Detail Information

Basic Information:


  VIRBase ID:  

HHID00053658

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           SLC7A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p SLC7A1
miRBase
Accession/Entrez ID		 MIMAT0000461 6541
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATRC1//CAT-1//ERR//HCAT1//REC1L

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC7A1
chr13:30165123(-) A-I      intronic
chr13:30162644(-) A-I      intronic
chr13:30150317(-) A-I      intronic
chr13:30164990(-) A-I      intronic
chr13:30150232(-) A-I      intronic
chr13:30150299(-) A-I      intronic
chr13:30162781(-) A-I      intronic
chr13:30134017(-) A-I      intronic
chr13:30162743(-) A-I      intronic
chr13:30150347(-) A-I      intronic
chr13:30150377(-) A-I      intronic
chr13:30162779(-) A-I      intronic
chr13:30150174(-) A-I      intronic
chr13:30148946(-) A-I      intronic
chr13:30150253(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SLC7A1
chr13:30162779(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC7A1
chr13:30083687-30083688(-) m6A 3'UTR       27773535
chr13:30083728-30083729(-) m6A 3'UTR       27773535
chr13:30084103-30084104(-) m6A 3'UTR       25456834//24981863//22608085
chr13:30084118-30084119(-) m6A 3'UTR       25456834//24981863//22608085
chr13:30084167-30084168(-) m6A 3'UTR       24284625//24209618//24981863//22608085
chr13:30084276-30084277(-) m6A 3'UTR       24284625//24981863//22608085
chr13:30084361-30084362(-) m6A 3'UTR       24284625//27773535
chr13:30084559-30084560(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr13:30084714-30084715(-) m6A 3'UTR       24284625//24209618//24981863
chr13:30084771-30084772(-) m6A 3'UTR       24284625//24981863
chr13:30084868-30084869(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30084883-30084884(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30084929-30084930(-) m6A 3'UTR       24284625//24981863//27773535//22575960
chr13:30085005-30085006(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr13:30085043-30085044(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr13:30085069-30085070(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27773536//22575960//22608085
chr13:30085101-30085102(-) m6A 3'UTR       24284625//25456834//27773536//22575960//22608085
chr13:30085108-30085109(-) m6A 3'UTR       24284625//25456834//27773536//22575960//22608085
chr13:30085165-30085166(-) m6A 3'UTR       25456834//27773536//22575960
chr13:30085468-30085469(-) m6A 3'UTR       -
chr13:30085577-30085578(-) m6A 3'UTR       24209618
chr13:30085675-30085676(-) m6A 3'UTR       24284625
chr13:30085703-30085704(-) Cm 3'UTR       -
chr13:30085801-30085802(-) m6A 3'UTR       24284625//27773535
chr13:30085832-30085833(-) m6A 3'UTR       24284625//27773535
chr13:30085916-30085917(-) m6A 3'UTR       24284625//27773535
chr13:30085935-30085936(-) m6A 3'UTR       24284625//27773535
chr13:30086022-30086023(-) m6A 3'UTR       27773535
chr13:30086071-30086072(-) m6A 3'UTR       27773535
chr13:30086317-30086318(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30086362-30086363(-) m6A 3'UTR       24284625//22575960
chr13:30086396-30086397(-) m6A 3'UTR       24284625//22575960
chr13:30087099-30087100(-) m6A 3'UTR       24981863
chr13:30087131-30087132(-) m6A 3'UTR       24284625//24981863
chr13:30087180-30087181(-) m6A 3'UTR       24284625//24981863
chr13:30087223-30087224(-) m6A 3'UTR       24284625//24981863
chr13:30087341-30087342(-) m6A 3'UTR       24284625//27773535
chr13:30087367-30087368(-) m6A 3'UTR       24284625//27773535
chr13:30087622-30087623(-) m6A 3'UTR       24284625//27773535//22575960
chr13:30087765-30087766(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr13:30087779-30087780(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087786-30087787(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087871-30087872(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30087878-30087879(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088030-30088031(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088146-30088147(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088180-30088181(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088212-30088213(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088245-30088246(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088265-30088266(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr13:30088352-30088353(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088413-30088414(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr13:30088522-30088523(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30088561-30088562(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr13:30088629-30088630(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30088648-30088649(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr13:30090315-30090316(-) m6A CDS       24284625//27773535//22575960
chr13:30109978-30109979(-) m6A CDS       27773535
chr13:30110227-30110228(-) m6A CDS       24284625//25456834//24981863
chr13:30110266-30110267(-) m6A CDS       24284625//25456834
chr13:30110332-30110333(-) m6A 5'UTR       24284625
chr13:30127964-30127965(-) m6A 5'UTR       24284625
chr13:30127987-30127988(-) m6A 5'UTR       24284625
chr13:30169797-30169798(-) m6A 5'UTR       24981863
chr13:30169810-30169811(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
SLC7A1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: SLC7A1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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