Detail Information

Basic Information:


  VIRBase ID:  

HHID00053708

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           COX5A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p COX5A
miRBase
Accession/Entrez ID		 MIMAT0000461 9377
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - COX//COX-VA//MC4DN20//VA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR COX5A
chr15:75227514(-) A-I      intronic
chr15:75227536(-) A-I      intronic
chr15:75218784(-) A-I      intronic
chr15:75219750(-) A-I      intronic
chr15:75218789(-) A-I      intronic
chr15:75219745(-) A-I      intronic
chr15:75219694(-) A-I      intronic
chr15:75218768(-) A-I      intronic
chr15:75227554(-) A-I      intronic
chr15:75223638(-) A-I      intronic
chr15:75223598(-) A-I      intronic
chr15:75214577(-) A-I      intronic
chr15:75216364(-) A-I      intronic
chr15:75216355(-) A-I      intronic
chr15:75213176(-) A-I      intronic
chr15:75213949(-) A-I      intronic
chr15:75213971(-) A-I      intronic
chr15:75214312(-) A-I      intronic
chr15:75214355(-) A-I      intronic
chr15:75214363(-) A-I      intronic
chr15:75214493(-) A-I      intronic
chr15:75224162(-) A-I      intronic
chr15:75215042(-) A-I      intronic
chr15:75215054(-) A-I      intronic
chr15:75215099(-) A-I      intronic
chr15:75215103(-) A-I      intronic
chr15:75223676(-) A-I      intronic
chr15:75223698(-) A-I      intronic
chr15:75224006(-) A-I      intronic
chr15:75224054(-) A-I      intronic
chr15:75215625(-) A-I      intronic
chr15:75215616(-) A-I      intronic
chr15:75224167(-) A-I      intronic
chr15:75225153(-) A-I      intronic
chr15:75216712(-) A-I      intronic
chr15:75225154(-) A-I      intronic
chr15:75225205(-) A-I      intronic
chr15:75225221(-) A-I      intronic
chr15:75226454(-) A-I      intronic
chr15:75226568(-) A-I      intronic
chr15:75226836(-) A-I      intronic
chr15:75226844(-) A-I      intronic
chr15:75226867(-) A-I      intronic
chr15:75227511(-) A-I      intronic
chr15:75227512(-) A-I      intronic
chr15:75227549(-) A-I      intronic
chr15:75227625(-) A-I      intronic
chr15:75227890(-) A-I      intronic
chr15:75219964(-) A-I      intronic
chr15:75215139(-) A-I      intronic
chr15:75215135(-) A-I      intronic
chr15:75219965(-) A-I      intronic
chr15:75220044(-) A-I      intronic
chr15:75224055(-) A-I      intronic
chr15:75220074(-) A-I      intronic
chr15:75222996(-) A-I      intronic
chr15:75223607(-) A-I      intronic
chr15:75219721(-) A-I      intronic
chr15:75219731(-) A-I      intronic
chr15:75216636(-) A-I      intronic
chr15:75216695(-) A-I      intronic
chr15:75219697(-) A-I      intronic
chr15:75219603(-) A-I      intronic
chr15:75217620(-) A-I      intronic
chr15:75217461(-) A-I      intronic
chr15:75219783(-) A-I      intronic
chr15:75223616(-) A-I      intronic
chr15:75223650(-) A-I      intronic
chr15:75216666(-) A-I      intronic
chr15:75216386(-) A-I      intronic
chr15:75223639(-) A-I      intronic
chr15:75213075(-) A-I      intronic
chr15:75218744(-) A-I      intronic
chr15:75217633(-) A-I      intronic
chr15:75213098(-) A-I      intronic
chr15:75216635(-) A-I      intronic
chr15:75218286(-) A-I      intronic
chr15:75227832(-) A-I      intronic
chr15:75228510(-) A-I      intronic
chr15:75214969(-) A-I      intronic
chr15:75220001(-) A-I      intronic
chr15:75214664(-) A-I      intronic
chr15:75217845(-) A-I      intronic
chr15:75217541(-) A-I      intronic
chr15:75225309(-) A-I      intronic
chr15:75223295(-) A-I      intronic
chr15:75216766(-) A-I      intronic
chr15:75216383(-) A-I      intronic
chr15:75220094(-) A-I      intronic
chr15:75219591(-) A-I      intronic
chr15:75213076(-) A-I      intronic
chr15:75225176(-) A-I      intronic
chr15:75225655(-) A-I      intronic
chr15:75217808(-) A-I      intronic
chr15:75214679(-) A-I      intronic
chr15:75213207(-) A-I      intronic
chr15:75228163(-) A-I      intronic
chr15:75217827(-) A-I      intronic
chr15:75219614(-) A-I      intronic
chr15:75213271(-) A-I      intronic
chr15:75216637(-) A-I      intronic
chr15:75213987(-) A-I      intronic
chr15:75223597(-) A-I      intronic
chr15:75215562(-) A-I      intronic
chr15:75219951(-) A-I      intronic
chr15:75214905(-) A-I      intronic
chr15:75220030(-) A-I      intronic
chr15:75216459(-) A-I      intronic
chr15:75216810(-) A-I      intronic
chr15:75214311(-) A-I      intronic
chr15:75228212(-) A-I      intronic
chr15:75220013(-) A-I      intronic
chr15:75226571(-) A-I      intronic
chr15:75222994(-) A-I      intronic
chr15:75220082(-) A-I      intronic
chr15:75216399(-) A-I      intronic
chr15:75216756(-) A-I      intronic
chr15:75213102(-) A-I      intronic
chr15:75214604(-) A-I      intronic
