Basic Information:

  VIRBase ID:  

HHID00053479

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          DDX50:  NM_024045     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	DDX50
miRBase Accession/Entrez ID	MIMAT0000458	79009
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GU2//GUB//mcdrh//RH-II/GuB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX50	chr10:70676526(+) A-I      intronic chr10:70683106(+) A-I      intronic chr10:70683079(+) A-I      intronic chr10:70680526(+) A-I      intronic chr10:70676520(+) A-I      intronic chr10:70680500(+) A-I      intronic chr10:70680506(+) A-I      intronic chr10:70683149(+) A-I      intronic chr10:70692173(+) A-I      intronic chr10:70700311(+) A-I      intronic chr10:70680128(+) A-I      intronic chr10:70668031(+) A-I      intronic chr10:70692117(+) A-I      intronic chr10:70679968(+) A-I      intronic chr10:70679937(+) A-I      intronic chr10:70678466(+) A-I      intronic chr10:70686736(+) A-I      intronic chr10:70678444(+) A-I      intronic chr10:70676642(+) A-I      intronic chr10:70680594(+) A-I      intronic chr10:70687928(+) A-I      intronic chr10:70680626(+) A-I      intronic chr10:70678459(+) A-I      intronic chr10:70678417(+) A-I      intronic chr10:70678392(+) A-I      intronic chr10:70678309(+) A-I      intronic chr10:70678266(+) A-I      intronic chr10:70677621(+) A-I      intronic chr10:70682709(+) A-I      intronic chr10:70680607(+) A-I      intronic chr10:70677495(+) A-I      intronic chr10:70677459(+) A-I      intronic chr10:70677085(+) A-I      intronic chr10:70677073(+) A-I      intronic chr10:70680123(+) A-I      intronic chr10:70677006(+) A-I      intronic chr10:70676582(+) A-I      intronic chr10:70676580(+) A-I      intronic chr10:70685420(+) A-I      intronic chr10:70676570(+) A-I      intronic chr10:70665565(+) A-I      intronic chr10:70687843(+) A-I      intronic chr10:70688245(+) A-I      intronic chr10:70676558(+) A-I      intronic chr10:70676512(+) A-I      intronic chr10:70700105(+) A-I      intronic chr10:70685854(+) A-I      intronic chr10:70687992(+) A-I      intronic chr10:70693544(+) A-I      intronic chr10:70700085(+) A-I      intronic chr10:70682491(+) A-I      intronic chr10:70693531(+) A-I      intronic chr10:70700206(+) A-I      intronic chr10:70700436(+) A-I      intronic chr10:70693530(+) A-I      intronic chr10:70700215(+) A-I      intronic chr10:70700395(+) A-I      intronic chr10:70669914(+) A-I      intronic chr10:70693435(+) A-I      intronic chr10:70693023(+) A-I      intronic chr10:70680030(+) A-I      intronic chr10:70692199(+) A-I      intronic chr10:70669761(+) A-I      intronic chr10:70669496(+) A-I      intronic chr10:70692116(+) A-I      intronic chr10:70700062(+) A-I      intronic chr10:70691415(+) A-I      intronic chr10:70692064(+) A-I      intronic chr10:70691330(+) A-I      intronic chr10:70691326(+) A-I      intronic chr10:70691086(+) A-I      intronic chr10:70690669(+) A-I      intronic chr10:70690648(+) A-I      intronic chr10:70682428(+) A-I      intronic chr10:70690029(+) A-I      intronic chr10:70689927(+) A-I      intronic chr10:70688822(+) A-I      intronic chr10:70695619(+) A-I      intronic chr10:70688760(+) A-I      intronic chr10:70688227(+) A-I      intronic chr10:70688193(+) A-I      intronic chr10:70687906(+) A-I      intronic chr10:70687671(+) A-I      intronic