Basic Information:

  VIRBase ID:  

HHID00053688

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          OGT:  NM_181673     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	OGT
miRBase Accession/Entrez ID	MIMAT0000461	8473
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HINCUT-1//HRNT1//MRX106//O-GLCNAC//OGT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OGT	chrX:70784845(+) A-I      intronic chrX:70784848(+) A-I      intronic chrX:70790773(+) A-I      intronic chrX:70769095(+) A-I      intronic chrX:70771961(+) A-I      intronic chrX:70792363(+) A-I      intronic chrX:70791818(+) A-I      intronic chrX:70791786(+) A-I      intronic chrX:70790912(+) A-I      intronic chrX:70790857(+) A-I      intronic chrX:70790851(+) A-I      intronic chrX:70771951(+) A-I      intronic chrX:70771887(+) A-I      intronic chrX:70771965(+) A-I      intronic chrX:70771978(+) A-I      intronic chrX:70769096(+) A-I      intronic chrX:70769375(+) A-I      intronic chrX:70769493(+) A-I      intronic chrX:70771262(+) A-I      intronic chrX:70771320(+) A-I      intronic chrX:70771321(+) A-I      intronic chrX:70771322(+) A-I      intronic chrX:70771323(+) A-I      intronic chrX:70771439(+) A-I      intronic chrX:70790770(+) A-I      intronic chrX:70790675(+) A-I      intronic chrX:70790132(+) A-I      intronic chrX:70789991(+) A-I      intronic chrX:70789952(+) A-I      intronic chrX:70789947(+) A-I      intronic chrX:70789528(+) A-I      intronic chrX:70771993(+) A-I      intronic chrX:70772025(+) A-I      intronic chrX:70772262(+) A-I      intronic chrX:70772368(+) A-I      intronic chrX:70790783(+) A-I      intronic chrX:70772414(+) A-I      intronic chrX:70772496(+) A-I      intronic chrX:70784851(+) A-I      intronic chrX:70771803(+) A-I      intronic chrX:70792566(+) A-I      intronic chrX:70792542(+) A-I      intronic chrX:70784878(+) A-I      intronic chrX:70785095(+) A-I      intronic chrX:70785216(+) A-I      intronic chrX:70785255(+) A-I      intronic chrX:70785313(+) A-I      intronic chrX:70772497(+) A-I      intronic chrX:70779952(+) A-I      intronic chrX:70779964(+) A-I      intronic chrX:70785340(+) A-I      intronic chrX:70785342(+) A-I      intronic chrX:70788567(+) A-I      intronic chrX:70788571(+) A-I      intronic chrX:70788599(+) A-I      intronic chrX:70788610(+) A-I      intronic chrX:70788635(+) A-I      intronic chrX:70788902(+) A-I      intronic chrX:70788924(+) A-I      intronic chrX:70785314(+) A-I      intronic chrX:70785301(+) A-I      intronic chrX:70775357(+) A-I      intronic chrX:70775346(+) A-I      intronic chrX:70769489(+) A-I      intronic chrX:70769486(+) A-I      intronic chrX:70769454(+) A-I      intronic chrX:70769458(+) A-I      intronic chrX:70768953(+) A-I      intronic chrX:70772378(+) A-I      intronic chrX:70772404(+) A-I      intronic chrX:70768930(+) A-I      intronic chrX:70768886(+) A-I      intronic chrX:70792523(+) A-I      intronic chrX:70792466(+) A-I      intronic chrX:70792440(+) A-I      intronic chrX:70792429(+) A-I      intronic chrX:70792377(+) A-I      intronic chrX:70775381(+) A-I      intronic chrX:70779968(+) A-I      intronic chrX:70786948(+) A-I      intronic chrX:70792596(+) A-I      intronic chrX:70786945(+) A-I      intronic chrX:70786943(+) A-I      intronic chrX:70786934(+) A-I      intronic chrX:70786901(+) A-I      intronic chrX:70786899(+) A-I      intronic chrX:70786894(+) A-I      intronic chrX:70786890(+) A-I      intronic chrX:70786827(+) A-I      intronic chrX:70786806(+) A-I      intronic chrX:70785609(+) A-I      intronic chrX:70785606(+) A-I      intronic chrX:70785604(+) A-I      intronic chrX:70775322(+) A-I      intronic chrX:70785600(+) A-I      intronic chrX:70768893(+) A-I      intronic chrX:70768905(+) A-I      intronic chrX:70768955(+) A-I      intronic chrX:70785583(+) A-I      intronic chrX:70768973(+) A-I      intronic chrX:70775310(+) A-I      intronic chrX:70785550(+) A-I      intronic chrX:70785579(+) A-I      intronic chrX:70786942(+) A-I      intronic chrX:70768974(+) A-I      intronic chrX:70768992(+) A-I      intronic chrX:70769092(+) A-I      intronic chrX:70779972(+) A-I      intronic chrX:70780035(+) A-I      intronic chrX:70780073(+) A-I      intronic chrX:70780074(+) A-I      intronic chrX:70780829(+) A-I      intronic chrX:70780839(+) A-I      intronic chrX:70780852(+) A-I      intronic chrX:70780878(+) A-I      intronic chrX:70780958(+) A-I      intronic chrX:70781294(+) A-I      intronic chrX:70781298(+) A-I      intronic chrX:70788925(+) A-I      intronic chrX:70788933(+) A-I      intronic chrX:70789001(+) A-I      intronic chrX:70789012(+) A-I      intronic chrX:70789015(+) A-I      intronic chrX:70789057(+) A-I      intronic chrX:70789063(+) A-I      intronic chrX:70789067(+) A-I      intronic