18:19387142(+) A-I      intronic chr18:19387136(+) A-I      intronic chr18:19386751(+) A-I      intronic chr18:19386262(+) A-I      intronic chr18:19386261(+) A-I      intronic chr18:19369592(+) A-I      intronic chr18:19369591(+) A-I      intronic chr18:19357728(+) A-I      intronic chr18:19357358(+) A-I      intronic chr18:19357274(+) A-I      intronic chr18:19357259(+) A-I      intronic chr18:19356903(+) A-I      intronic chr18:19356888(+) A-I      intronic chr18:19356883(+) A-I      intronic chr18:19356779(+) A-I      intronic chr18:19355996(+) A-I      intronic chr18:19421231(+) A-I      intronic chr18:19355994(+) A-I      intronic chr18:19355439(+) A-I      intronic chr18:19355438(+) A-I      intronic chr18:19355389(+) A-I      intronic chr18:19355342(+) A-I      intronic chr18:19355306(+) A-I      intronic chr18:19355275(+) A-I      intronic chr18:19355245(+) A-I      intronic chr18:19355167(+) A-I      intronic chr18:19355149(+) A-I      intronic chr18:19354545(+) A-I      intronic chr18:19354507(+) A-I      intronic chr18:19354498(+) A-I      intronic chr18:19354364(+) A-I      intronic chr18:19343937(+) A-I      intronic chr18:19337669(+) A-I      intronic chr18:19337668(+) A-I      intronic chr18:19337644(+) A-I      intronic chr18:19336645(+) A-I      intronic chr18:19333660(+) A-I      intronic chr18:19331419(+) A-I      intronic chr18:19331405(+) A-I      intronic chr18:19331118(+) A-I      intronic chr18:19331069(+) A-I      intronic chr18:19331044(+) A-I      intronic chr18:19440879(+) A-I      intronic chr18:19398643(+) A-I      intronic chr18:19399209(+) A-I      intronic chr18:19356827(+) A-I      intronic chr18:19355088(+) A-I      intronic chr18:19337260(+) A-I      intronic chr18:19439594(+) A-I      intronic chr18:19354429(+) A-I      intronic chr18:19440336(+) A-I      intronic chr18:19331407(+) A-I      intronic chr18:19419698(+) A-I      intronic chr18:19331409(+) A-I      intronic chr18:19399049(+) A-I      intronic chr18:19357655(+) A-I      intronic chr18:19387213(+) A-I      intronic chr18:19399200(+) A-I      intronic chr18:19328581(+) A-I      intronic chr18:19387230(+) A-I      intronic chr18:19385074(+) A-I      intronic chr18:19357538(+) A-I      intronic chr18:19387190(+) A-I      intronic chr18:19357266(+) A-I      intronic chr18:19355319(+) A-I      intronic chr18:19331048(+) A-I      intronic chr18:19441906(+) A-I      intronic chr18:19439770(+) A-I      intronic chr18:19337212(+) A-I      intronic chr18:19416104(+) A-I      intronic chr18:19357699(+) A-I      intronic chr18:19355405(+) A-I      intronic chr18:19386726(+) A-I      intronic chr18:19357616(+) A-I      intronic chr18:19398566(+) A-I      intronic chr18:19387234(+) A-I      intronic chr18:19440245(+) A-I      intronic chr18:19399198(+) A-I      intronic chr18:19331038(+) A-I      intronic chr18:19356243(+) A-I      intronic chr18:19386347(+) A-I      intronic chr18:19355313(+) A-I      intronic chr18:19441989(+) A-I      intronic chr18:19330933(+) A-I      intronic chr18:19357306(+) A-I      intronic chr18:19416270(+) A-I      intronic chr18:19386117(+) A-I      intronic chr18:19355113(+) A-I      intronic chr18:19394615(+) A-I      intronic chr18:19357202(+) A-I      intronic chr18:19354532(+) A-I      intronic chr18:19330903(+) A-I      intronic chr18:19394604(+) A-I      intronic chr18:19386640(+) A-I      intronic chr18:19394421(+) A-I      intronic chr18:19394680(+) A-I      intronic chr18:19386781(+) A-I      intronic chr18:19421248(+) A-I      intronic chr18:19354294(+) A-I      intronic chr18:19354512(+) A-I      intronic chr18:19357194(+) A-I      intronic chr18:19354434(+) A-I      