Detail Information

Basic Information:


  VIRBase ID:  

HHID00053769

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           ENPP4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p ENPP4
miRBase
Accession/Entrez ID		 MIMAT0000461 22875
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NPP4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ENPP4
chr6:46107289-46107290(+) m6A 5'UTR       22608085
chr6:46107352-46107353(+) m6A CDS       24981863//22608085
chr6:46107447-46107448(+) m6A CDS       24981863//22608085
chr6:46107527-46107528(+) m6A CDS       24981863//22608085
chr6:46107537-46107538(+) m6A CDS       24981863//22608085
chr6:46107619-46107620(+) m6A CDS       24981863//22608085
chr6:46107702-46107703(+) m6A CDS       24209618//24981863//22608085
chr6:46107808-46107809(+) m6A CDS       24209618//24981863//22608085
chr6:46107834-46107835(+) m6A CDS       24209618//24981863//22608085
chr6:46107843-46107844(+) m6A CDS       24209618//24981863//22608085
chr6:46107880-46107881(+) m6A CDS       24209618//24981863//22608085
chr6:46107907-46107908(+) m6A CDS       24209618//24981863//22608085
chr6:46107924-46107925(+) m6A CDS       24209618//24981863//22608085
chr6:46107979-46107980(+) m6A CDS       24209618//24981863//22608085
chr6:46108056-46108057(+) m6A CDS       24209618//24981863//22608085
chr6:46108068-46108069(+) m6A CDS       24209618//24981863//22608085
chr6:46108793-46108794(+) m6A CDS       24209618//24981863//22608085
chr6:46108810-46108811(+) m6A CDS       24981863//22608085
chr6:46108818-46108819(+) m6A CDS       24981863//22608085
chr6:46108854-46108855(+) m6A CDS       24981863//22608085
chr6:46108928-46108929(+) m6A CDS       24981863//22608085
chr6:46111073-46111074(+) m6A CDS       24209618//24981863//22608085
chr6:46111157-46111158(+) m6A CDS       24981863//22608085
chr6:46111176-46111177(+) m6A CDS       24981863//22608085
chr6:46111307-46111308(+) m6A CDS       24209618//24981863//22608085
chr6:46111420-46111421(+) m6A 3'UTR       24981863//22608085
chr6:46111476-46111477(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
ENPP4
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: ENPP4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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