Detail Information

Basic Information:


  VIRBase ID:  

HHID00053472

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           MED4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p MED4
miRBase
Accession/Entrez ID		 MIMAT0000458 29079
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ARC36//DRIP36//HSPC126//TRAP36//VDRIP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MED4
chr13:48658217(-) A-I      intronic
chr13:48659172(-) A-I      intronic
chr13:48658151(-) A-I      intronic
chr13:48658234(-) A-I      intronic
chr13:48651833(-) A-I      intronic
chr13:48653684(-) A-I      intronic
chr13:48653764(-) A-I      intronic
chr13:48658229(-) A-I      intronic
chr13:48658284(-) A-I      intronic
chr13:48653793(-) A-I      intronic
chr13:48653800(-) A-I      intronic
chr13:48653862(-) A-I      intronic
chr13:48658333(-) A-I      intronic
chr13:48659476(-) A-I      intronic
chr13:48659413(-) A-I      intronic
chr13:48666427(-) A-I      intronic
chr13:48653713(-) A-I      intronic
chr13:48651640(-) A-I      intronic
chr13:48659594(-) A-I      intronic
chr13:48659176(-) A-I      intronic
chr13:48653620(-) A-I      intronic
chr13:48651672(-) A-I      intronic
chr13:48653794(-) A-I      intronic
chr13:48651819(-) A-I      intronic
chr13:48651774(-) A-I      intronic
chr13:48653754(-) A-I      intronic
chr13:48651820(-) A-I      intronic
chr13:48651706(-) A-I      intronic
chr13:48658140(-) A-I      intronic
chr13:48659436(-) A-I      intronic
chr13:48653861(-) A-I      intronic
chr13:48659600(-) A-I      intronic
chr13:48659599(-) A-I      intronic
chr13:48659099(-) A-I      intronic
chr13:48666311(-) A-I      intronic
chr13:48659100(-) A-I      intronic
chr13:48658205(-) A-I      intronic
chr13:48659114(-) A-I      intronic
chr13:48659260(-) A-I      intronic
chr13:48659179(-) A-I      intronic
chr13:48660907(-) A-I      intronic
chr13:48658288(-) A-I      intronic
chr13:48659479(-) A-I      intronic
chr13:48659432(-) A-I      intronic
chr13:48659184(-) A-I      intronic
chr13:48659508(-) A-I      intronic
chr13:48666369(-) A-I      intronic
chr13:48659482(-) A-I      intronic
chr13:48666520(-) A-I      intronic
chr13:48663855(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MED4
chr13:48657534-48657535(-) m6A CDS       24981863//27773535
chr13:48660426-48660427(-) m6A CDS       24981863//27773535
chr13:48660444-48660445(-) m6A CDS       24981863//27773535//22575960
chr13:48660469-48660470(-) m6A CDS       24981863//27773535//22575960
chr13:48660546-48660547(-) m6A CDS       24981863//27773535
chr13:48664491-48664492(-) m6A CDS       24209618//27773535
chr13:48664521-48664522(-) m6A CDS       24209618//27773535
chr13:48664550-48664551(-) m6A 5'UTR//CDS       24209618//27773535
chr13:48667754-48667755(-) m6A 5'UTR//intron       24209618
chr13:48669107-48669108(-) m6A 5'UTR//CDS//intron       25456834
chr13:48669225-48669226(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
MED4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: MED4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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