Detail Information

Basic Information:


  VIRBase ID:  

HHID00053687

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           CUL2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p CUL2
miRBase
Accession/Entrez ID		 MIMAT0000461 8453
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CUL2
chr10:35362701(-) A-I      intronic
chr10:35362700(-) A-I      intronic
chr10:35369603(-) A-I      intronic
chr10:35362708(-) A-I      intronic
chr10:35332453(-) A-I      intronic
chr10:35301087(-) A-I      intronic
chr10:35362697(-) A-I      intronic
chr10:35301079(-) A-I      intronic
chr10:35319561(-) A-I      intronic
chr10:35367466(-) A-I      intronic
chr10:35369545(-) A-I      intronic
chr10:35350809(-) A-I      intronic
chr10:35362704(-) A-I      intronic
chr10:35350792(-) A-I      intronic
chr10:35301078(-) A-I      intronic
chr10:35350800(-) A-I      intronic
chr10:35326688(-) A-I      intronic
chr10:35369885(-) A-I      intronic
chr10:35375482(-) A-I      intronic
chr10:35375479(-) A-I      intronic
chr10:35325881(-) A-I      intronic
chr10:35371138(-) A-I      intronic
chr10:35300169(-) A-I      intronic
chr10:35370979(-) A-I      intronic
chr10:35370965(-) A-I      intronic
chr10:35305675(-) A-I      intronic
chr10:35370964(-) A-I      intronic
chr10:35357935(-) A-I      intronic
chr10:35325884(-) A-I      intronic
chr10:35370738(-) A-I      intronic
chr10:35313058(-) A-I      intronic
chr10:35370683(-) A-I      intronic
chr10:35376115(-) A-I      intronic
chr10:35370662(-) A-I      intronic
chr10:35369907(-) A-I      intronic
chr10:35369656(-) A-I      intronic
chr10:35306558(-) A-I      intronic
chr10:35369633(-) A-I      intronic
chr10:35375376(-) A-I      intronic
chr10:35370699(-) A-I      intronic
chr10:35302151(-) A-I      intronic
chr10:35367352(-) A-I      intronic
chr10:35369611(-) A-I      intronic
chr10:35365858(-) A-I      intronic
chr10:35355266(-) A-I      intronic
chr10:35365733(-) A-I      intronic
chr10:35357863(-) A-I      intronic
chr10:35356461(-) A-I      intronic
chr10:35356066(-) A-I      intronic
chr10:35356029(-) A-I      intronic
chr10:35355500(-) A-I      intronic
chr10:35354710(-) A-I      intronic
chr10:35319567(-) A-I      intronic
chr10:35354704(-) A-I      intronic
chr10:35354687(-) A-I      intronic
chr10:35354425(-) A-I      intronic
chr10:35319721(-) A-I      intronic
chr10:35357864(-) A-I      intronic
chr10:35319738(-) A-I      intronic
chr10:35354359(-) A-I      intronic
chr10:35353717(-) A-I      intronic
chr10:35350808(-) A-I      intronic
chr10:35366194(-) A-I      intronic
chr10:35330702(-) A-I      intronic
chr10:35375040(-) A-I      intronic
chr10:35325822(-) A-I      intronic
chr10:35325864(-) A-I      intronic
chr10:35306456(-) A-I      intronic
chr10:35373067(-) A-I      intronic
chr10:35375341(-) A-I      intronic
chr10:35300446(-) A-I      intronic
chr10:35358222(-) A-I      intronic
chr10:35375380(-) A-I      intronic
chr10:35375180(-) A-I      intronic
chr10:35304102(-) A-I      intronic
chr10:35300483(-) A-I      intronic
chr10:35300470(-) A-I      intronic
chr10:35353679(-) A-I      intronic
chr10:35353750(-) A-I      intronic
chr10:35325851(-) A-I      intronic
chr10:35357934(-) A-I      intronic
chr10:35305688(-) A-I      intronic
chr10:35300540(-) A-I      intronic
chr10:35369583(-) A-I      intronic
chr10:35325895(-) A-I      intronic
chr10:35330478(-) A-I      intronic
chr10:35353721(-) A-I      intronic
chr10:35375599(-) A-I      intronic
chr10:35300103(-) A-I      intronic
chr10:35362661(-) A-I      intronic
chr10:35356028(-) A-I      intronic
chr10:35375190(-) A-I      intronic
chr10:35376101(-) A-I      intronic
chr10:35358455(-) A-I      intronic
chr10:35301082(-) A-I      intronic
chr10:35377975(-) A-I      intronic
chr10:35357895(-) A-I      intronic
chr10:35376189(-) A-I      intronic
chr10:35369655(-) A-I      intronic
chr10:35374122(-) A-I      intronic
chr10:35307103(-) A-I      intronic
chr10:35311829(-) A-I      intronic