intronic chr18:19398817(+) A-I      intronic chr18:19357233(+) A-I      intronic chr18:19387193(+) A-I      intronic chr18:19330884(+) A-I      intronic chr18:19398776(+) A-I      intronic chr18:19337661(+) A-I      intronic chr18:19330699(+) A-I      intronic chr18:19330487(+) A-I      intronic chr18:19394447(+) A-I      intronic chr18:19336555(+) A-I      intronic chr18:19398781(+) A-I      intronic chr18:19419589(+) A-I      intronic chr18:19355966(+) A-I      intronic chr18:19398555(+) A-I      intronic chr18:19361492(+) A-I      intronic chr18:19357596(+) A-I      intronic chr18:19440975(+) A-I      intronic chr18:19440906(+) A-I      intronic chr18:19355383(+) A-I      intronic chr18:19331348(+) A-I      intronic chr18:19441963(+) A-I      intronic chr18:19355973(+) A-I      intronic chr18:19337236(+) A-I      intronic chr18:19387137(+) A-I      intronic chr18:19354385(+) A-I      intronic chr18:19399132(+) A-I      intronic chr18:19329626(+) A-I      intronic chr18:19440126(+) A-I      intronic chr18:19337667(+) A-I      intronic chr18:19394469(+) A-I      intronic chr18:19443846(+) A-I      intronic chr18:19387318(+) A-I      intronic chr18:19398564(+) A-I      intronic chr18:19386766(+) A-I      intronic chr18:19330589(+) A-I      intronic chr18:19439242(+) A-I      intronic chr18:19357634(+) A-I      intronic chr18:19354366(+) A-I      intronic chr18:19387389(+) A-I      intronic chr18:19386789(+) A-I      intronic chr18:19386856(+) A-I      intronic chr18:19329702(+) A-I      intronic chr18:19386383(+) A-I      intronic chr18:19419497(+) A-I      intronic chr18:19394527(+) A-I      intronic chr18:19441966(+) A-I      intronic chr18:19419519(+) A-I      intronic chr18:19419684(+) A-I      intronic chr18:19394477(+) A-I      intronic chr18:19357293(+) A-I      intronic chr18:19330902(+) A-I      intronic chr18:19421982(+) A-I      intronic chr18:19354388(+) A-I      intronic chr18:19330919(+) A-I      intronic chr18:19357615(+) A-I      intronic chr18:19346761(+) A-I      intronic chr18:19354398(+) A-I      intronic chr18:19419559(+) A-I      intronic chr18:19395210(+) A-I      intronic chr18:19337709(+) A-I      intronic chr18:19350009(+) A-I      intronic chr18:19337254(+) A-I      intronic chr18:19394405(+) A-I      intronic chr18:19331340(+) A-I      intronic chr18:19355465(+) A-I      intronic chr18:19355334(+) A-I      intronic chr18:19443750(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MIB1	chr18:19405668(+) A-I intron -    16594986 chr18:19331012(+) A-G intron -    22484847 chr18:19336526(+) A-G intron -    22484847 chr18:19357716(+) A-G intron -    22484847 chr18:19361603(+) T-A intron -    22484847 chr18:19387318(+) A-G intron -    22484847 chr18:19421976(+) A-G intron -    22484847 chr18:19421982(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIB1	chr18:19321383-19321384(+) m6A 5'UTR//intron       24209618 chr18:19321611-19321612(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr18:19321701-19321702(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19321758-19321759(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19345749-19345750(+) m6A CDS//exon       22608085 chr18:19348666-19348667(+) m6A CDS//exon       24209618//24981863 chr18:19353600-19353601(+) m6A CDS//exon       24209618//24981863 chr18:19445264-19445265(+) m6A 3'UTR       24981863 chr18:19445311-19445312(+) m6A 3'UTR       24981863 chr18:19447867-19447868(+) m6A 3'UTR       24981863 chr18:19450245-19450246(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	MIB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: MIB1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).