Detail Information

Basic Information:


  VIRBase ID:  

HHID00053521

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-193a-3p:           WDR82:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-193a-3p WDR82
miRBase
Accession/Entrez ID		 MIMAT0000459 80335
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MST107//MSTP107//PRO2730//PRO34047//SWD2//TMEM113//WDR82A

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-193a-3p
rs1400889170 chr17:31560070    G/A
rs751451706 chr17:31560061    A/C
rs751451706 chr17:31560061    A/G
rs763879010 chr17:31560059    A/C
rs767556858 chr17:31560062    A/C
rs767556858 chr17:31560062    A/G
rs1164644764 chr17:31560051    A/G
rs1317611558 chr17:31560056    C/T
rs1350982002 chr17:31560057    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR WDR82
chr3:52299310(-) A-I      intronic
chr3:52299188(-) A-I      intronic
chr3:52308836(-) A-I      intronic
chr3:52308976(-) A-I      intronic
chr3:52298872(-) A-I      intronic
chr3:52303007(-) A-I      intronic
chr3:52304354(-) A-I      intronic
chr3:52298840(-) A-I      intronic
chr3:52298837(-) A-I      intronic
chr3:52297062(-) A-I      intronic
chr3:52297061(-) A-I      intronic
chr3:52309075(-) A-I      intronic
chr3:52309137(-) A-I      intronic
chr3:52309174(-) A-I      intronic
chr3:52305938(-) A-I      intronic
chr3:52305988(-) A-I      intronic
chr3:52305981(-) A-I      intronic
chr3:52306558(-) A-I      intronic
chr3:52307220(-) A-I      intronic
chr3:52302991(-) A-I      intronic
chr3:52307866(-) A-I      intronic
chr3:52300649(-) A-I      intronic
chr3:52307905(-) A-I      intronic
chr3:52307823(-) A-I      intronic
chr3:52307805(-) A-I      intronic
chr3:52307713(-) A-I      intronic
chr3:52307704(-) A-I      intronic
chr3:52300657(-) A-I      intronic
chr3:52307339(-) A-I      intronic
chr3:52307243(-) A-I      intronic
chr3:52302905(-) A-I      intronic
chr3:52302939(-) A-I      intronic
chr3:52303025(-) A-I      intronic
chr3:52303058(-) A-I      intronic
chr3:52307919(-) A-I      intronic
chr3:52303081(-) A-I      intronic
chr3:52303299(-) A-I      intronic
chr3:52303311(-) A-I      intronic
chr3:52303382(-) A-I      intronic
chr3:52303616(-) A-I      intronic
chr3:52303699(-) A-I      intronic
chr3:52304273(-) A-I      intronic
chr3:52307910(-) A-I      intronic
chr3:52304300(-) A-I      intronic
chr3:52304315(-) A-I      intronic
chr3:52307911(-) A-I      intronic
chr3:52304331(-) A-I      intronic
chr3:52305888(-) A-I      intronic
chr3:52305958(-) A-I      intronic
chr3:52307352(-) A-I      intronic
chr3:52307814(-) A-I      intronic
chr3:52308411(-) A-I      intronic
chr3:52310325(-) A-I      intronic
chr3:52307815(-) A-I      intronic
chr3:52297110(-) A-I      intronic
chr3:52303732(-) A-I      intronic
chr3:52303013(-) A-I      intronic
chr3:52307338(-) A-I      intronic
chr3:52303001(-) A-I      intronic
chr3:52298841(-) A-I      intronic
chr3:52300627(-) A-I      intronic
chr3:52303024(-) A-I      intronic
chr3:52307411(-) A-I      intronic
chr3:52307702(-) A-I      intronic
chr3:52299168(-) A-I      intronic
chr3:52307722(-) A-I      intronic
chr3:52305949(-) A-I      intronic
chr3:52302946(-) A-I      intronic
chr3:52302952(-) A-I      intronic
chr3:52306023(-) A-I      intronic
chr3:52308381(-) A-I      intronic
chr3:52307734(-) A-I      intronic
chr3:52303027(-) A-I      intronic
chr3:52289065(-) A-I      3'UTR
chr3:52289055(-) A-I      3'UTR
chr3:52300743(-) A-I      intronic
chr3:52304318(-) A-I      intronic
chr3:52306006(-) A-I      intronic
chr3:52303663(-) A-I      intronic
chr3:52307802(-) A-I      intronic
chr3:52299269(-) A-I      intronic
chr3:52307733(-) A-I      intronic
chr3:52308654(-) A-I      intronic
chr3:52307856(-) A-I      intronic
chr3:52298883(-) A-I      intronic
chr3:52307811(-) A-I      intronic
chr3:52303104(-) A-I      intronic
chr3:52299865(-) A-I      intronic
chr3:52299204(-) A-I      intronic
chr3:52303588(-) A-I      intronic
chr3:52303008(-) A-I      intronic
chr3:52307762(-) A-I      intronic
chr3:52299730(-) A-I      intronic
chr3:52307347(-) A-I      intronic
chr3:52303659(-) A-I      intronic
chr3:52304423(-) A-I      intronic
chr3:52307917(-) A-I      intronic
chr3:52307855(-) A-I      intronic
chr3:52299149(-) A-I      intronic
chr3:52305966(-) A-I      intronic
chr3:52307776(-) A-I      intronic
chr3:52308835(-) A-I      intronic
chr3:52303063(-) A-I      intronic
chr3:52302889(-) A-I      intronic
chr3:52299688(-) A-I      intronic
