Detail Information

Basic Information:


  VIRBase ID:  

HHID00053644

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:           PTPN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-195-5p PTPN4
miRBase
Accession/Entrez ID		 MIMAT0000461 5775
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MEG//PTPMEG//PTPMEG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-195-5p
rs1346604530 chr17:7017676    T/C
rs1354352122 chr17:7017679    G/C
rs376953960 chr17:7017671    A/G
rs761226479 chr17:7017674    T/C
rs767045828 chr17:7017669    C/A
rs975705809 chr17:7017668    C/T
rs1230392050 chr17:7017682    C/T
rs1257736738 chr17:7017684    G/A
rs1311315368 chr17:7017686    T/C
rs1483556117 chr17:7017685    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PTPN4
chr2:120733170(+) A-I      intronic
chr2:120723904(+) A-I      intronic
chr2:120723896(+) A-I      intronic
chr2:120532437(+) A-I      intronic
chr2:120723909(+) A-I      intronic
chr2:120532440(+) A-I      intronic
chr2:120540359(+) A-I      intronic
chr2:120532456(+) A-I      intronic
chr2:120532474(+) A-I      intronic
chr2:120733100(+) A-I      intronic
chr2:120733154(+) A-I      intronic
chr2:120733242(+) A-I      intronic
chr2:120733701(+) A-I      intronic
chr2:120532345(+) A-I      intronic
chr2:120584400(+) A-I      intronic
chr2:120592961(+) A-I      intronic
chr2:120613514(+) A-I      intronic
chr2:120613547(+) A-I      intronic
chr2:120613562(+) A-I      intronic
chr2:120644810(+) A-I      intronic
chr2:120653029(+) A-I      intronic
chr2:120653030(+) A-I      intronic
chr2:120653031(+) A-I      intronic
chr2:120723891(+) A-I      intronic
chr2:120727825(+) A-I      intronic
chr2:120532488(+) A-I      intronic
chr2:120537596(+) A-I      intronic
chr2:120539793(+) A-I      intronic
chr2:120573975(+) A-I      intronic
chr2:120584338(+) A-I      intronic
chr2:120584373(+) A-I      intronic
chr2:120584455(+) A-I      intronic
chr2:120584490(+) A-I      intronic
chr2:120592784(+) A-I      intronic
chr2:120592878(+) A-I      intronic
chr2:120592922(+) A-I      intronic
chr2:120723935(+) A-I      intronic
chr2:120724069(+) A-I      intronic
chr2:120724077(+) A-I      intronic
chr2:120532339(+) A-I      intronic
chr2:120533888(+) A-I      intronic
chr2:120724838(+) A-I      intronic
chr2:120726824(+) A-I      intronic
chr2:120727264(+) A-I      intronic
chr2:120727274(+) A-I      intronic
chr2:120727705(+) A-I      intronic
chr2:120537433(+) A-I      intronic
chr2:120593435(+) A-I      intronic
chr2:120533832(+) A-I      intronic
chr2:120613510(+) A-I      intronic
chr2:120537466(+) A-I      intronic
chr2:120532347(+) A-I      intronic
chr2:120537583(+) A-I      intronic
chr2:120532414(+) A-I      intronic
chr2:120532417(+) A-I      intronic
chr2:120723928(+) A-I      intronic
chr2:120537584(+) A-I      intronic
chr2:120537438(+) A-I      intronic
chr2:120650362(+) A-I      intronic
chr2:120532475(+) A-I      intronic
chr2:120733834(+) A-I      intronic
chr2:120646849(+) A-I      intronic
chr2:120733101(+) A-I      intronic
chr2:120653057(+) A-I      intronic
chr2:120534026(+) A-I      intronic
chr2:120649101(+) A-I      intronic
chr2:120650402(+) A-I      intronic
chr2:120592830(+) A-I      intronic
chr2:120650427(+) A-I      intronic
chr2:120618506(+) A-I      intronic
chr2:120695365(+) A-I      intronic
chr2:120536939(+) A-I      intronic
chr2:120539874(+) A-I      intronic
chr2:120537511(+) A-I      intronic
chr2:120677280(+) A-I      intronic
chr2:120533881(+) A-I      intronic
chr2:120533957(+) A-I      intronic
chr2:120584458(+) A-I      intronic
chr2:120653345(+) A-I      intronic
chr2:120733222(+) A-I      intronic
chr2:120534012(+) A-I      intronic
chr2:120534024(+) A-I      intronic
chr2:120733181(+) A-I      intronic
chr2:120593429(+) A-I      intronic
chr2:120532425(+) A-I      intronic
chr2:120732712(+) A-I      intronic
chr2:120534033(+) A-I      intronic
chr2:120733058(+) A-I      intronic
chr2:120584543(+) A-I      intronic
chr2:120733116(+) A-I      intronic
chr2:120733245(+) A-I      intronic
chr2:120630701(+) A-I      intronic
chr2:120566186(+) A-I      intronic
chr2:120653122(+) A-I      intronic
chr2:120733045(+) A-I      intronic
chr2:120732927(+) A-I      intronic
chr2:120653096(+) A-I      intronic
chr2:120733820(+) A-I      intronic
chr2:120653137(+) A-I      intronic
chr2:120733180(+) A-I      intronic
chr2:120537414(+) A-I      intronic
chr2:120533972(+) A-I      intronic
chr2:120695401(+) A-I      intronic
chr2:120573902(+) A-I      intronic
chr2:120726789(+) A-I      intronic
chr2:120650367(+) A-I      intronic
chr2:120537522(+) A-I      intronic
chr2:120732814(+) A-I      intronic
chr2:120653208(+) A-I      intronic
