Basic Information:

  VIRBase ID:  

HHID00053563

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-195-5p:  MIMAT0000461          CALU:  NR_074086     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-195-5p	CALU
miRBase Accession/Entrez ID	MIMAT0000461	813
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-195-5p	rs1346604530 chr17:7017676    T/C rs1354352122 chr17:7017679    G/C rs376953960 chr17:7017671    A/G rs761226479 chr17:7017674    T/C rs767045828 chr17:7017669    C/A rs975705809 chr17:7017668    C/T rs1230392050 chr17:7017682    C/T rs1257736738 chr17:7017684    G/A rs1311315368 chr17:7017686    T/C rs1483556117 chr17:7017685    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CALU	chr7:128406164(+) A-I      intronic chr7:128406531(+) A-I      intronic chr7:128406622(+) A-I      intronic chr7:128386649(+) A-I      intronic chr7:128406050(+) A-I      intronic chr7:128406798(+) A-I      intronic chr7:128406072(+) A-I      intronic chr7:128403510(+) A-I      intronic chr7:128403505(+) A-I      intronic chr7:128403497(+) A-I      intronic chr7:128403491(+) A-I      intronic chr7:128403452(+) A-I      intronic chr7:128402942(+) A-I      intronic chr7:128402866(+) A-I      intronic chr7:128402838(+) A-I      intronic chr7:128402764(+) A-I      intronic chr7:128402760(+) A-I      intronic chr7:128392948(+) A-I      intronic chr7:128392936(+) A-I      intronic chr7:128392884(+) A-I      intronic chr7:128392839(+) A-I      intronic chr7:128392838(+) A-I      intronic chr7:128392778(+) A-I      intronic chr7:128391670(+) A-I      intronic chr7:128391262(+) A-I      intronic chr7:128390242(+) A-I      intronic chr7:128390237(+) A-I      intronic chr7:128390188(+) A-I      intronic chr7:128390167(+) A-I      intronic chr7:128390135(+) A-I      intronic chr7:128387102(+) A-I      intronic chr7:128386940(+) A-I      intronic chr7:128386938(+) A-I      intronic chr7:128386903(+) A-I      intronic chr7:128386647(+) A-I      intronic chr7:128386637(+) A-I      intronic chr7:128386473(+) A-I      intronic chr7:128385645(+) A-I      intronic chr7:128385622(+) A-I      intronic chr7:128385538(+) A-I      intronic chr7:128385424(+) A-I      intronic chr7:128384166(+) A-I      intronic chr7:128384153(+) A-I      intronic chr7:128383750(+) A-I      intronic chr7:128380984(+) A-I      intronic chr7:128406692(+) A-I      intronic chr7:128406666(+) A-I      intronic chr7:128406612(+) A-I      intronic chr7:128406583(+) A-I      intronic chr7:128402862(+) A-I      intronic chr7:128404395(+) A-I      intronic chr7:128404489(+) A-I      intronic chr7:128405076(+) A-I      intronic chr7:128405157(+) A-I      intronic chr7:128405204(+) A-I      intronic chr7:128405342(+) A-I      intronic chr7:128406111(+) A-I      intronic chr7:128409667(+) A-I      3'UTR chr7:128403336(+) A-I      intronic chr7:128391073(+) A-I      intronic chr7:128393013(+) A-I      intronic chr7:128392758(+) A-I      intronic chr7:128385544(+) A-I      intronic chr7:128384005(+) A-I      intronic chr7:128392868(+) A-I      intronic chr7:128390093(+) A-I      intronic chr7:128400699(+) A-I      intronic chr7:128391599(+) A-I      intronic chr7:128402906(+) A-I      intronic chr7:128391638(+) A-I      intronic chr7:128386401(+) A-I      intronic chr7:128392904(+) A-I      intronic chr7:128405121(+) A-I      intronic chr7:128405492(+) A-I      intronic chr7:128385548(+) A-I      intronic chr7:128399996(+) A-I      intronic chr7:128406110(+) A-I      intronic chr7:128392809(+) A-I      intronic chr7:128406064(+) A-I      intronic chr7:128405007(+) A-I      intronic chr7:128402850(+) A-I      intronic chr7:128404296(+) A-I      intronic chr7:128404321(+) A-I      intronic chr7:128403418(+) A-I      intronic chr7:128385585(+) A-I      intronic chr7:128385608(+) A-I      intronic chr7:128406151(+) A-I      intronic chr7:128403424(+) A-I      intronic chr7:128402995(+) A-I      intronic chr7:128386486(+) A-I      intronic chr7:128405449(+) A-I      intronic chr7:128406663(+) A-I      intronic chr7:128404372(+) A-I      intronic chr7:128405354(+) A-I      intronic chr7:128392832(+) A-I      intronic chr7:128383694(+) A-I      intronic chr7:128383732(+) A-I      intronic chr7:128386758(+) A-I      intronic chr7:128400089(+) A-I      