chr10:70687658(+) A-I      intronic chr10:70686857(+) A-I      intronic chr10:70686835(+) A-I      intronic chr10:70686810(+) A-I      intronic chr10:70686781(+) A-I      intronic chr10:70686411(+) A-I      intronic chr10:70668684(+) A-I      intronic chr10:70685702(+) A-I      intronic chr10:70685627(+) A-I      intronic chr10:70668676(+) A-I      intronic chr10:70668510(+) A-I      intronic chr10:70685618(+) A-I      intronic chr10:70685594(+) A-I      intronic chr10:70685584(+) A-I      intronic chr10:70685563(+) A-I      intronic chr10:70668497(+) A-I      intronic chr10:70662883(+) A-I      intronic chr10:70685499(+) A-I      intronic chr10:70685404(+) A-I      intronic chr10:70685049(+) A-I      intronic chr10:70682608(+) A-I      intronic chr10:70685046(+) A-I      intronic chr10:70685005(+) A-I      intronic chr10:70684960(+) A-I      intronic chr10:70684959(+) A-I      intronic chr10:70691428(+) A-I      intronic chr10:70700240(+) A-I      intronic chr10:70684155(+) A-I      intronic chr10:70675843(+) A-I      intronic chr10:70683562(+) A-I      intronic chr10:70683535(+) A-I      intronic chr10:70683534(+) A-I      intronic chr10:70683447(+) A-I      intronic chr10:70683441(+) A-I      intronic chr10:70683439(+) A-I      intronic chr10:70683361(+) A-I      intronic chr10:70699943(+) A-I      intronic chr10:70700250(+) A-I      intronic chr10:70683393(+) A-I      intronic chr10:70680581(+) A-I      intronic chr10:70683360(+) A-I      intronic chr10:70683244(+) A-I      intronic chr10:70683236(+) A-I      intronic chr10:70693009(+) A-I      intronic chr10:70683184(+) A-I      intronic chr10:70683046(+) A-I      intronic chr10:70683028(+) A-I      intronic chr10:70682767(+) A-I      intronic chr10:70682749(+) A-I      intronic chr10:70682747(+) A-I      intronic chr10:70685643(+) A-I      intronic chr10:70682744(+) A-I      intronic chr10:70682687(+) A-I      intronic chr10:70693554(+) A-I      intronic chr10:70693570(+) A-I      intronic chr10:70700014(+) A-I      intronic chr10:70682406(+) A-I      intronic chr10:70682402(+) A-I      intronic chr10:70675296(+) A-I      intronic chr10:70682398(+) A-I      intronic chr10:70678445(+) A-I      intronic chr10:70682371(+) A-I      intronic chr10:70682363(+) A-I      intronic chr10:70677498(+) A-I      intronic chr10:70682289(+) A-I      intronic chr10:70680586(+) A-I      intronic chr10:70680555(+) A-I      intronic chr10:70680667(+) A-I      intronic chr10:70680551(+) A-I      intronic chr10:70700448(+) A-I      intronic chr10:70700069(+) A-I      intronic chr10:70687944(+) A-I      intronic chr10:70683729(+) A-I      intronic chr10:70674915(+) A-I      intronic chr10:70702482(+) A-I      intronic chr10:70685374(+) A-I      intronic chr10:70680531(+) A-I      intronic chr10:70668060(+) A-I      intronic chr10:70680518(+) A-I      intronic chr10:70680501(+) A-I      intronic chr10:70682367(+) A-I      intronic chr10:70675307(+) A-I      intronic chr10:70680492(+) A-I      intronic chr10:70683561(+) A-I      intronic chr10:70677121(+) A-I      intronic chr10:70680463(+) A-I      intronic chr10:70680154(+) A-I      intronic chr10:70685711(+) A-I      intronic chr10:70705298(+) A-I      intronic chr10:70679941(+) A-I      intronic chr10:70693426(+) A-I      intronic chr10:70678215(+) A-I      intronic chr10:70690555(+) A-I      intronic chr10:70703525(+) A-I      intronic