Basic Information:

  VIRBase ID:  

HHID00053462

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          STAMBP:  NR_148668     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	STAMBP
miRBase Accession/Entrez ID	MIMAT0000458	10617
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AMSH//MICCAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STAMBP	chr2:74076586(+) A-I      NonSyn:Glu->Gly chr2:74070472(+) A-I      intronic chr2:74080799(+) A-I      intronic chr2:74076617(+) A-I      intronic chr2:74076619(+) A-I      intronic chr2:74076620(+) A-I      intronic chr2:74070474(+) A-I      intronic chr2:74081732(+) A-I      intronic chr2:74070486(+) A-I      intronic chr2:74081737(+) A-I      intronic chr2:74070468(+) A-I      intronic chr2:74081739(+) A-I      intronic chr2:74073657(+) A-I      intronic chr2:74070657(+) A-I      intronic chr2:74070631(+) A-I      intronic chr2:74070593(+) A-I      intronic chr2:74070586(+) A-I      intronic chr2:74088884(+) A-I      intronic chr2:74073474(+) A-I      intronic chr2:74085400(+) A-I      intronic chr2:74072969(+) A-I      intronic chr2:74082073(+) A-I      intronic chr2:74082022(+) A-I      intronic chr2:74070583(+) A-I      intronic chr2:74062572(+) A-I      intronic chr2:74061259(+) A-I      intronic chr2:74061076(+) A-I      intronic chr2:74061066(+) A-I      intronic chr2:74078823(+) A-I      intronic chr2:74080673(+) A-I      intronic chr2:74078797(+) A-I      intronic chr2:74072790(+) A-I      intronic chr2:74080672(+) A-I      intronic chr2:74080728(+) A-I      intronic chr2:74080743(+) A-I      intronic chr2:74080770(+) A-I      intronic chr2:74080794(+) A-I      intronic chr2:74081702(+) A-I      intronic chr2:74082005(+) A-I      intronic chr2:74080665(+) A-I      intronic chr2:74080642(+) A-I      intronic chr2:74078896(+) A-I      intronic chr2:74078812(+) A-I      intronic chr2:74082001(+) A-I      intronic chr2:74072956(+) A-I      intronic chr2:74072942(+) A-I      intronic chr2:74072939(+) A-I      intronic chr2:74072839(+) A-I      intronic chr2:74072814(+) A-I      intronic chr2:74072863(+) A-I      intronic chr2:74088747(+) A-I      intronic chr2:74078879(+) A-I      intronic chr2:74082036(+) A-I      intronic chr2:74089144(+) A-I      intronic chr2:74081623(+) A-I      intronic chr2:74080639(+) A-I      intronic chr2:74089165(+) A-I      intronic chr2:74080837(+) A-I      intronic chr2:74073668(+) A-I      intronic chr2:74089125(+) A-I      intronic chr2:74081745(+) A-I      intronic chr2:74073716(+) A-I      intronic chr2:74081720(+) A-I      intronic chr2:74064458(+) A-I      intronic chr2:74082120(+) A-I      intronic chr2:74080702(+) A-I      intronic chr2:74079898(+) A-I      intronic chr2:74089007(+) A-I      intronic chr2:74067750(+) A-I      intronic chr2:74081603(+) A-I      intronic chr2:74081742(+) A-I      intronic chr2:74070454(+) A-I      intronic chr2:74085486(+) A-I      intronic chr2:74081703(+) A-I      intronic chr2:74061218(+) A-I      intronic chr2:74067760(+) A-I      intronic chr2:74079934(+) A-I      intronic chr2:74080617(+) A-I      intronic chr2:74080855(+) A-I      intronic chr2:74064738(+) A-I      intronic chr2:74088746(+) A-I      intronic chr2:74072979(+) A-I      intronic chr2:74089009(+) A-I      intronic chr2:74062550(+) A-I      intronic chr2:74081736(+) A-I      intronic chr2:74085249(+) A-I      intronic chr2:74080588(+) A-I      intronic chr2:74080738(+) A-I      intronic chr2:74073718(+) A-I      intronic chr2:74070670(+) A-I      intronic chr2:74082061(+) A-I      intronic chr2:74072858(+) A-I      intronic chr2:74085338(+) A-I      intronic chr2:74080010(+) A-I      intronic