Detail Information

Basic Information:


  VIRBase ID:  

HHID00053739

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           VPS26C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p VPS26C
miRBase
Accession/Entrez ID		 MIMAT0000461 10311
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DCRA//DSCR3//DSCRA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VPS26C
chr21:38596709(-) A-I      3'UTR
chr21:38602418(-) A-I      intronic
chr21:38614028(-) A-I      intronic
chr21:38613931(-) A-I      intronic
chr21:38596714(-) A-I      3'UTR
chr21:38596748(-) A-I      3'UTR
chr21:38596747(-) A-I      3'UTR
chr21:38614040(-) A-I      intronic
chr21:38602440(-) A-I      intronic
chr21:38614037(-) A-I      intronic
chr21:38601076(-) A-I      intronic
chr21:38620269(-) A-I      intronic
chr21:38629364(-) A-I      intronic
chr21:38629376(-) A-I      intronic
chr21:38629381(-) A-I      intronic
chr21:38629389(-) A-I      intronic
chr21:38632761(-) A-I      intronic
chr21:38632762(-) A-I      intronic
chr21:38620219(-) A-I      intronic
chr21:38620221(-) A-I      intronic
chr21:38620253(-) A-I      intronic
chr21:38600413(-) A-I      intronic
chr21:38601111(-) A-I      intronic
chr21:38602219(-) A-I      intronic
chr21:38602276(-) A-I      intronic
chr21:38602277(-) A-I      intronic
chr21:38602278(-) A-I      intronic
chr21:38602283(-) A-I      intronic
chr21:38602293(-) A-I      intronic
chr21:38602300(-) A-I      intronic
chr21:38602349(-) A-I      intronic
chr21:38602351(-) A-I      intronic
chr21:38602364(-) A-I      intronic
chr21:38602386(-) A-I      intronic
chr21:38602411(-) A-I      intronic
chr21:38602414(-) A-I      intronic
chr21:38602441(-) A-I      intronic
chr21:38620289(-) A-I      intronic
chr21:38601186(-) A-I      intronic
chr21:38602405(-) A-I      intronic
chr21:38632778(-) A-I      intronic
chr21:38619116(-) A-I      intronic
chr21:38612698(-) A-I      intronic
chr21:38614047(-) A-I      intronic
chr21:38614001(-) A-I      intronic
chr21:38601145(-) A-I      intronic
chr21:38619335(-) A-I      intronic
chr21:38628340(-) A-I      intronic
chr21:38596590(-) A-I      3'UTR
chr21:38596661(-) A-I      3'UTR
chr21:38596589(-) A-I      3'UTR
chr21:38601221(-) A-I      intronic
chr21:38601212(-) A-I      intronic
chr21:38614011(-) A-I      intronic
chr21:38628410(-) A-I      intronic
chr21:38601287(-) A-I      intronic
chr21:38601116(-) A-I      intronic
chr21:38602400(-) A-I      intronic
chr21:38620209(-) A-I      intronic
chr21:38601251(-) A-I      intronic
chr21:38619278(-) A-I      intronic
chr21:38601210(-) A-I      intronic
chr21:38601315(-) A-I      intronic
chr21:38602401(-) A-I      intronic
chr21:38601167(-) A-I      intronic
chr21:38602454(-) A-I      intronic
chr21:38629234(-) A-I      intronic
chr21:38614023(-) A-I      intronic
chr21:38628261(-) A-I      intronic
chr21:38602371(-) A-I      intronic
chr21:38614082(-) A-I      intronic
chr21:38601128(-) A-I      intronic
chr21:38601115(-) A-I      intronic

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
VPS26C
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: VPS26C

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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