intronic chr7:128386655(+) A-I      intronic chr7:128393005(+) A-I      intronic chr7:128386474(+) A-I      intronic chr7:128406030(+) A-I      intronic chr7:128384101(+) A-I      intronic chr7:128405368(+) A-I      intronic chr7:128404421(+) A-I      intronic chr7:128384004(+) A-I      intronic chr7:128392939(+) A-I      intronic chr7:128391088(+) A-I      intronic chr7:128386780(+) A-I      intronic chr7:128383689(+) A-I      intronic chr7:128404213(+) A-I      intronic chr7:128402814(+) A-I      intronic chr7:128391660(+) A-I      intronic chr7:128383716(+) A-I      intronic chr7:128383832(+) A-I      intronic chr7:128405125(+) A-I      intronic chr7:128404414(+) A-I      intronic chr7:128390026(+) A-I      intronic chr7:128403427(+) A-I      intronic chr7:128383820(+) A-I      intronic chr7:128406137(+) A-I      intronic chr7:128393006(+) A-I      intronic chr7:128386608(+) A-I      intronic chr7:128392922(+) A-I      intronic chr7:128405048(+) A-I      intronic chr7:128385532(+) A-I      intronic chr7:128404350(+) A-I      intronic chr7:128391283(+) A-I      intronic chr7:128404432(+) A-I      intronic chr7:128404437(+) A-I      intronic chr7:128405306(+) A-I      intronic chr7:128386329(+) A-I      intronic chr7:128405458(+) A-I      intronic chr7:128403422(+) A-I      intronic chr7:128403397(+) A-I      intronic chr7:128400708(+) A-I      intronic chr7:128390161(+) A-I      intronic chr7:128386351(+) A-I      intronic chr7:128386274(+) A-I      intronic chr7:128393018(+) A-I      intronic chr7:128384156(+) A-I      intronic chr7:128404342(+) A-I      intronic chr7:128402998(+) A-I      intronic chr7:128392878(+) A-I      intronic chr7:128406216(+) A-I      intronic chr7:128402860(+) A-I      intronic chr7:128392808(+) A-I      intronic chr7:128402901(+) A-I      intronic chr7:128391292(+) A-I      intronic chr7:128392789(+) A-I      intronic chr7:128402798(+) A-I      intronic chr7:128403436(+) A-I      intronic chr7:128391195(+) A-I      intronic chr7:128402930(+) A-I      intronic chr7:128393036(+) A-I      intronic chr7:128406762(+) A-I      intronic chr7:128403423(+) A-I      intronic chr7:128391221(+) A-I      intronic chr7:128404467(+) A-I      intronic chr7:128403464(+) A-I      intronic chr7:128406199(+) A-I      intronic chr7:128383626(+) A-I      intronic chr7:128400074(+) A-I      intronic chr7:128386962(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CALU	chr7:128392868(+) A-I intron -    15258596 chr7:128392873(+) A-I intron -    15258596 chr7:128392878(+) A-I intron -    15258596 chr7:128393006(+) A-I intron -    15258596 chr7:128393013(+) A-I intron -    15258596 chr7:128393018(+) A-I intron -    15258596 chr7:128384005(+) A-I intron -    22327324 chr7:128405306(+) A-I intron -    22327324 chr7:128391674(+) A-I intron -    21960545 chr7:128406110(+) A-I intron -    21960545 chr7:128406151(+) A-I intron -    21960545 chr7:128385418(+) A-I intron -    21960545 chr7:128390026(+) A-I intron -    21960545 chr7:128405007(+) A-I intron -    21960545 chr7:128405048(+) A-I intron -    21960545 chr7:128383694(+) A-G intron -    22484847 chr7:128383732(+) A-G intron -    22484847 chr7:128383991(+) A-G intron -    22484847 chr7:128384004(+) A-G intron -    22484847 chr7:128384005(+) A-G intron -    22484847 chr7:128384100(+) A-G intron -    22484847 chr7:128384101(+) A-G intron -    22484847 chr7:128384140(+) A-G intron -    22484847 chr7:128385419(+) A-G intron -    22484847 chr7:128385532(+) A-G intron -    22484847 chr7:128385562(+) A-G intron -    22484847 chr7:128386274(+) A-G intron -    22484847 chr7:128386401(+) A-G intron -    22484847 chr7:128386608(+) A-G intron -    22484847 chr7:128390003(+) A-G intron -    22484847 chr7:128390161(+) A-G intron -    22484847 chr7:128391089(+) A-G intron -    22484847 chr7:128391094(+) A-G intron -    22484847 chr7:128391195(+) A-G intron -    22484847 chr7:128391221(+) A-G intron -    22484847 chr7:128392808(+) A-G intron -    22484847 chr7:128392809(+) A-G intron -    22484847 chr7:128392832(+) A-G intron -    22484847 chr7:128392868(+) A-G intron -    22484847 chr7:128392873(+) A-G intron -    22484847 chr7:128392878(+) A-G intron -    22484847 chr7:128392904(+) A-G intron -    22484847 chr7:128392922(+) A-G intron -    22484847 