Detail Information

Basic Information:


  VIRBase ID:  

HHID00053682

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           SHOC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p SHOC2
miRBase
Accession/Entrez ID		 MIMAT0000461 8036
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NSLH1//SIAA0862//SOC2//SUR8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SHOC2
chr10:112685364(+) A-I      intronic
chr10:112685398(+) A-I      intronic
chr10:112757954(+) A-I      intronic
chr10:112735810(+) A-I      intronic
chr10:112685436(+) A-I      intronic
chr10:112685491(+) A-I      intronic
chr10:112756135(+) A-I      intronic
chr10:112736322(+) A-I      intronic
chr10:112746361(+) A-I      intronic
chr10:112757796(+) A-I      intronic
chr10:112684587(+) A-I      intronic
chr10:112684678(+) A-I      intronic
chr10:112685261(+) A-I      intronic
chr10:112685328(+) A-I      intronic
chr10:112685334(+) A-I      intronic
chr10:112761523(+) A-I      intronic
chr10:112758031(+) A-I      intronic
chr10:112685252(+) A-I      intronic
chr10:112685345(+) A-I      intronic
chr10:112736309(+) A-I      intronic
chr10:112761692(+) A-I      intronic
chr10:112720482(+) A-I      intronic
chr10:112764791(+) A-I      intronic
chr10:112685346(+) A-I      intronic
chr10:112735055(+) A-I      intronic
chr10:112684750(+) A-I      intronic
chr10:112759280(+) A-I      intronic
chr10:112685424(+) A-I      intronic
chr10:112760972(+) A-I      intronic
chr10:112720618(+) A-I      intronic
chr10:112761759(+) A-I      intronic
chr10:112684613(+) A-I      intronic
chr10:112685453(+) A-I      intronic
chr10:112684670(+) A-I      intronic
chr10:112684669(+) A-I      intronic
chr10:112761636(+) A-I      intronic
chr10:112685492(+) A-I      intronic
chr10:112685451(+) A-I      intronic
chr10:112699076(+) A-I      intronic
chr10:112685450(+) A-I      intronic
chr10:112685444(+) A-I      intronic
chr10:112764790(+) A-I      intronic
chr10:112685458(+) A-I      intronic
chr10:112685435(+) A-I      intronic
chr10:112685437(+) A-I      intronic
chr10:112732369(+) A-I      intronic
chr10:112702183(+) A-I      intronic
chr10:112684590(+) A-I      intronic
chr10:112759294(+) A-I      intronic
chr10:112687872(+) A-I      intronic
chr10:112699187(+) A-I      intronic
chr10:112684570(+) A-I      intronic
chr10:112685405(+) A-I      intronic
chr10:112685315(+) A-I      intronic
chr10:112684677(+) A-I      intronic
chr10:112684618(+) A-I      intronic
chr10:112684679(+) A-I      intronic
chr10:112728450(+) A-I      intronic
chr10:112699199(+) A-I      intronic
chr10:112684682(+) A-I      intronic
chr10:112764860(+) A-I      intronic
chr10:112761095(+) A-I      intronic
chr10:112685381(+) A-I      intronic
chr10:112759279(+) A-I      intronic
chr10:112685356(+) A-I      intronic
chr10:112685380(+) A-I      intronic
chr10:112685316(+) A-I      intronic
chr10:112685489(+) A-I      intronic
chr10:112696792(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SHOC2
chr10:112696792(+) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SHOC2
chr10:112679797-112679798(+) m6A exon//intron       24981863
chr10:112723884-112723885(+) m6A 5'UTR//exon//intron       24981863
chr10:112724144-112724145(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:112724241-112724242(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:112724248-112724249(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:112724282-112724283(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:112724342-112724343(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr10:112724356-112724357(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr10:112724432-112724433(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr10:112724496-112724497(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:112724655-112724656(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:112724744-112724745(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr10:112724753-112724754(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr10:112724763-112724764(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr10:112724789-112724790(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085
chr10:112724799-112724800(+) m6A CDS//exon//intron       24284625//24981863//22575960//22608085
chr10:112745434-112745435(+) m6A CDS//exon//intron       22608085
chr10:112745457-112745458(+) m6A CDS//exon//intron       22608085
chr10:112745497-112745498(+) m6A CDS//exon//intron       -
chr10:112745505-112745506(+) m6A CDS//exon//intron       -
chr10:112771475-112771476(+) m6A CDS       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
SHOC2
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: SHOC2

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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