chr15:75215510(-) A-I      intronic
chr15:75219578(-) A-I      intronic
chr15:75222906(-) A-I      intronic
chr15:75215598(-) A-I      intronic
chr15:75226584(-) A-I      intronic
chr15:75213068(-) A-I      intronic
chr15:75215704(-) A-I      intronic
chr15:75227574(-) A-I      intronic
chr15:75214985(-) A-I      intronic
chr15:75215186(-) A-I      intronic
chr15:75214946(-) A-I      intronic
chr15:75219950(-) A-I      intronic
chr15:75222921(-) A-I      intronic
chr15:75215211(-) A-I      intronic
chr15:75225212(-) A-I      intronic
chr15:75213156(-) A-I      intronic
chr15:75214687(-) A-I      intronic
chr15:75214357(-) A-I      intronic
chr15:75214548(-) A-I      intronic
chr15:75215189(-) A-I      intronic
chr15:75215523(-) A-I      intronic
chr15:75214947(-) A-I      intronic
chr15:75222121(-) A-I      intronic
chr15:75218304(-) A-I      intronic
chr15:75213279(-) A-I      intronic
chr15:75223730(-) A-I      intronic
chr15:75227541(-) A-I      intronic
chr15:75215171(-) A-I      intronic
chr15:75214886(-) A-I      intronic
chr15:75219685(-) A-I      intronic
chr15:75217955(-) A-I      intronic
chr15:75214483(-) A-I      intronic
chr15:75228113(-) A-I      intronic
chr15:75215145(-) A-I      intronic
chr15:75223115(-) A-I      intronic
chr15:75213978(-) A-I      intronic
chr15:75225103(-) A-I      intronic
chr15:75215287(-) A-I      intronic
chr15:75213310(-) A-I      intronic
chr15:75223836(-) A-I      intronic
chr15:75217826(-) A-I      intronic
chr15:75215092(-) A-I      intronic
chr15:75215263(-) A-I      intronic
chr15:75218790(-) A-I      intronic
chr15:75214626(-) A-I      intronic
chr15:75213074(-) A-I      intronic
chr15:75215175(-) A-I      intronic
chr15:75215074(-) A-I      intronic
chr15:75215269(-) A-I      intronic
chr15:75225706(-) A-I      intronic
chr15:75225646(-) A-I      intronic
chr15:75215644(-) A-I      intronic
chr15:75227728(-) A-I      intronic
chr15:75228082(-) A-I      intronic
chr15:75224780(-) A-I      intronic
chr15:75227553(-) A-I      intronic
chr15:75218720(-) A-I      intronic
chr15:75217419(-) A-I      intronic
chr15:75223725(-) A-I      intronic
chr15:75217554(-) A-I      intronic
chr15:75225202(-) A-I      intronic
chr15:75214578(-) A-I      intronic
chr15:75220056(-) A-I      intronic
chr15:75225716(-) A-I      intronic
chr15:75217558(-) A-I      intronic
chr15:75222019(-) A-I      intronic
chr15:75225633(-) A-I      intronic
chr15:75213108(-) A-I      intronic
chr15:75214968(-) A-I      intronic
chr15:75215548(-) A-I      intronic
chr15:75227727(-) A-I      intronic
chr15:75214484(-) A-I      intronic
chr15:75225265(-) A-I      intronic
chr15:75224137(-) A-I      intronic
chr15:75220031(-) A-I      intronic
chr15:75219682(-) A-I      intronic
chr15:75223694(-) A-I      intronic
chr15:75215231(-) A-I      intronic
chr15:75215285(-) A-I      intronic
chr15:75229082(-) A-I      intronic
chr15:75227715(-) A-I      intronic
chr15:75222988(-) A-I      intronic
chr15:75215553(-) A-I      intronic
chr15:75218216(-) A-I      intronic
chr15:75213170(-) A-I      intronic
chr15:75215122(-) A-I      intronic
chr15:75217581(-) A-I      intronic
chr15:75225328(-) A-I      intronic
chr15:75213056(-) A-I      intronic
chr15:75213237(-) A-I      intronic
chr15:75217641(-) A-I      intronic
chr15:75215617(-) A-I      intronic
chr15:75214939(-) A-I      intronic
chr15:75227579(-) A-I      intronic
chr15:75213062(-) A-I      intronic
chr15:75214285(-) A-I      intronic
chr15:75214669(-) A-I      intronic
chr15:75215260(-) A-I      intronic
chr15:75215708(-) A-I      intronic
chr15:75218776(-) A-I      intronic
chr15:75215230(-) A-I      intronic
chr15:75216264(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED COX5A
chr15:75214311(-) A-G intron -    22484847
chr15:75217633(-) A-G intron -    22484847
chr15:75220030(-) A-G intron -    22484847
chr15:75220082(-) A-G intron -    22484847
chr15:75222994(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase COX5A
chr15:75216018-75216019(-) m6A CDS//intron       22575960
chr15:75216042-75216043(-) m6A CDS//intron       22575960
chr15:75216057-75216058(-) m6A CDS//intron       22575960
chr15:75216063-75216064(-) m6A CDS//intron       22575960
chr15:75216099-75216100(-) m6A CDS//intron       22575960
chr15:75230031-75230032(-) m6A 5'UTR//intron       27773535
chr15:75230090-75230091(-) m6A 5'UTR//intron       22575960
chr15:75230273-75230274(-) m6A CDS       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
COX5A
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: COX5A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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