chr7:128392939(+) A-G intron -    22484847 chr7:128393006(+) A-G intron -    22484847 chr7:128393013(+) A-G intron -    22484847 chr7:128402798(+) A-G intron -    22484847 chr7:128402814(+) A-G intron -    22484847 chr7:128402820(+) A-G intron -    22484847 chr7:128402860(+) A-G intron -    22484847 chr7:128402901(+) A-G intron -    22484847 chr7:128402902(+) A-G intron -    22484847 chr7:128402904(+) A-G intron -    22484847 chr7:128402906(+) A-G intron -    22484847 chr7:128402983(+) A-G intron -    22484847 chr7:128402998(+) A-G intron -    22484847 chr7:128403335(+) A-G intron -    22484847 chr7:128403407(+) A-G intron -    22484847 chr7:128403418(+) A-G intron -    22484847 chr7:128403421(+) A-G intron -    22484847 chr7:128403422(+) A-G intron -    22484847 chr7:128403423(+) A-G intron -    22484847 chr7:128403424(+) A-G intron -    22484847 chr7:128403425(+) A-G intron -    22484847 chr7:128403427(+) A-G intron -    22484847 chr7:128403464(+) A-G intron -    22484847 chr7:128404350(+) A-G intron -    22484847 chr7:128404372(+) A-G intron -    22484847 chr7:128404421(+) A-G intron -    22484847 chr7:128404432(+) A-G intron -    22484847 chr7:128404467(+) A-G intron -    22484847 chr7:128405007(+) A-G intron -    22484847 chr7:128405048(+) A-G intron -    22484847 chr7:128405306(+) A-G intron -    22484847 chr7:128405354(+) A-G intron -    22484847 chr7:128406064(+) A-G intron -    22484847 chr7:128406199(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CALU	chr7:128379391-128379392(+) m6A 5'UTR       24981863 chr7:128387907-128387908(+) m6A 5'UTR//intron       24981863//22608085 chr7:128387949-128387950(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128387991-128387992(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128388048-128388049(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr7:128388062-128388063(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388106-128388107(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388126-128388127(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388164-128388165(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388184-128388185(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388229-128388230(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388234-128388235(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388280-128388281(+) m6A 5'UTR//intron       24981863//22608085 chr7:128388311-128388312(+) m6A 5'UTR//intron       22608085 chr7:128388359-128388360(+) m6A 5'UTR//intron       22608085 chr7:128388370-128388371(+) m6A 5'UTR//intron       22608085 chr7:128388696-128388697(+) m6A CDS       27773535 chr7:128388713-128388714(+) m6A CDS       27773535 chr7:128388814-128388815(+) m6A CDS       24981863//26404942//27773535 chr7:128394377-128394378(+) m6A CDS//intron       24981863//26404942//27773535 chr7:128394427-128394428(+) Cm CDS//intron       - chr7:128394692-128394693(+) m6A CDS//intron       27773535 chr7:128398958-128398959(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128398999-128399000(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399011-128399012(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399848-128399849(+) m6A CDS       24209618//24981863//26404942//27773535//22575960 chr7:128407559-128407560(+) m6A CDS//intron       24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407596-128407597(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407607-128407608(+) Am CDS//intron       - chr7:128407614-128407615(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407625-128407626(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407632-128407633(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407650-128407651(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407698-128407699(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407704-128407705(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409232-128409233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409303-128409304(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409316-128409317(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409326-128409327(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409347-128409348(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409382-128409383(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409409-128409410(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409544-128409545(+) m6A 