chr10:35327039(-) A-I      intronic
chr10:35330573(-) A-I      intronic
chr10:35319562(-) A-I      intronic
chr10:35377981(-) A-I      intronic
chr10:35325826(-) A-I      intronic
chr10:35369524(-) A-I      intronic
chr10:35356482(-) A-I      intronic
chr10:35375174(-) A-I      intronic
chr10:35369664(-) A-I      intronic
chr10:35357925(-) A-I      intronic
chr10:35362725(-) A-I      intronic
chr10:35366501(-) A-I      intronic
chr10:35366580(-) A-I      intronic
chr10:35356513(-) A-I      intronic
chr10:35330729(-) A-I      intronic
chr10:35358070(-) A-I      intronic
chr10:35358387(-) A-I      intronic
chr10:35369602(-) A-I      intronic
chr10:35309925(-) A-I      intronic
chr10:35371151(-) A-I      intronic
chr10:35376144(-) A-I      intronic
chr10:35365761(-) A-I      intronic
chr10:35362785(-) A-I      intronic
chr10:35300097(-) A-I      intronic
chr10:35375318(-) A-I      intronic
chr10:35365868(-) A-I      intronic
chr10:35375207(-) A-I      intronic
chr10:35301119(-) A-I      intronic
chr10:35355499(-) A-I      intronic
chr10:35358067(-) A-I      intronic
chr10:35330737(-) A-I      intronic
chr10:35362605(-) A-I      intronic
chr10:35367515(-) A-I      intronic
chr10:35355268(-) A-I      intronic
chr10:35301074(-) A-I      intronic
chr10:35367388(-) A-I      intronic
chr10:35369950(-) A-I      intronic
chr10:35301120(-) A-I      intronic
chr10:35375602(-) A-I      intronic
chr10:35375326(-) A-I      intronic
chr10:35319739(-) A-I      intronic
chr10:35300422(-) A-I      intronic
chr10:35355350(-) A-I      intronic
chr10:35363517(-) A-I      intronic
chr10:35375168(-) A-I      intronic
chr10:35357298(-) A-I      intronic
chr10:35369931(-) A-I      intronic
chr10:35356026(-) A-I      intronic
chr10:35371007(-) A-I      intronic
chr10:35353743(-) A-I      intronic
chr10:35300411(-) A-I      intronic
chr10:35353697(-) A-I      intronic
chr10:35376118(-) A-I      intronic
chr10:35369939(-) A-I      intronic
chr10:35375181(-) A-I      intronic
chr10:35367361(-) A-I      intronic
chr10:35358463(-) A-I      intronic
chr10:35300538(-) A-I      intronic
chr10:35374996(-) A-I      intronic
chr10:35347697(-) A-I      intronic
chr10:35300087(-) A-I      intronic
chr10:35297903(-) A-I      3'UTR
chr10:35370655(-) A-I      intronic
chr10:35366525(-) A-I      intronic
chr10:35344629(-) A-I      intronic
chr10:35358393(-) A-I      intronic
chr10:35300018(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CUL2
chr10:35297958(-) T-C exon 3'UTR    22484847
chr10:35353697(-) A-G intron -    22484847
chr10:35355350(-) A-G intron -    22484847
chr10:35375376(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CUL2
chr10:35297524-35297525(-) m6A 3'UTR       27773535
chr10:35297560-35297561(-) m6A 3'UTR       27773535
chr10:35297626-35297627(-) m6A 3'UTR       27773535
chr10:35298830-35298831(-) m6A 3'UTR       27773535//22608085
chr10:35298888-35298889(-) m6A 3'UTR       27773535//22608085
chr10:35298903-35298904(-) m6A 3'UTR       27773535//22608085
chr10:35299028-35299029(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr10:35299162-35299163(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr10:35299296-35299297(-) m6A 3'UTR//CDS       27773535
chr10:35300857-35300858(-) m6A 3'UTR//CDS//intron       24981863//27773535
chr10:35300879-35300880(-) m6A 3'UTR//CDS//intron       24981863//27773535
chr10:35302636-35302637(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35302670-35302671(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35302687-35302688(-) m6A 3'UTR//CDS       24981863//27773535
chr10:35343382-35343383(-) m6A 3'UTR//CDS       24981863
chr10:35343419-35343420(-) m6A 3'UTR//CDS       24981863
chr10:35379521-35379522(-) m6A 5'UTR       25456834//24981863
chr10:35379527-35379528(-) m1A 5'UTR       26863196

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
CUL2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: CUL2

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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