Detail Information

Basic Information:


  VIRBase ID:  

HHID00053484

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           TP53INP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p TP53INP1
miRBase
Accession/Entrez ID		 MIMAT0000458 94241
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - p53DINP1//SIP//Teap//TP53DINP1//TP53INP1A//TP53INP1B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TP53INP1
chr8:95951793(-) A-I      intronic
chr8:95945881(-) A-I      intronic
chr8:95945830(-) A-I      intronic
chr8:95945810(-) A-I      intronic
chr8:95945801(-) A-I      intronic
chr8:95951844(-) A-I      intronic
chr8:95949561(-) A-I      intronic
chr8:95949560(-) A-I      intronic
chr8:95949547(-) A-I      intronic
chr8:95951853(-) A-I      intronic
chr8:95951829(-) A-I      intronic
chr8:95951827(-) A-I      intronic
chr8:95946881(-) A-I      intronic
chr8:95946875(-) A-I      intronic
chr8:95946829(-) A-I      intronic
chr8:95945311(-) A-I      intronic
chr8:95945277(-) A-I      intronic
chr8:95946828(-) A-I      intronic
chr8:95944968(-) A-I      intronic
chr8:95946806(-) A-I      intronic
chr8:95946798(-) A-I      intronic
chr8:95946793(-) A-I      intronic
chr8:95946676(-) A-I      intronic
chr8:95946648(-) A-I      intronic
chr8:95946644(-) A-I      intronic
chr8:95945941(-) A-I      intronic
chr8:95945930(-) A-I      intronic
chr8:95945893(-) A-I      intronic
chr8:95944949(-) A-I      intronic
chr8:95944883(-) A-I      intronic
chr8:95951921(-) A-I      intronic
chr8:95951907(-) A-I      intronic
chr8:95951788(-) A-I      intronic
chr8:95951770(-) A-I      intronic
chr8:95951732(-) A-I      intronic
chr8:95944842(-) A-I      intronic
chr8:95944131(-) A-I      intronic
chr8:95944117(-) A-I      intronic
chr8:95951721(-) A-I      intronic
chr8:95944078(-) A-I      intronic
chr8:95943977(-) A-I      intronic
chr8:95951792(-) A-I      intronic
chr8:95951791(-) A-I      intronic
chr8:95943968(-) A-I      intronic
chr8:95951710(-) A-I      intronic
chr8:95951693(-) A-I      intronic
chr8:95951655(-) A-I      intronic
chr8:95943958(-) A-I      intronic
chr8:95944984(-) A-I      intronic
chr8:95945790(-) A-I      intronic
chr8:95949472(-) A-I      intronic
chr8:95946826(-) A-I      intronic
chr8:95946903(-) A-I      intronic
chr8:95951717(-) A-I      intronic
chr8:95944931(-) A-I      intronic
chr8:95945821(-) A-I      intronic
chr8:95951748(-) A-I      intronic
chr8:95945869(-) A-I      intronic
chr8:95951762(-) A-I      intronic
chr8:95951692(-) A-I      intronic
chr8:95945730(-) A-I      intronic
chr8:95944092(-) A-I      intronic
chr8:95944186(-) A-I      intronic
chr8:95945910(-) A-I      intronic
chr8:95951845(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TP53INP1
chr8:95938484-95938485(-) m6A 3'UTR       24981863//27773535
chr8:95938553-95938554(-) m6A 3'UTR       27773535
chr8:95938570-95938571(-) m6A 3'UTR       27773535
chr8:95938609-95938610(-) m6A 3'UTR       27773535
chr8:95938679-95938680(-) m6A 3'UTR       24209618//27773535
chr8:95938763-95938764(-) m6A 3'UTR       27773535
chr8:95938768-95938769(-) m6A 3'UTR       27773535
chr8:95938778-95938779(-) m6A 3'UTR       27773535
chr8:95942826-95942827(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr8:95942838-95942839(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr8:95942877-95942878(-) m6A 3'UTR//CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr8:95944311-95944312(-) m6A 3'UTR//intron       24209618//24981863//27773535//27371828//22608085
chr8:95952118-95952119(-) m6A CDS       24209618//24981863//27773535//22608085
chr8:95952185-95952186(-) m6A CDS       24981863//27773535//22608085
chr8:95952198-95952199(-) m6A CDS       24981863//27773535//22608085
chr8:95952214-95952215(-) m6A CDS       24981863//27773535//22608085
chr8:95952402-95952403(-) m6A CDS       27773535//27371828
chr8:95953109-95953110(-) m6A CDS       27371828
chr8:95953189-95953190(-) m6A 5'UTR       24981863//22608085
chr8:95953201-95953202(-) m6A 5'UTR       24981863//22608085
chr8:95953230-95953231(-) m6A 5'UTR       24981863//22608085
chr8:95961571-95961572(-) m6A 5'UTR       25456834//24981863//27371828//27773536
chr8:95961577-95961578(-) m6A 5'UTR       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
TP53INP1
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: TP53INP1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 25086243 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//Akata cells//Raji cells//Sav I cells Interactor2 expression Upregulation
Description By targeting TP53INP1, miR-190 enhances cell survival by preventing apoptosis and relieving G0/G1 cell cycle arrest. Additionally, miR-190 down-regulates NR4A3, a cellular immediate-early gene for EBV reactivation, and inhibits the expression of the viral immediate-early gene bzlf1 and viral lytic DNA replication.

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