Basic Information:

  VIRBase ID:  

HHID00053675

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          VEGFA:  NM_001171622     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	VEGFA
miRBase Accession/Entrez ID	MIMAT0000461	7422
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVCD1//VEGF//VPF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VEGFA	chr6:43738036-43738037(+) m6A 5'UTR//exon       24981863 chr6:43738048-43738049(+) m6A 5'UTR//exon       24981863 chr6:43738124-43738125(+) m6A 5'UTR//exon       24981863 chr6:43738139-43738140(+) m6A 5'UTR//exon       24284625 chr6:43738249-43738250(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr6:43738450-43738451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738458-43738459(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738509-43738510(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738601-43738602(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738738-43738739(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr6:43738825-43738826(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738980-43738981(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43738987-43738988(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43741786-43741787(+) m6A exon//intron       - chr6:43745461-43745462(+) m6A exon//intron       27773535 chr6:43745833-43745834(+) m6A exon//intron       - chr6:43745926-43745927(+) m6A exon//intron       - chr6:43746210-43746211(+) m6A CDS//exon//intron       24284625//24209618 chr6:43746477-43746478(+) m6A exon//intron       24981863 chr6:43746646-43746647(+) m6A CDS//exon//intron       24981863 chr6:43746762-43746763(+) m6A exon//intron       24981863 chr6:43747745-43747746(+) m6A exon//intron       - chr6:43748323-43748324(+) m6A exon//intron       - chr6:43749769-43749770(+) m6A CDS//exon//intron       24284625 chr6:43749775-43749776(+) m6A CDS//exon//intron       24284625 chr6:43752338-43752339(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752360-43752361(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752386-43752387(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752423-43752424(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752441-43752442(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752463-43752464(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752498-43752499(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752632-43752633(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:43752790-43752791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752852-43752853(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752961-43752962(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752971-43752972(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753013-43753014(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753021-43753022(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753022-43753023(+) Cm 3'UTR//exon       - chr6:43753046-43753047(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753082-43753083(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753211-43753212(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753243-43753244(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753288-43753289(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43753339-43753340(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753362-43753363(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753387-43753388(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753464-43753465(+) m6A 3'UTR//exon       24284625//24209618//22575960 chr6:43753562-43753563(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	VEGFA	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HeLa cells     25063809

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: VEGFA

Evidence Support:

Weak-Evidence	HITS-CLIP//PAR-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).