chrX:70784743(+) A-I      intronic chrX:70784751(+) A-I      intronic chrX:70771952(+) A-I      intronic chrX:70785261(+) A-I      intronic chrX:70784847(+) A-I      intronic chrX:70789392(+) A-I      intronic chrX:70784735(+) A-I      intronic chrX:70772503(+) A-I      intronic chrX:70789453(+) A-I      intronic chrX:70784913(+) A-I      intronic chrX:70785341(+) A-I      intronic chrX:70791759(+) A-I      intronic chrX:70785170(+) A-I      intronic chrX:70785347(+) A-I      intronic chrX:70784846(+) A-I      intronic chrX:70789686(+) A-I      intronic chrX:70785276(+) A-I      intronic chrX:70789084(+) A-I      intronic chrX:70788930(+) A-I      intronic chrX:70785194(+) A-I      intronic chrX:70771974(+) A-I      intronic chrX:70779877(+) A-I      intronic chrX:70771882(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OGT	chrX:70772332(+) A-I intron -    22327324 chrX:70772339(+) A-I intron -    22327324 chrX:70784846(+) A-I intron -    22327324 chrX:70784847(+) A-I intron -    22327324 chrX:70785170(+) A-I intron -    22327324 chrX:70785597(+) A-I intron -    22327324 chrX:70786802(+) A-I intron -    22327324 chrX:70786866(+) A-I intron -    22327324 chrX:70786889(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OGT	chrX:70752961-70752962(+) m6A 5'UTR//exon       24284625//24981863//22608085 chrX:70753109-70753110(+) m6A 5'UTR//exon       24284625//24981863//22575960 chrX:70764501-70764502(+) m6A exon//intron       22608085 chrX:70764511-70764512(+) m6A exon//intron       22608085 chrX:70764528-70764529(+) m6A exon//intron       24981863//22608085 chrX:70764579-70764580(+) m6A exon//intron       24981863//26404942//27773535//22608085 chrX:70764592-70764593(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764602-70764603(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764681-70764682(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764687-70764688(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764715-70764716(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764829-70764830(+) m6A exon//intron       24284625//24981863//26404942//22608085 chrX:70765029-70765030(+) m6A exon//intron       24284625 chrX:70767261-70767262(+) m6A exon//intron       26404942 chrX:70767290-70767291(+) m6A exon//intron       26404942 chrX:70767331-70767332(+) m6A exon//intron       26404942 chrX:70767345-70767346(+) m6A exon//intron       26404942 chrX:70767362-70767363(+) m6A exon//intron       26404942 chrX:70767401-70767402(+) m6A exon//intron       26404942 chrX:70783200-70783201(+) m6A CDS//exon       27773535 chrX:70783291-70783292(+) m6A CDS//exon       26404942 chrX:70783333-70783334(+) m6A CDS//exon       26404942 chrX:70783346-70783347(+) Cm CDS//exon       - chrX:70787666-70787667(+) m6A exon//intron       - chrX:70787847-70787848(+) m6A CDS//exon       24284625 chrX:70787914-70787915(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787932-70787933(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787952-70787953(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793532-70793533(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793547-70793548(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793598-70793599(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793650-70793651(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793705-70793706(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793789-70793790(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793815-70793816(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793831-70793832(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793838-70793839(+) Y 3'UTR//exon       26075521 chrX:70794133-70794134(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794153-70794154(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794188-70794189(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794392-70794393(+) Y 3'UTR//exon       26075521 chrX:70794821-70794822(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794865-70794866(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794899-70794900(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794917-70794918(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794987-70794988(+) m6A 3'UTR       24284625//26404942 chrX:70795176-70795177(+) m6A 3'UTR       26404942 chrX:70795244-70795245(+) m6A 3'UTR       24284625//26404942 chrX:70795265-70795266(+) m6A 3'UTR       24284625//26404942 chrX:70795380-70795381(+) m6A 3'UTR       24284625//26404942 chrX:70795500-70795501(+) m6A 3'UTR       24284625//26404942 chrX:70795588-70795589(+) m6A 3'UTR       24284625//27773535 chrX:70795624-70795625(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	OGT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: OGT

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).