Basic Information:

  VIRBase ID:  

HHID00053822

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          C16orf72:  NM_014117     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	C16orf72
miRBase Accession/Entrez ID	MIMAT0000461	29035
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRO0149//TAPR1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	C16orf72	chr16: 9200347     chr16: 9200359     chr16: 9200372     chr16: 9200385     chr16: 9200405     chr16: 9200033     chr16: 9200032     chr16: 9200008     chr16: 9200004     chr16: 9200002     chr16: 9200404     chr16: 9200046     chr16: 9200056     chr16: 9200067     chr16: 9200168     chr16: 9200170     chr16: 9200211     chr16: 9200236     chr16: 9200237     chr16: 9200254     chr16: 9200263     chr16: 9200266     chr16: 9200302     chr16: 9200311     chr16: 9200317     chr16: 9200334     chr16: 9200346

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C16orf72	chr16:9200334(+) A-I      intronic chr16:9206626(+) A-I      intronic chr16:9200263(+) A-I      intronic chr16:9200404(+) A-I      intronic chr16:9209500(+) A-I      intronic chr16:9200046(+) A-I      intronic chr16:9193303(+) A-I      intronic chr16:9193155(+) A-I      intronic chr16:9190624(+) A-I      intronic chr16:9197990(+) A-I      intronic chr16:9197992(+) A-I      intronic chr16:9193148(+) A-I      intronic chr16:9198107(+) A-I      intronic chr16:9198188(+) A-I      intronic chr16:9198207(+) A-I      intronic chr16:9200032(+) A-I      intronic chr16:9200033(+) A-I      intronic chr16:9200168(+) A-I      intronic chr16:9200211(+) A-I      intronic chr16:9200254(+) A-I      intronic chr16:9200004(+) A-I      intronic chr16:9215091(+) A-I      3'UTR chr16:9200008(+) A-I      intronic chr16:9200170(+) A-I      intronic chr16:9200266(+) A-I      intronic chr16:9200311(+) A-I      intronic chr16:9198070(+) A-I      intronic chr16:9198071(+) A-I      intronic chr16:9198100(+) A-I      intronic chr16:9200002(+) A-I      intronic chr16:9192068(+) A-I      intronic chr16:9200237(+) A-I      intronic chr16:9214904(+) A-I      3'UTR chr16:9200405(+) A-I      intronic chr16:9198110(+) A-I      intronic chr16:9195953(+) A-I      intronic chr16:9191228(+) A-I      intronic chr16:9200056(+) A-I      intronic chr16:9192069(+) A-I      intronic chr16:9209655(+) A-I      intronic chr16:9200236(+) A-I      intronic chr16:9209636(+) A-I      intronic chr16:9198058(+) A-I      intronic chr16:9200385(+) A-I      intronic chr16:9200317(+) A-I      intronic chr16:9198236(+) A-I      intronic chr16:9198222(+) A-I      intronic chr16:9200372(+) A-I      intronic chr16:9190625(+) A-I      intronic chr16:9200302(+) A-I      intronic chr16:9198231(+) A-I      intronic chr16:9200346(+) A-I      intronic chr16:9198194(+) A-I      intronic chr16:9200067(+) A-I      intronic chr16:9198221(+) A-I      intronic chr16:9198149(+) A-I      intronic chr16:9192096(+) A-I      intronic chr16:9200347(+) A-I      intronic chr16:9198169(+) A-I      intronic chr16:9200359(+) A-I      intronic chr16:9200654(+) A-I      intronic chr16:9201452(+) A-I      intronic chr16:9214994(+) A-I      3'UTR chr16:9214991(+) A-I      3'UTR chr16:9214946(+) A-I      3'UTR chr16:9214898(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C16orf72	chr16:9204662(+) A-I intron -    15342557 chr16:9204680(+) A-I intron -    15342557 chr16:9204685(+) A-I intron -    15258596 chr16:9204705(+) A-I intron -    15258596 chr16:9204719(+) A-I intron -    15258596 chr16:9204748(+) A-I intron -    15342557   //15258596   //22327324 chr16:9204784(+) A-I intron -    15258596 chr16:9204788(+) A-I intron -    15342557   //15258596   //21960545 chr16:9204801(+) A-I intron -    15342557 chr16:9204827(+) A-I intron -    15342557   //15258596 chr16:9204836(+) A-I intron -    15342557 chr16:9204847(+) A-I intron -    15342557 chr16:9205304(+) A-I intron -    15342557 chr16:9198071(+) A-I intron -    22327324 chr16:9200347(+) A-I intron -    22327324 chr16:9204883(+) A-I intron -    22327324 