Detail Information

Basic Information:


  VIRBase ID:  

HHID00053457

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           NR4A3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p NR4A3
miRBase
Accession/Entrez ID		 MIMAT0000458 8013
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CHN//CSMF//MINOR//NOR1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NR4A3
chr9:102606136(+) A-I      intronic
chr9:102606135(+) A-I      intronic
chr9:102606129(+) A-I      intronic
chr9:102624835(+) A-I      intronic
chr9:102624595(+) A-I      intronic
chr9:102624592(+) A-I      intronic
chr9:102624848(+) A-I      intronic
chr9:102624840(+) A-I      intronic
chr9:102606097(+) A-I      intronic
chr9:102606110(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NR4A3
chr9:102624275(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NR4A3
chr9:102584283-102584284(+) m6A 5'UTR       24284625//24981863//26404942
chr9:102587989-102587990(+) m6A 5'UTR       24284625
chr9:102588074-102588075(+) m6A 5'UTR       24284625
chr9:102590384-102590385(+) m6A CDS       24284625//24981863//26404942
chr9:102590418-102590419(+) m6A CDS       24284625//24981863//26404942
chr9:102590445-102590446(+) m6A CDS       24284625//24981863//26404942
chr9:102590533-102590534(+) m6A CDS       24284625//24981863//26404942
chr9:102591245-102591246(+) m6A CDS       26404942
chr9:102594973-102594974(+) m6A CDS       26404942
chr9:102595016-102595017(+) m6A CDS       26404942
chr9:102595028-102595029(+) m6A CDS       26404942
chr9:102595043-102595044(+) m6A CDS       26404942
chr9:102595612-102595613(+) m6A CDS       26404942
chr9:102595636-102595637(+) m6A CDS       26404942
chr9:102595704-102595705(+) m6A CDS       26404942
chr9:102607074-102607075(+) m6A CDS       26404942
chr9:102607118-102607119(+) m6A CDS       26404942
chr9:102609723-102609724(+) m6A CDS       26404942
chr9:102609757-102609758(+) m6A CDS       24284625//26404942
chr9:102609819-102609820(+) m6A CDS       24284625//24981863//26404942
chr9:102609846-102609847(+) m6A CDS       24284625//26404942
chr9:102625905-102625906(+) m6A CDS       24284625//26404942//22575960
chr9:102625920-102625921(+) m6A CDS       24284625//24981863//26404942//22608085
chr9:102625970-102625971(+) m6A CDS       24284625//24981863//26404942//22608085
chr9:102625986-102625987(+) m6A CDS       24284625//24981863//26404942//22608085
chr9:102626034-102626035(+) m6A CDS       24284625//24981863//26404942
chr9:102626090-102626091(+) m6A CDS       24284625//24981863//26404942
chr9:102626132-102626133(+) m6A CDS       24284625//24981863//26404942
chr9:102626224-102626225(+) m6A 3'UTR       24981863//26404942
chr9:102626280-102626281(+) m6A 3'UTR       24981863//26404942
chr9:102626327-102626328(+) m6A 3'UTR       24981863//26404942
chr9:102626442-102626443(+) m6A 3'UTR       26404942
chr9:102626490-102626491(+) m6A 3'UTR       26404942
chr9:102626533-102626534(+) m6A 3'UTR       26404942
chr9:102626539-102626540(+) m6A 3'UTR       26404942
chr9:102626632-102626633(+) m6A 3'UTR       26404942
chr9:102626643-102626644(+) m6A 3'UTR       26404942
chr9:102626713-102626714(+) m6A 3'UTR       26404942
chr9:102626723-102626724(+) m6A 3'UTR       26404942
chr9:102626749-102626750(+) m6A 3'UTR       26404942
chr9:102626922-102626923(+) m6A 3'UTR       26404942
chr9:102626945-102626946(+) m6A 3'UTR       26404942
chr9:102626998-102626999(+) m6A 3'UTR       26404942
chr9:102627056-102627057(+) m6A 3'UTR       26404942
chr9:102627138-102627139(+) m6A 3'UTR       26404942
chr9:102627156-102627157(+) m6A 3'UTR       26404942
chr9:102627183-102627184(+) m6A 3'UTR       26404942
chr9:102627234-102627235(+) m6A 3'UTR       26404942
chr9:102627443-102627444(+) m6A 3'UTR       26404942
chr9:102627494-102627495(+) m6A 3'UTR       26404942
chr9:102628129-102628130(+) m6A 3'UTR       26404942
chr9:102628159-102628160(+) m6A 3'UTR       26404942
chr9:102628218-102628219(+) m6A 3'UTR       26404942
chr9:102628258-102628259(+) m6A 3'UTR       26404942
chr9:102628279-102628280(+) m6A 3'UTR       26404942
chr9:102628285-102628286(+) m6A 3'UTR       26404942
chr9:102628350-102628351(+) m6A 3'UTR       26404942
chr9:102628428-102628429(+) m6A 3'UTR       26404942
chr9:102628486-102628487(+) m6A 3'UTR       26404942
chr9:102628601-102628602(+) m6A 3'UTR       26404942
chr9:102628606-102628607(+) m6A 3'UTR       26404942
chr9:102628617-102628618(+) m6A 3'UTR       26404942
chr9:102628678-102628679(+) m6A 3'UTR       26404942
chr9:102628908-102628909(+) m6A 3'UTR       26404942
chr9:102628966-102628967(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
NR4A3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: NR4A3

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 25086243 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//Akata cells//Raji cells//Sav I cells Interactor2 expression Downregulation
Description By targeting TP53INP1, miR-190 enhances cell survival by preventing apoptosis and relieving G0/G1 cell cycle arrest. Additionally, miR-190 down-regulates NR4A3, a cellular immediate-early gene for EBV reactivation, and inhibits the expression of the viral immediate-early gene bzlf1 and viral lytic DNA replication.

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