chr3:52299864(-) A-I      intronic
chr3:52299158(-) A-I      intronic
chr3:52303004(-) A-I      intronic
chr3:52307858(-) A-I      intronic
chr3:52299075(-) A-I      intronic
chr3:52303582(-) A-I      intronic
chr3:52307786(-) A-I      intronic
chr3:52303683(-) A-I      intronic
chr3:52304329(-) A-I      intronic
chr3:52307742(-) A-I      intronic
chr3:52304409(-) A-I      intronic
chr3:52305865(-) A-I      intronic
chr3:52306529(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED WDR82
chr3:52305888(-) A-I intron -    21960545
chr3:52298841(-) A-G intron -    22484847
chr3:52299204(-) A-G intron -    22484847
chr3:52300627(-) A-G intron -    22484847
chr3:52300733(-) A-G intron -    22484847
chr3:52300743(-) A-G intron -    22484847
chr3:52302946(-) A-G intron -    22484847
chr3:52302984(-) A-G intron -    22484847
chr3:52303001(-) A-G intron -    22484847
chr3:52303013(-) A-G intron -    22484847
chr3:52303063(-) A-G intron -    22484847
chr3:52303582(-) A-G intron -    22484847
chr3:52303588(-) A-G intron -    22484847
chr3:52303634(-) A-G intron -    22484847
chr3:52303646(-) A-G intron -    22484847
chr3:52303663(-) A-G intron -    22484847
chr3:52303683(-) A-G intron -    22484847
chr3:52303694(-) A-G intron -    22484847
chr3:52303732(-) A-G intron -    22484847
chr3:52303740(-) A-G intron -    22484847
chr3:52304423(-) A-G intron -    22484847
chr3:52305949(-) A-G intron -    22484847
chr3:52306006(-) A-G intron -    22484847
chr3:52306023(-) A-G intron -    22484847
chr3:52307338(-) A-G intron -    22484847
chr3:52307347(-) A-G intron -    22484847
chr3:52307352(-) A-G intron -    22484847
chr3:52307722(-) A-G intron -    22484847
chr3:52307734(-) A-G intron -    22484847
chr3:52307762(-) A-G intron -    22484847
chr3:52307776(-) A-G intron -    22484847
chr3:52307786(-) A-G intron -    22484847
chr3:52307811(-) A-G intron -    22484847
chr3:52307813(-) A-G intron -    22484847
chr3:52307814(-) A-G intron -    22484847
chr3:52307815(-) A-G intron -    22484847
chr3:52307855(-) A-G intron -    22484847
chr3:52307856(-) A-G intron -    22484847
chr3:52307857(-) A-G intron -    22484847
chr3:52307858(-) A-G intron -    22484847
chr3:52307917(-) A-G intron -    22484847
chr3:52308835(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase WDR82
chr3:52288984-52288985(-) m6A 3'UTR//exon       24284625//24209618
chr3:52289054-52289055(-) m6A 3'UTR//exon       24209618
chr3:52289150-52289151(-) m6A 3'UTR//exon       24209618
chr3:52290832-52290833(-) m6A 3'UTR//exon       24981863//27773535
chr3:52290932-52290933(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr3:52290946-52290947(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr3:52290979-52290980(-) m6A 3'UTR//exon       24284625//24209618//27773535
chr3:52290991-52290992(-) m6A 3'UTR//exon       24284625//27773535
chr3:52291235-52291236(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291287-52291288(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291298-52291299(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291314-52291315(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291398-52291399(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291441-52291442(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52291452-52291453(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:52292623-52292624(-) m6A CDS//exon       24284625//24209618//22608085
chr3:52312312-52312313(-) m6A 5'UTR//CDS//intron       27371828//22575960
chr3:52312318-52312319(-) m6A 5'UTR//CDS//intron       27371828//22575960
chr3:52312527-52312528(-) m1A 5'UTR//intron       26863196//26863410
chr3:52312547-52312548(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr3:52312632-52312633(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr3:52318594-52318595(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-193a-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     28246603
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     24683445
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
WDR82
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-193a-3p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug resistant
Ethyl phenylpropiolate 91516 Drug resistant
Acridine Yellow G 8672 Drug resistant
Cinerubin B 73593 Drug resistant
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug resistant
Morpholine-N-dithiocarbamate 72675 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