chr16:9200405(+) A-I intron -    21960545 chr16:9204788(+) A-G intron -    21725310   //22484847 chr16:9198071(+) A-G intron -    22484847 chr16:9198100(+) A-G intron -    22484847 chr16:9198149(+) A-G intron -    22484847 chr16:9204705(+) A-G intron -    22484847 chr16:9204715(+) A-G intron -    22484847 chr16:9204744(+) A-G intron -    22484847 chr16:9204745(+) A-G intron -    22484847 chr16:9204748(+) A-G intron -    22484847 chr16:9204816(+) A-G intron -    22484847 chr16:9204827(+) A-G intron -    22484847 chr16:9204847(+) A-G intron -    22484847 chr16:9204883(+) A-G intron -    22484847 chr16:9204886(+) A-G intron -    22484847 chr16:9204898(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C16orf72	chr16:9185609-9185610(+) m6A 5'UTR       24209618//24981863//22575960 chr16:9185999-9186000(+) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960 chr16:9186094-9186095(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr16:9186799-9186800(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:9196941-9196942(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9196999-9197000(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9197018-9197019(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9197058-9197059(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9197076-9197077(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9197130-9197131(+) m6A 3'UTR//intron       - chr16:9197170-9197171(+) m6A 3'UTR//intron       - chr16:9197227-9197228(+) m6A 3'UTR//intron       - chr16:9199654-9199655(+) m6A 3'UTR//intron       - chr16:9199709-9199710(+) m6A 3'UTR//intron       - chr16:9199747-9199748(+) m6A 3'UTR//intron       - chr16:9202582-9202583(+) Tm 3'UTR//intron       - chr16:9204054-9204055(+) m6A 3'UTR//intron       24981863 chr16:9204065-9204066(+) m6A 3'UTR//intron       24981863 chr16:9204695-9204696(+) m6A 3'UTR//intron       24981863 chr16:9204718-9204719(+) m6A 3'UTR//intron       24981863 chr16:9204815-9204816(+) m6A 3'UTR//intron       24981863 chr16:9204885-9204886(+) m6A 3'UTR//intron       24981863 chr16:9204900-9204901(+) m6A 3'UTR//intron       24981863 chr16:9204905-9204906(+) m6A 3'UTR//intron       24981863 chr16:9204911-9204912(+) m6A 3'UTR//intron       24981863 chr16:9205408-9205409(+) m6A 3'UTR//intron       24284625 chr16:9205448-9205449(+) m6A 3'UTR//intron       24284625 chr16:9205470-9205471(+) m6A 3'UTR//intron       24284625 chr16:9206370-9206371(+) m6A 3'UTR//intron       24284625 chr16:9206406-9206407(+) m6A 3'UTR//intron       24284625 chr16:9206482-9206483(+) m6A 3'UTR//intron       24284625 chr16:9206510-9206511(+) m6A 3'UTR//intron       22608085 chr16:9206538-9206539(+) m6A 3'UTR//intron       22608085 chr16:9206597-9206598(+) m6A 3'UTR//intron       22608085 chr16:9206650-9206651(+) m6A 3'UTR//intron       22608085 chr16:9206676-9206677(+) m6A 3'UTR//intron       24981863//22608085 chr16:9206700-9206701(+) m6A 3'UTR//intron       24981863 chr16:9206710-9206711(+) m6A 3'UTR//intron       24981863 chr16:9206743-9206744(+) m6A 3'UTR//intron       24981863 chr16:9210624-9210625(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210644-9210645(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210680-9210681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210691-9210692(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210734-9210735(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210769-9210770(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210776-9210777(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:9210845-9210846(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr16:9210879-9210880(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr16:9210963-9210964(+) m6A 3'UTR       - chr16:9210982-9210983(+) m6A 3'UTR       - chr16:9211025-9211026(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	C16orf72	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: C16orf72

Evidence Support:

Weak-Evidence	HITS-CLIP//PAR-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).