chr2:74061082(+) A-I      intronic chr2:74085549(+) A-I      intronic chr2:74080775(+) A-I      intronic chr2:74089075(+) A-I      intronic chr2:74081680(+) A-I      intronic chr2:74082026(+) A-I      intronic chr2:74089192(+) A-I      intronic chr2:74067737(+) A-I      intronic chr2:74081597(+) A-I      intronic chr2:74073741(+) A-I      intronic chr2:74088785(+) A-I      intronic chr2:74082071(+) A-I      intronic chr2:74089064(+) A-I      intronic chr2:74062229(+) A-I      intronic chr2:74080663(+) A-I      intronic chr2:74080755(+) A-I      intronic chr2:74089166(+) A-I      intronic chr2:74062563(+) A-I      intronic chr2:74089055(+) A-I      intronic chr2:74074164(+) A-I      intronic chr2:74085383(+) A-I      intronic chr2:74062579(+) A-I      intronic chr2:74080667(+) A-I      intronic chr2:74061118(+) A-I      intronic chr2:74080016(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STAMBP	chr2:74080804(+) A-I intron -    21960545 chr2:74081703(+) A-I intron -    21960545 chr2:74062229(+) A-G intron -    22484847 chr2:74070451(+) A-G intron -    22484847 chr2:74072858(+) A-G intron -    22484847 chr2:74072859(+) A-G intron -    22484847 chr2:74072876(+) A-G intron -    22484847 chr2:74072979(+) A-G intron -    22484847 chr2:74073497(+) A-G intron -    22484847 chr2:74073563(+) A-G intron -    22484847 chr2:74073741(+) A-G intron -    22484847 chr2:74074110(+) A-G intron -    22484847 chr2:74078879(+) A-G intron -    22484847 chr2:74079838(+) A-G intron -    22484847 chr2:74079871(+) A-G intron -    22484847 chr2:74079905(+) A-G intron -    22484847 chr2:74080663(+) A-G intron -    22484847 chr2:74080667(+) A-G intron -    22484847 chr2:74080702(+) A-G intron -    22484847 chr2:74080755(+) A-G intron -    22484847 chr2:74080804(+) A-G intron -    22484847 chr2:74081703(+) A-G intron -    22484847 chr2:74081881(+) A-G intron -    22484847 chr2:74082026(+) A-G intron -    22484847 chr2:74082036(+) A-G intron -    22484847 chr2:74082061(+) A-G intron -    22484847 chr2:74082071(+) A-G intron -    22484847 chr2:74088739(+) A-G intron -    22484847 chr2:74088746(+) A-G intron -    22484847 chr2:74088747(+) A-G intron -    22484847 chr2:74089036(+) A-G intron -    22484847 chr2:74089125(+) A-G intron -    22484847 chr2:74089166(+) A-G intron -    22484847 chr2:74089189(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STAMBP	chr2:74056096-74056097(+) m6A 5'UTR       25456834//24981863 chr2:74056175-74056176(+) m6A 5'UTR//intron       25456834//24981863 chr2:74074541-74074542(+) m6A CDS//exon       24981863//27773535//22608085 chr2:74074575-74074576(+) m6A CDS//exon       24981863//27773535//22608085 chr2:74074611-74074612(+) m6A CDS//exon       24981863//27773535//22608085 chr2:74074617-74074618(+) m6A CDS//exon       24981863//27773535//22608085 chr2:74074649-74074650(+) m6A CDS//exon       24981863//27773535//22608085 chr2:74074703-74074704(+) m6A CDS//exon//intron       24981863 chr2:74077522-74077523(+) Y CDS//exon       26075521 chr2:74077588-74077589(+) m6A CDS//exon       - chr2:74086395-74086396(+) m6A CDS//exon       - chr2:74089554-74089555(+) m6A 3'UTR//exon//intron       26404942 chr2:74089583-74089584(+) m6A 3'UTR//exon//intron       26404942 chr2:74089671-74089672(+) m6A 3'UTR//exon//intron       26404942 chr2:74091646-74091647(+) m6A 3'UTR//intron       - chr2:74091722-74091723(+) m6A 3'UTR//intron       - chr2:74091728-74091729(+) m6A 3'UTR//intron       - chr2:74091748-74091749(+) m6A 3'UTR//intron       - chr2:74093904-74093905(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	STAMBP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: STAMBP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.