chr10:70700284(+) A-I      intronic chr10:70700183(+) A-I      intronic chr10:70685410(+) A-I      intronic chr10:70685128(+) A-I      intronic chr10:70668796(+) A-I      intronic chr10:70687964(+) A-I      intronic chr10:70682488(+) A-I      intronic chr10:70683483(+) A-I      intronic chr10:70677034(+) A-I      intronic chr10:70692251(+) A-I      intronic chr10:70676991(+) A-I      intronic chr10:70665510(+) A-I      intronic chr10:70678380(+) A-I      intronic chr10:70700095(+) A-I      intronic chr10:70664881(+) A-I      intronic chr10:70675373(+) A-I      intronic chr10:70664963(+) A-I      intronic chr10:70686406(+) A-I      intronic chr10:70664957(+) A-I      intronic chr10:70683165(+) A-I      intronic chr10:70684986(+) A-I      intronic chr10:70680035(+) A-I      intronic chr10:70678256(+) A-I      intronic chr10:70683101(+) A-I      intronic chr10:70680047(+) A-I      intronic chr10:70692133(+) A-I      intronic chr10:70693100(+) A-I      intronic chr10:70677069(+) A-I      intronic chr10:70693515(+) A-I      intronic chr10:70675421(+) A-I      intronic chr10:70678405(+) A-I      intronic chr10:70687781(+) A-I      intronic chr10:70680613(+) A-I      intronic chr10:70686700(+) A-I      intronic chr10:70683335(+) A-I      intronic chr10:70700063(+) A-I      intronic chr10:70682296(+) A-I      intronic chr10:70669441(+) A-I      intronic chr10:70685803(+) A-I      intronic chr10:70699916(+) A-I      intronic chr10:70700123(+) A-I      intronic chr10:70674953(+) A-I      intronic chr10:70678292(+) A-I      intronic chr10:70700045(+) A-I      intronic chr10:70686762(+) A-I      intronic chr10:70688883(+) A-I      intronic chr10:70680516(+) A-I      intronic chr10:70693529(+) A-I      intronic chr10:70675422(+) A-I      intronic chr10:70682384(+) A-I      intronic chr10:70676509(+) A-I      intronic chr10:70688194(+) A-I      intronic chr10:70693490(+) A-I      intronic chr10:70690682(+) A-I      intronic chr10:70692196(+) A-I      intronic chr10:70683417(+) A-I      intronic chr10:70668637(+) A-I      intronic chr10:70699913(+) A-I      intronic chr10:70693492(+) A-I      intronic chr10:70680108(+) A-I      intronic chr10:70690112(+) A-I      intronic chr10:70665448(+) A-I      intronic chr10:70686719(+) A-I      intronic chr10:70683132(+) A-I      intronic chr10:70668087(+) A-I      intronic chr10:70680603(+) A-I      intronic chr10:70687960(+) A-I      intronic chr10:70684916(+) A-I      intronic chr10:70665517(+) A-I      intronic chr10:70687702(+) A-I      intronic chr10:70700080(+) A-I      intronic chr10:70676677(+) A-I      intronic chr10:70703265(+) A-I      intronic chr10:70700106(+) A-I      intronic chr10:70680602(+) A-I      intronic chr10:70688011(+) A-I      intronic chr10:70682370(+) A-I      intronic chr10:70696476(+) A-I      intronic chr10:70664906(+) A-I      intronic chr10:70704372(+) A-I      intronic chr10:70683424(+) A-I      intronic chr10:70692047(+) A-I      intronic chr10:70685448(+) A-I      intronic chr10:70685375(+) A-I      intronic chr10:70664956(+) A-I      intronic chr10:70669360(+) A-I      intronic chr10:70680057(+) A-I      intronic chr10:70690136(+) A-I      intronic chr10:70688172(+) A-I      intronic chr10:70677445(+) A-I      intronic chr10:70675003(+) A-I      intronic chr10:70664812(+) A-I      intronic chr10:70682434(+) A-I      intronic chr10:70665404(+) A-I      