(2S)-N-[(E,2S,4S,7S)-7-[[(2R)-2-Aminopropanoyl]amino]-4-formyl-5-(3-hydroxy-4-methoxyphenyl)-2-[[(Z)-3-(4-methoxyphenyl)-2-(methylamino)prop-2-enoyl]amino]-3,6,10-trioxodec-8-en-4-yl]-3-(4-hydroxyphenyl)-N-methyl-2-(methylamino)propanamide 6444175 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Cuspidatin C 5459164 Drug resistant
Thiram 5455 Drug resistant
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug resistant
N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant
Tiazofurin 457954 Drug resistant
Physalolactone 433866 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
Rogiolol 402519 Drug resistant
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug resistant
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
N-Hydroxy-N-methylpropanethioamide 371713 Drug resistant
Discorhabdin C . TFA 362393 Drug resistant
3-Deazaneplanocin hydrochloride 358176 Drug resistant
4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug resistant
Predorine 333830 Drug resistant
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
Erigerol 101318126 Drug resistant
[(1R,2S,4R,6R,7S,9S,11S,12S)-11-Hydroxy-4-methyl-10,15-dimethylidene-14-oxo-5,8,13-trioxatetracyclo[10.3.0.04,6.07,9]pentadecan-2-yl] (Z)-2-methylbut-2-enoate 101316721 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
1-piperidinecarbodithioic acid, antimony complex - Drug resistant
2-propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl- (9ci) - Drug resistant
3,19-(4-n,n-dimethylamino)benzylidineandrographolide - Drug resistant
3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug resistant
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug resistant
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
ellipticine, 6-(3-aminopropyl)-, dihydrochloride - Drug resistant
ellipticine, 6-(3-aminopropyl)-9-methoxy-, dihydrochloride - Drug resistant
phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug resistant
7-propanoyltaxol - Drug resistant
dichlorobisoxinatotitanium(iv) - Drug resistant
euchrysine - Drug resistant
maleimide carbazole - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
pneumocandin b(sub 0) - Drug resistant
Uniroyal Compound-38 - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-193a-3p
Epirubicin hydrochloride 65348 Drug interaction    RC00003267
Theprubicin 636397 Drug interaction    RC00003273
Gemcitabine 60750 Drug interaction    RC00003266
Prednisone 5865 Drug interaction    RC00003261
Temozolomide 5394 Drug interaction    RC00003260
Sunitinib 5329102 Drug interaction    RC00003276
Eloxatine 5310940 Drug interaction    RC00003275
Decitabine 451668 Drug interaction    RC00003272
Trichostatin A 444732 Drug interaction    RC00003271
Paroxetine 43815 Drug interaction    RC00003265
Paclitaxel 36314 Drug interaction    RC00003264
5-Fluorouracil 3385 Drug interaction    RC00003259
Enoxacin 3229 Drug interaction    RC00003258
Doxorubicin 31703 Drug interaction    RC00003263
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003257
Tamoxifen 2733526 Drug interaction    RC00003274
Verapamil 2520 Drug interaction    RC00003256
Navitoclax 24978538 Drug interaction    RC00003277
Lenalidomide 216326 Drug interaction    RC00003270
Sorafenib 216239 Drug interaction    RC00003269
Ginsenoside Rh2 119307 Drug interaction    RC00003268
Androstanolone 10635 Drug interaction    RC00003262
platinum-based doublet chemotherapy - Drug interaction    RC00003278
SIOP treatment protocol - Drug interaction    RC00003279
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00003280
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00003281
Chemotherapy - Drug interaction    RC00008848
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-193a-3p
KW-2307 base 71296871       26743123
Cisplatin 5702198       25542424
Cisplatin 5702198       30485589
(7S,9S)-7-[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydron;chloride 53630345       25542424
Paclitaxel 36314       25188512
Paclitaxel 36314       25311867
Paclitaxel 36314       25444900
Paclitaxel 36314       25542424
Paclitaxel 36314       26743123
5-Fluorouracil 3385       22117060
5-Fluorouracil 3385       26743123
Doxorubicin 31703       25542424
Docetaxel 148124       26743123
(9S)-7-[(2R)-4-Amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 137704806       25542424

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-193a-3p
Interactor2: WDR82

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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