Detail Information

Basic Information:


  VIRBase ID:  

HHID00053700

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           CPNE1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p CPNE1
miRBase
Accession/Entrez ID		 MIMAT0000461 8904
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - COPN1//CPN1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CPNE1
chr20:34248307(-) A-I      intronic
chr20:34248312(-) A-I      intronic
chr20:34227391(-) A-I      intronic
chr20:34217797(-) A-I      intronic
chr20:34217752(-) A-I      intronic
chr20:34217740(-) A-I      intronic
chr20:34218209(-) A-I      intronic
chr20:34214851(-) A-I      intronic
chr20:34234388(-) A-I      intronic
chr20:34234418(-) A-I      intronic
chr20:34235924(-) A-I      intronic
chr20:34214865(-) A-I      intronic
chr20:34217832(-) A-I      intronic
chr20:34217856(-) A-I      intronic
chr20:34217857(-) A-I      intronic
chr20:34218004(-) A-I      intronic
chr20:34217813(-) A-I      intronic
chr20:34221709(-) A-I      intronic
chr20:34222359(-) A-I      intronic
chr20:34222429(-) A-I      intronic
chr20:34222434(-) A-I      intronic
chr20:34214875(-) A-I      intronic
chr20:34214892(-) A-I      intronic
chr20:34214906(-) A-I      intronic
chr20:34214966(-) A-I      intronic
chr20:34214986(-) A-I      intronic
chr20:34214998(-) A-I      intronic
chr20:34215010(-) A-I      intronic
chr20:34215088(-) A-I      intronic
chr20:34215846(-) A-I      intronic
chr20:34217601(-) A-I      intronic
chr20:34217637(-) A-I      intronic
chr20:34217734(-) A-I      intronic
chr20:34234368(-) A-I      intronic
chr20:34227440(-) A-I      intronic
chr20:34227407(-) A-I      intronic
chr20:34227351(-) A-I      intronic
chr20:34227337(-) A-I      intronic
chr20:34222447(-) A-I      intronic
chr20:34217751(-) A-I      intronic
chr20:34218116(-) A-I      intronic
chr20:34234417(-) A-I      intronic
chr20:34222721(-) A-I      intronic
chr20:34215023(-) A-I      intronic
chr20:34218094(-) A-I      intronic
chr20:34234401(-) A-I      intronic
chr20:34218130(-) A-I      intronic
chr20:34222440(-) A-I      intronic
chr20:34218211(-) A-I      intronic
chr20:34221733(-) A-I      intronic
chr20:34217831(-) A-I      intronic
chr20:34217757(-) A-I      intronic
chr20:34217705(-) A-I      intronic
chr20:34244631(-) A-I      intronic
chr20:34222713(-) A-I      intronic
chr20:34248397(-) A-I      intronic
chr20:34217794(-) A-I      intronic
chr20:34227373(-) A-I      intronic
chr20:34231417(-) A-I      intronic
chr20:34215001(-) A-I      intronic
chr20:34227461(-) A-I      intronic
chr20:34235720(-) A-I      intronic
chr20:34215027(-) A-I      intronic
chr20:34217784(-) A-I      intronic
chr20:34217774(-) A-I      intronic
chr20:34222480(-) A-I      intronic
chr20:34222829(-) A-I      intronic
chr20:34217879(-) A-I      intronic
chr20:34217729(-) A-I      intronic
chr20:34248368(-) A-I      intronic
chr20:34227530(-) A-I      intronic
chr20:34227539(-) A-I      intronic
chr20:34218092(-) A-I      intronic
chr20:34215047(-) A-I      intronic
chr20:34222350(-) A-I      intronic
chr20:34218212(-) A-I      intronic
chr20:34222865(-) A-I      intronic
chr20:34218104(-) A-I      intronic
chr20:34217759(-) A-I      intronic
chr20:34222826(-) A-I      intronic
chr20:34235747(-) A-I      intronic
chr20:34214955(-) A-I      intronic
chr20:34222469(-) A-I      intronic
chr20:34214962(-) A-I      intronic
chr20:34217673(-) A-I      intronic
chr20:34217760(-) A-I      intronic
chr20:34217775(-) A-I      intronic
chr20:34218050(-) A-I      intronic
chr20:34248231(-) A-I      intronic
chr20:34217745(-) A-I      intronic
chr20:34227423(-) A-I      intronic
chr20:34227466(-) A-I      intronic
chr20:34248334(-) A-I      intronic
chr20:34218067(-) A-I      intronic
chr20:34217719(-) A-I      intronic
chr20:34222916(-) A-I      intronic
chr20:34217678(-) A-I      intronic
chr20:34244528(-) A-I      intronic
chr20:34221712(-) A-I      intronic
chr20:34217776(-) A-I      intronic
chr20:34227324(-) A-I      intronic
chr20:34217999(-) A-I      intronic
chr20:34222794(-) A-I      intronic
chr20:34246599(-) A-I      intronic
chr20:34235809(-) A-I      intronic
chr20:34218129(-) A-I      intronic
chr20:34217683(-) A-I      intronic
chr20:34222353(-) A-I      intronic
chr20:34217808(-) A-I      intronic
chr20:34217957(-) A-I      intronic
chr20:34235925(-) A-I      intronic
chr20:34217758(-) A-I      intronic
chr20:34235812(-) A-I      intronic
chr20:34233920(-) A-I      intronic
chr20:34234395(-) A-I      intronic
chr20:34244594(-) A-I      intronic
chr20:34234385(-) A-I      intronic
chr20:34217837(-) A-I      intronic
chr20:34217709(-) A-I      intronic
chr20:34246670(-) A-I      intronic
chr20:34227396(-) A-I      intronic
chr20:34215850(-) A-I      intronic
chr20:34222838(-) A-I      intronic
chr20:34218107(-) A-I      intronic
chr20:34222061(-) A-I      intronic
chr20:34217629(-) A-I      intronic
chr20:34218068(-) A-I      intronic
chr20:34227364(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CPNE1
chr20:34217719(-) A-I intron -    21960545   //22327324
chr20:34217745(-) A-I intron -    21960545   //22327324
chr20:34217758(-) A-I intron -    22327324
chr20:34217957(-) A-I intron -    21960545   //22327324
chr20:34218094(-) A-I intron -    21960545   //22327324
chr20:34218165(-) A-I intron -    21960545   //22327324
chr20:34218212(-) A-I intron -    21960545   //22327324
chr20:34222721(-) A-I intron -    22327324
chr20:34217683(-) A-I intron -    21960545
