Basic Information:

  VIRBase ID:  

HHID00053614

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          SMAD3:  NM_005902     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	SMAD3
miRBase Accession/Entrez ID	MIMAT0000461	4088
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC193//HsT17436//JV15-2//LDS1C//LDS3//MADH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMAD3	chr15:67452930(+) A-I      intronic chr15:67452962(+) A-I      intronic chr15:67358882(+) A-I      intronic chr15:67451670(+) A-I      intronic chr15:67451671(+) A-I      intronic chr15:67452947(+) A-I      intronic chr15:67394254(+) A-I      intronic chr15:67451683(+) A-I      intronic chr15:67451672(+) A-I      intronic chr15:67452950(+) A-I      intronic chr15:67394253(+) A-I      intronic chr15:67362173(+) A-I      intronic chr15:67403460(+) A-I      intronic chr15:67451592(+) A-I      intronic chr15:67451581(+) A-I      intronic chr15:67451570(+) A-I      intronic chr15:67416609(+) A-I      intronic chr15:67416603(+) A-I      intronic chr15:67416411(+) A-I      intronic chr15:67416365(+) A-I      intronic chr15:67416349(+) A-I      intronic chr15:67415758(+) A-I      intronic chr15:67389768(+) A-I      intronic chr15:67389769(+) A-I      intronic chr15:67415506(+) A-I      intronic chr15:67415445(+) A-I      intronic chr15:67415389(+) A-I      intronic chr15:67367127(+) A-I      intronic chr15:67452943(+) A-I      intronic chr15:67456585(+) A-I      intronic chr15:67412396(+) A-I      intronic chr15:67456466(+) A-I      intronic chr15:67389771(+) A-I      intronic chr15:67368181(+) A-I      intronic chr15:67456616(+) A-I      intronic chr15:67456372(+) A-I      intronic chr15:67412356(+) A-I      intronic chr15:67456581(+) A-I      intronic chr15:67405627(+) A-I      intronic chr15:67366170(+) A-I      intronic chr15:67456546(+) A-I      intronic chr15:67392319(+) A-I      intronic chr15:67412179(+) A-I      intronic chr15:67456542(+) A-I      intronic chr15:67456516(+) A-I      intronic chr15:67456471(+) A-I      intronic chr15:67456470(+) A-I      intronic chr15:67368088(+) A-I      intronic chr15:67366112(+) A-I      intronic chr15:67389693(+) A-I      intronic chr15:67367131(+) A-I      intronic chr15:67367102(+) A-I      intronic chr15:67367157(+) A-I      intronic chr15:67455501(+) A-I      intronic chr15:67366211(+) A-I      intronic chr15:67366195(+) A-I      intronic chr15:67366149(+) A-I      intronic chr15:67366142(+) A-I      intronic chr15:67366113(+) A-I      intronic chr15:67410310(+) A-I      intronic chr15:67455495(+) A-I      intronic chr15:67368114(+) A-I      intronic chr15:67455405(+) A-I      intronic chr15:67455376(+) A-I      intronic chr15:67453054(+) A-I      intronic chr15:67412228(+) A-I      intronic chr15:67453053(+) A-I      intronic chr15:67453034(+) A-I      intronic chr15:67453018(+) A-I      intronic chr15:67415675(+) A-I      intronic chr15:67368202(+) A-I      intronic chr15:67366106(+) A-I      intronic chr15:67366069(+) A-I      intronic chr15:67366061(+) A-I      intronic chr15:67453015(+) A-I      intronic chr15:67415386(+) A-I      intronic chr15:67453011(+) A-I      intronic chr15:67452994(+) A-I      intronic chr15:67452958(+) A-I      intronic chr15:67452927(+) A-I      intronic chr15:67452894(+) A-I      intronic chr15:67452891(+) A-I      intronic chr15:67452855(+) A-I      intronic chr15:67452839(+) A-I      intronic chr15:67415717(+) A-I      intronic chr15:67451509(+) A-I      intronic chr15:67451652(+) A-I      intronic chr15:67451609(+) A-I      intronic chr15:67451606(+) A-I      intronic chr15:67456143(+) A-I      intronic chr15:67410283(+) A-I      intronic chr15:67412332(+) A-I      intronic chr15:67451478(+) A-I      intronic chr15:67412397(+) A-I      intronic chr15:67367047(+) A-I      intronic chr15:67368106(+) A-I      intronic chr15:67363921(+) A-I      intronic chr15:67455555(+) A-I      intronic chr15:67416500(+) A-I      intronic chr15:67455512(+) A-I      intronic chr15:67367189(+) A-I      intronic chr15:67415375(+) A-I      intronic chr15:67415739(+) A-I      intronic chr15:67415579(+) A-I      intronic chr15:67443457(+) A-I      intronic chr15:67415685(+) A-I      intronic chr15:67368133(+) A-I      intronic chr15:67368119(+) A-I      intronic chr15:67452882(+) A-I      intronic chr15:67368174(+) A-I      intronic chr15:67367193(+) A-I      intronic chr15:67416427(+) A-I      intronic chr15:67366220(+) A-I      intronic chr15:67416492(+) A-I      intronic chr15:67362144(+) A-I      intronic chr15:67367097(+) A-I      intronic chr15:67476581(+) A-I      intronic chr15:67368185(+) A-I      intronic chr15:67415373(+) A-I      intronic chr15:67415687(+) A-I      intronic chr15:67410410(+) A-I      intronic chr15:67362114(+) A-I      intronic chr15:67421012(+) A-I      intronic chr15:67410364(+) A-I      intronic chr15:67455333(+) A-I      intronic chr15:67368100(+) A-I      intronic chr15:67416601(+) A-I      intronic chr15:67410351(+) A-I      intronic chr15:67452978(+) A-I      intronic chr15:67415787(+) A-I      intronic chr15:67405710(+) A-I      intronic chr15:67455441(+) A-I      intronic chr15:67366158(+) A-I      intronic chr15:67368198(+) A-I      intronic chr15:67455332(+) A-I      intronic chr15:67368203(+) A-I      intronic chr15:67363962(+) A-I      intronic chr15:67415671(+) A-I      intronic chr15:67415676(+) A-I      intronic chr15:67405711(+) A-I      intronic chr15:67405702(+) A-I      intronic chr15:67368210(+) A-I      intronic chr15:67416395(+) A-I      intronic chr15:67416561(+) A-I      intronic chr15:67415408(+) A-I      intronic chr15:67415680(+) A-I      intronic chr15:67368146(+) A-I      intronic chr15:67410342(+) A-I      intronic chr15:67416562(+) A-I      intronic chr15:67456395(+) A-I      intronic chr15:67362119(+) A-I      intronic chr15:67478497(+) A-I      intronic chr15:67368044(+) A-I      intronic chr15:67452949(+) A-I      intronic chr15:67363875(+) A-I      intronic chr15:67483483(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMAD3	chr15:67368146(+) A-G intron -    22484847 chr15:67415675(+) A-G