Detail Information

Basic Information:


  VIRBase ID:  

HHID00053477

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           RFK:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p RFK
miRBase
Accession/Entrez ID		 MIMAT0000458 55312
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RIFK

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RFK
chr9:79002681(-) A-I      ncRNA
chr9:79007717(-) A-I      intronic
chr9:79007798(-) A-I      intronic
chr9:79001882(-) A-I      3'UTR
chr9:79001890(-) A-I      3'UTR
chr9:79001891(-) A-I      3'UTR
chr9:79007636(-) A-I      intronic
chr9:79007566(-) A-I      intronic
chr9:79007572(-) A-I      intronic
chr9:79008350(-) A-I      intronic
chr9:79008336(-) A-I      intronic
chr9:79007814(-) A-I      intronic
chr9:79006772(-) A-I      intronic
chr9:79005498(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RFK
chr9:79001092-79001093(-) Y 3'UTR       25219674
chr9:79001295-79001296(-) m6A 3'UTR       26404942
chr9:79009094-79009095(-) m6A 5'UTR//exon       27773536
chr9:79009122-79009123(-) m6A 5'UTR//exon       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
RFK
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: RFK

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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