chr20:34217705(-) A-I intron -    21960545
chr20:34217879(-) A-I intron -    21960545
chr20:34217999(-) A-I intron -    21960545
chr20:34215027(-) A-G intron -    22484847
chr20:34217709(-) A-G intron -    22484847
chr20:34217719(-) A-G intron -    22484847
chr20:34217745(-) A-G intron -    22484847
chr20:34217749(-) A-G intron -    22484847
chr20:34217750(-) A-G intron -    22484847
chr20:34217758(-) A-G intron -    22484847
chr20:34217759(-) A-G intron -    22484847
chr20:34217775(-) A-G intron -    22484847
chr20:34217786(-) A-G intron -    22484847
chr20:34217831(-) A-G intron -    22484847
chr20:34217957(-) A-G intron -    22484847
chr20:34217999(-) A-G intron -    22484847
chr20:34218053(-) A-G intron -    22484847
chr20:34218067(-) A-G intron -    22484847
chr20:34218092(-) A-G intron -    22484847
chr20:34218094(-) A-G intron -    22484847
chr20:34218107(-) A-G intron -    22484847
chr20:34218108(-) A-G intron -    22484847
chr20:34218129(-) A-G intron -    22484847
chr20:34218130(-) A-G intron -    22484847
chr20:34218165(-) A-G intron -    22484847
chr20:34218212(-) A-G intron -    22484847
chr20:34222721(-) A-G intron -    22484847
chr20:34222746(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CPNE1
chr20:34213969-34213970(-) m6A 3'UTR//exon       27773535
chr20:34213979-34213980(-) m6A 3'UTR//exon       27773535
chr20:34214278-34214279(-) m6A 3'UTR//CDS//exon       27773535
chr20:34214353-34214354(-) m6A exon//intron       27773535
chr20:34214684-34214685(-) Cm 3'UTR//CDS//exon       -
chr20:34215209-34215210(-) m6A CDS//exon       27773535
chr20:34215391-34215392(-) m6A exon//intron       27773535
chr20:34218436-34218437(-) m6A exon//intron       27773535
chr20:34220441-34220442(-) m6A CDS//exon       26404942
chr20:34220502-34220503(-) m6A CDS//exon       26404942
chr20:34220783-34220784(-) m6A CDS//exon       24284625//24209618//27371828//22575960//22608085
chr20:34227971-34227972(-) Cm intron       -
chr20:34240025-34240026(-) m6A intron       24981863//22608085
chr20:34240097-34240098(-) m6A intron       25456834//24981863//26404942//22608085
chr20:34240186-34240187(-) m6A intron       24981863//26404942//22608085
chr20:34240198-34240199(-) m6A intron       24981863//26404942//22608085
chr20:34240231-34240232(-) m6A intron       26404942//22608085
chr20:34240268-34240269(-) m6A intron       22608085
chr20:34240294-34240295(-) Y intron       25219674
chr20:34240914-34240915(-) m6A intron       24981863//22608085
chr20:34240919-34240920(-) m6A intron       24981863//22608085
chr20:34240946-34240947(-) m6A intron       24284625//24981863//22608085
chr20:34240968-34240969(-) m6A intron       24284625//24981863//22608085
chr20:34241186-34241187(-) m6A intron       24284625//24981863//22608085
chr20:34241216-34241217(-) m6A intron       24284625//24981863//27773535//22608085
chr20:34241246-34241247(-) m6A intron       24284625//24981863//27773535//22608085
chr20:34241261-34241262(-) m6A intron       24284625//24981863//27773535//22608085
chr20:34241276-34241277(-) m6A intron       24284625//24981863//27773535//22608085
chr20:34241420-34241421(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:34241486-34241487(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr20:34241676-34241677(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34241684-34241685(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34241768-34241769(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34241849-34241850(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34241916-34241917(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr20:34242025-34242026(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr20:34242047-34242048(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr20:34242056-34242057(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr20:34242104-34242105(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr20:34242156-34242157(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34242378-34242379(-) m6A intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34242438-34242439(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:34242696-34242697(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:34242775-34242776(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:34242799-34242800(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:34242807-34242808(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:34242891-34242892(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:34242926-34242927(-) m6A intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:34242970-34242971(-) m6A intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr20:34242992-34242993(-) m6A intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr20:34243127-34243128(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:34243191-34243192(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:34243198-34243199(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:34252360-34252361(-) m6A 5'UTR//exon//intron       24284625//24981863
chr20:34252372-34252373(-) m6A 5'UTR//exon//intron       24284625
chr20:34252675-34252676(-) m6A exon//intron       24284625//24209618//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
CPNE1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|HeLa-S3 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: CPNE1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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