intron -    22484847 chr15:67451478(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD3	chr15:67356224-67356225(+) m6A 5'UTR       24981863 chr15:67356275-67356276(+) m6A 5'UTR       24981863 chr15:67358549-67358550(+) m1A CDS//intron       26863196//26863410 chr15:67358614-67358615(+) m6A CDS//intron       24284625//24981863//26404942 chr15:67390932-67390933(+) m6A 5'UTR//intron       24284625 chr15:67418223-67418224(+) m6A 5'UTR//intron       24981863 chr15:67457312-67457313(+) m6A 5'UTR//CDS//exon       24284625 chr15:67457419-67457420(+) m6A CDS//exon       24284625//24981863 chr15:67457677-67457678(+) m6A CDS//exon       24284625//24981863 chr15:67459093-67459094(+) m6A 5'UTR//intron       24284625//24981863 chr15:67459118-67459119(+) m6A 5'UTR//CDS//exon       24284625//24981863 chr15:67459154-67459155(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942 chr15:67459173-67459174(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462900-67462901(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462971-67462972(+) m6A exon//intron       24284625//24981863 chr15:67466703-67466704(+) m6A exon//intron       24284625 chr15:67466805-67466806(+) m6A exon//intron       24284625 chr15:67473784-67473785(+) Cm CDS//intron       - chr15:67482753-67482754(+) m6A CDS//exon//intron       24284625//24209618//24981863 chr15:67482876-67482877(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr15:67482943-67482944(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483023-67483024(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483035-67483036(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483056-67483057(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483073-67483074(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483144-67483145(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483180-67483181(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483229-67483230(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483246-67483247(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483310-67483311(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483358-67483359(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483405-67483406(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483430-67483431(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483480-67483481(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483512-67483513(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483525-67483526(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483562-67483563(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483916-67483917(+) m6A 3'UTR//intron       24284625//24981863 chr15:67483927-67483928(+) m6A 3'UTR//intron       24284625//24981863 chr15:67484050-67484051(+) m6A 3'UTR//intron       26404942 chr15:67484252-67484253(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484320-67484321(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484329-67484330(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484334-67484335(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484616-67484617(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr15:67484642-67484643(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484675-67484676(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484712-67484713(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484720-67484721(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484730-67484731(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484830-67484831(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr15:67484870-67484871(+) m6A 3'UTR//intron       24284625//24209618 chr15:67484878-67484879(+) m6A 3'UTR//intron       24284625//24209618 chr15:67485027-67485028(+) m6A 3'UTR//intron       24981863 chr15:67485134-67485135(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485187-67485188(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485202-67485203(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485289-67485290(+) m6A 3'UTR//exon       26404942 chr15:67485323-67485324(+) m6A 3'UTR//exon       26404942 chr15:67485510-67485511(+) m6A 3'UTR//exon       26404942 chr15:67485525-67485526(+) m6A 3'UTR       26404942 chr15:67485548-67485549(+) m6A 3'UTR       26404942 chr15:67485684-67485685(+) m6A 3'UTR       24981863 chr15:67485711-67485712(+) m6A 3'UTR       24981863 chr15:67485871-67485872(+) m6A 3'UTR       24284625 chr15:67485909-67485910(+) m6A 3'UTR       24284625 chr15:67485924-67485925(+) m6A 3'UTR       24284625 chr15:67485951-67485952(+) m6A 3'UTR       24284625 chr15:67486071-67486072(+) m6A 3'UTR       26404942 chr15:67486164-67486165(+) m6A 3'UTR       26404942 chr15:67486385-67486386(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486439-67486440(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486513-67486514(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486518-67486519(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486677-67486678(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486744-67486745(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486762-67486763(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486784-67486785(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486799-67486800(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486908-67486909(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486917-67486918(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486972-67486973(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085 chr15:67487053-67487054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487060-67487061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487074-67487075(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487094-67487095(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487142-67487143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487253-67487254(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67487285-67487286(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	SMAD3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: SMAD3

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).