3'UTR//intron       26404942//27773535 chr7:128409695-128409696(+) m6A 3'UTR//intron       27773535 chr7:128410044-128410045(+) Y 3'UTR//intron       25219674 chr7:128410416-128410417(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410464-128410465(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410520-128410521(+) Am 3'UTR//intron       - chr7:128410531-128410532(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410560-128410561(+) m6A 3'UTR//intron       24981863//26404942//27773535 chr7:128410714-128410715(+) m6A 3'UTR//intron       27773535 chr7:128410763-128410764(+) m6A 3'UTR//intron       27773535 chr7:128411136-128411137(+) m6A 3'UTR//intron       27773535 chr7:128411191-128411192(+) m6A 3'UTR//intron       27773535 chr7:128411248-128411249(+) Y 3'UTR//intron       26075521 chr7:128411272-128411273(+) m6A 3'UTR//intron       26404942 chr7:128411288-128411289(+) m6A 3'UTR//intron       26404942 chr7:128411377-128411378(+) m6A 3'UTR//intron       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-195-5p	Exosome Serum     18589210 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	CALU	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-195-5p	Succinimide, 3-chloro-N-(p-methoxyphenyl)- 99724 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant Acridine Yellow G 8672 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Deferoxamine hydrochloride 62880 Drug resistant 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 5459202 Drug resistant 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Amonafide 50515 Drug resistant Justicidin B 442882 Drug resistant Entinostat 4261 Drug resistant 5-Benzyl-9-hydroxy-5H-indeno[1,2-b]indol-10-one 406582 Drug sensitive Massoia lactone 39914 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant Miltefosine 3599 Drug resistant 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive Antineoplastic-92909 261046 Drug sensitive Spongiaquinone 23424796 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant Verrucarin A 9,10-epoxide 181390 Drug resistant Aklavin 149755 Drug resistant Perifosine 148177 Drug resistant Edelfosine 1392 Drug resistant Emofolin sodium 135475347 Drug resistant 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive Octadecylphosphocholine 125219 Drug resistant Pararosaniline hydrochloride 11292 Drug sensitive Erigerol 101318126 Drug resistant Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug resistant 1-o-benzoylcastanospermine - Drug resistant methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant xenorhabdin 1 - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 6-Chloro-5-[2-(piperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug sensitive 6-aryl alkyl fluoro quinolone derivative - Drug sensitive crotoxin cd - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-195-5p	Palmitic acid 985 Drug interaction    RC00003301 Curcumin 969516 Drug interaction    RC00003314 Benzothiazole 7222 Drug interaction    RC00003308 Gemcitabine 60750 Drug interaction    RC00003311 D-Glucose 5793 Drug interaction    RC00003307 Temozolomide 5394 Drug interaction    RC00003306 Eloxatine 5310940 Drug interaction    RC00003315 Imatinib 5291 Drug interaction    RC00003305 Diethylstilbestrol 448537 Drug interaction    RC00003313 Paclitaxel 36314 Drug interaction    RC00003310 5-Fluorouracil 3385 Drug interaction    RC00003304 Doxorubicin 31703 Drug interaction    RC00003309 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003303 Celecoxib 2662 Drug interaction    RC00003302 Docetaxel 148124 Drug interaction    RC00003312 platinum-based doublet chemotherapy - Drug interaction    RC00003316 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003317 Aidi injection - Drug interaction    RC00003318 Trastuzumab - Drug interaction    RC00003320 Glucocorticoid - Drug interaction    RC00003319

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-195-5p	Oxaliplatin 9887053       29956811 5-Fluorouracil 3385       29852230 5-Fluorouracil 3385       29956811 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-195-5p
Interactor2: CALU

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).