chr2:120539897(+) A-I      intronic
chr2:120636437(+) A-I      intronic
chr2:120681559(+) A-I      intronic
chr2:120732828(+) A-I      intronic
chr2:120653378(+) A-I      intronic
chr2:120733087(+) A-I      intronic
chr2:120613449(+) A-I      intronic
chr2:120576142(+) A-I      intronic
chr2:120732966(+) A-I      intronic
chr2:120537486(+) A-I      intronic
chr2:120636688(+) A-I      intronic
chr2:120675227(+) A-I      intronic
chr2:120566187(+) A-I      intronic
chr2:120539875(+) A-I      intronic
chr2:120532418(+) A-I      intronic
chr2:120613587(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PTPN4
chr2:120695401(+) A-I intron -    21960545
chr2:120532418(+) A-G intron -    22484847
chr2:120533881(+) A-G intron -    22484847
chr2:120533957(+) A-G intron -    22484847
chr2:120533972(+) A-G intron -    22484847
chr2:120534012(+) A-G intron -    22484847
chr2:120534024(+) A-G intron -    22484847
chr2:120534026(+) A-G intron -    22484847
chr2:120534033(+) A-G intron -    22484847
chr2:120536939(+) A-G intron -    22484847
chr2:120539874(+) A-G intron -    22484847
chr2:120539875(+) A-G intron -    22484847
chr2:120576142(+) A-G intron -    22484847
chr2:120592830(+) A-G intron -    22484847
chr2:120593429(+) A-G intron -    22484847
chr2:120613449(+) A-G intron -    22484847
chr2:120613587(+) A-G intron -    22484847
chr2:120727836(+) A-G intron -    22484847
chr2:120732712(+) A-G intron -    22484847
chr2:120732814(+) A-G intron -    22484847
chr2:120732822(+) A-G intron -    22484847
chr2:120733101(+) A-G intron -    22484847
chr2:120733180(+) A-G intron -    22484847
chr2:120733181(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PTPN4
chr2:120517574-120517575(+) m6A 5'UTR//exon       25456834//24981863//22608085
chr2:120517624-120517625(+) m6A 5'UTR//exon       25456834//22608085
chr2:120734618-120734619(+) m6A 3'UTR//CDS       24981863//22608085
chr2:120734679-120734680(+) m6A 3'UTR       24209618//24981863//22608085
chr2:120734753-120734754(+) m6A 3'UTR       24209618//24981863//22608085
chr2:120734763-120734764(+) m6A 3'UTR       24209618//24981863//22608085
chr2:120734772-120734773(+) m6A 3'UTR       24209618//24981863//22608085
chr2:120734844-120734845(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr2:120734866-120734867(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr2:120734955-120734956(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr2:120735018-120735019(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-195-5p
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
PTPN4
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-195-5p
Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Deferoxamine hydrochloride 62880 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Amonafide 50515 Drug resistant
Justicidin B 442882 Drug resistant
Entinostat 4261 Drug resistant
5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
Antineoplastic-92909 261046 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
Emofolin sodium 135475347 Drug resistant
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
Pararosaniline hydrochloride 11292 Drug sensitive
Erigerol 101318126 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
xenorhabdin 1 - Drug resistant
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug sensitive
crotoxin cd - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-195-5p
Palmitic acid 985 Drug interaction    RC00003301
Curcumin 969516 Drug interaction    RC00003314
Benzothiazole 7222 Drug interaction    RC00003308
Gemcitabine 60750 Drug interaction    RC00003311
D-Glucose 5793 Drug interaction    RC00003307
Temozolomide 5394 Drug interaction    RC00003306
Eloxatine 5310940 Drug interaction    RC00003315
Imatinib 5291 Drug interaction    RC00003305
Diethylstilbestrol 448537 Drug interaction    RC00003313
Paclitaxel 36314 Drug interaction    RC00003310
5-Fluorouracil 3385 Drug interaction    RC00003304
Doxorubicin 31703 Drug interaction    RC00003309
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303
Celecoxib 2662 Drug interaction    RC00003302
Docetaxel 148124 Drug interaction    RC00003312
platinum-based doublet chemotherapy - Drug interaction    RC00003316
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317
Aidi injection - Drug interaction    RC00003318
Trastuzumab - Drug interaction    RC00003320
Glucocorticoid - Drug interaction    RC00003319
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-195-5p
Oxaliplatin 9887053       29956811
5-Fluorouracil 3385       29852230
5-Fluorouracil 3385       29956811
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-195-5p
Interactor2: PTPN4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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