intronic chr10:70678383(+) A-I      intronic chr10:70677963(+) A-I      intronic chr10:70677602(+) A-I      intronic chr10:70700060(+) A-I      intronic chr10:70700394(+) A-I      intronic chr10:70676958(+) A-I      intronic chr10:70688171(+) A-I      intronic chr10:70692096(+) A-I      intronic chr10:70672021(+) A-I      intronic chr10:70686834(+) A-I      intronic chr10:70668663(+) A-I      intronic chr10:70701561(+) A-I      intronic chr10:70683067(+) A-I      intronic chr10:70682287(+) A-I      intronic chr10:70692134(+) A-I      intronic chr10:70687834(+) A-I      intronic chr10:70680552(+) A-I      intronic chr10:70690444(+) A-I      intronic chr10:70680433(+) A-I      intronic chr10:70675958(+) A-I      intronic chr10:70677706(+) A-I      intronic chr10:70690522(+) A-I      intronic chr10:70677573(+) A-I      intronic chr10:70682580(+) A-I      intronic chr10:70687719(+) A-I      intronic chr10:70686842(+) A-I      intronic chr10:70685482(+) A-I      intronic chr10:70692954(+) A-I      intronic chr10:70700409(+) A-I      intronic chr10:70691424(+) A-I      intronic chr10:70680017(+) A-I      intronic chr10:70693535(+) A-I      intronic chr10:70699944(+) A-I      intronic chr10:70690148(+) A-I      intronic chr10:70676496(+) A-I      intronic chr10:70687997(+) A-I      intronic chr10:70685841(+) A-I      intronic chr10:70665484(+) A-I      intronic chr10:70664920(+) A-I      intronic chr10:70686786(+) A-I      intronic chr10:70678363(+) A-I      intronic chr10:70677140(+) A-I      intronic chr10:70675351(+) A-I      intronic chr10:70680109(+) A-I      intronic chr10:70700293(+) A-I      intronic chr10:70699890(+) A-I      intronic chr10:70680185(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DDX50	chr10:70700394(+) A-I intron -    22327324 chr10:70686405(+) A-I intron -    21960545 chr10:70664881(+) A-G intron -    22484847 chr10:70664961(+) C-G intron -    22484847 chr10:70665484(+) A-G intron -    22484847 chr10:70668087(+) A-G intron -    22484847 chr10:70675422(+) A-G intron -    22484847 chr10:70680602(+) A-G intron -    22484847 chr10:70680603(+) A-G intron -    22484847 chr10:70685374(+) A-G intron -    22484847 chr10:70685375(+) A-G intron -    22484847 chr10:70699916(+) A-G intron -    22484847 chr10:70699943(+) A-G intron -    22484847 chr10:70700293(+) A-G intron -    22484847 chr10:70700394(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX50	chr10:70661151-70661152(+) m6A CDS       24209618//24981863 chr10:70661165-70661166(+) m6A CDS       24209618//24981863 chr10:70661212-70661213(+) m1A CDS       26863196 chr10:70666020-70666021(+) m6A CDS//intron       24209618//24981863 chr10:70666058-70666059(+) m6A 3'UTR//CDS//intron       24209618//27773535//22608085 chr10:70666074-70666075(+) m6A 3'UTR//intron       24209618//27773535//22608085 chr10:70666517-70666518(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr10:70666596-70666597(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr10:70666618-70666619(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr10:70666753-70666754(+) m6A 3'UTR//CDS       22608085 chr10:70679689-70679690(+) m6A CDS//exon       27773535 chr10:70706280-70706281(+) m6A CDS//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	DDX50	Chromatin K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: DDX50

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.