Basic Information:

  VIRBase ID:  

HHID00053454

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SOD2:  NM_001024465     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SOD2
miRBase Accession/Entrez ID	MIMAT0000458	6648
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GClnc1//IPO-B//IPOB//Mn-SOD//MNSOD//MVCD6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SOD2	chr6:160145846(-) A-I      intronic chr6:160145822(-) A-I      intronic chr6:160141999(-) A-I      intronic chr6:160141980(-) A-I      intronic chr6:160139212(-) A-I      intronic chr6:160108430(-) A-I      intronic chr6:160108408(-) A-I      intronic chr6:160104395(-) A-I      intronic chr6:160104393(-) A-I      intronic chr6:160104353(-) A-I      intronic chr6:160104417(-) A-I      intronic chr6:160143390(-) A-I      intronic chr6:160144863(-) A-I      intronic chr6:160144901(-) A-I      intronic chr6:160145064(-) A-I      intronic chr6:160145070(-) A-I      intronic chr6:160145261(-) A-I      intronic chr6:160145649(-) A-I      intronic chr6:160145760(-) A-I      intronic chr6:160145834(-) A-I      intronic chr6:160145772(-) A-I      intronic chr6:160107427(-) A-I      intronic chr6:160158126(-) A-I      intronic chr6:160106565(-) A-I      intronic chr6:160106555(-) A-I      intronic chr6:160106541(-) A-I      intronic chr6:160106538(-) A-I      intronic chr6:160106525(-) A-I      intronic chr6:160106524(-) A-I      intronic chr6:160131424(-) A-I      intronic chr6:160106511(-) A-I      intronic chr6:160106477(-) A-I      intronic chr6:160106467(-) A-I      intronic chr6:160106456(-) A-I      intronic chr6:160106450(-) A-I      intronic chr6:160106447(-) A-I      intronic chr6:160106444(-) A-I      intronic chr6:160106443(-) A-I      intronic chr6:160106439(-) A-I      intronic chr6:160106423(-) A-I      intronic chr6:160106360(-) A-I      intronic chr6:160158153(-) A-I      intronic chr6:160180273(-) A-I      intronic chr6:160142799(-) A-I      intronic chr6:160105517(-) A-I      intronic chr6:160106396(-) A-I      intronic chr6:160105519(-) A-I      intronic chr6:160106386(-) A-I      intronic chr6:160106380(-) A-I      intronic chr6:160140614(-) A-I      intronic chr6:160140656(-) A-I      intronic chr6:160140813(-) A-I      intronic chr6:160140823(-) A-I      intronic chr6:160141201(-) A-I      intronic chr6:160106487(-) A-I      intronic chr6:160106309(-) A-I      intronic chr6:160141286(-) A-I      intronic chr6:160141354(-) A-I      intronic chr6:160141355(-) A-I      intronic chr6:160142003(-) A-I      intronic chr6:160106351(-) A-I      intronic chr6:160142196(-) A-I      intronic chr6:160142197(-) A-I      intronic chr6:160142211(-) A-I      intronic chr6:160142469(-) A-I      intronic chr6:160142538(-) A-I      intronic chr6:160142651(-) A-I      intronic chr6:160142748(-) A-I      intronic chr6:160142771(-) A-I      intronic chr6:160142777(-) A-I      intronic chr6:160142802(-) A-I      intronic chr6:160142829(-) A-I      intronic chr6:160107428(-) A-I      intronic chr6:160107431(-) A-I      intronic chr6:160107435(-) A-I      intronic chr6:160107643(-) A-I      intronic chr6:160108337(-) A-I      intronic chr6:160108409(-) A-I      intronic chr6:160108431(-) A-I      intronic chr6:160108454(-) A-I      intronic chr6:160108511(-) A-I      intronic chr6:160108811(-) A-I      intronic chr6:160108819(-) A-I      intronic chr6:160108847(-) A-I      intronic chr6:160108935(-) A-I      intronic chr6:160109007(-) A-I      intronic chr6:160116592(-) A-I      intronic chr6:160117454(-) A-I      intronic chr6:160117467(-) A-I      intronic chr6:160117468(-) A-I      intronic chr6:160117540(-) A-I      intronic chr6:160117624(-) A-I      intronic chr6:160117902(-) A-I      intronic chr6:160123244(-) A-I      intronic chr6:160125074(-) A-I      intronic chr6:160125083(-) A-I      intronic chr6:160131381(-) A-I      intronic chr6:160131437(-) A-I      intronic chr6:160139089(-) A-I      intronic chr6:160139133(-) A-I      intronic chr6:160139192(-) A-I      intronic chr6:160139224(-) A-I      intronic chr6:160139253(-) A-I      intronic chr6:160139254(-) A-I      intronic chr6:160140372(-) A-I      intronic chr6:160140387(-) A-I      intronic chr6:160140389(-) A-I      intronic chr6:160140465(-) A-I      intronic chr6:160140546(-) A-I      intronic chr6:160140549(-) A-I      intronic chr6:160100867(-) A-I      3'UTR chr6:160100879(-) A-I      3'UTR chr6:160101858(-) A-I      3'UTR chr6:160100975(-) A-I      3'UTR chr6:160100969(-) A-I      3'UTR chr6:160100845(-) A-I      3'UTR chr6:160100857(-) A-I      3'UTR chr6:160100858(-) A-I      3'UTR chr6:160100970(-) A-I      3'UTR chr6:160100866(-) A-I      3'UTR chr6:160101709(-) A-I      3'UTR chr6:160100977(-) A-I      3'UTR chr6:160100898(-) A-I      3'UTR chr6:160100909(-) A-I      3'UTR chr6:160100923(-) A-I      3'UTR chr6:160100938(-) A-I      3'UTR chr6:160101911(-) A-I      3'UTR chr6:160101711(-) A-I      3'UTR chr6:160101725(-) A-I      3'UTR chr6:160101750(-) A-I      3'UTR chr6:160101776(-) A-I      3'UTR chr6:160101788(-) A-I      3'UTR chr6:160101796(-) A-I      3'UTR chr6:160101868(-) A-I      3'UTR chr6:160101964(-) A-I      3'UTR chr6:160101966(-) A-I      3'UTR chr6:160100836(-) A-I      3'UTR chr6:160100840(-) A-I      3'UTR chr6:160100841(-) A-I      3'UTR chr6:160100842(-) A-I      3'UTR chr6:160100876(-) A-I      3'UTR chr6:160100887(-) A-I      3'UTR chr6:160100890(-) A-I      3'UTR chr6:160100891(-) A-I      3'UTR chr6:160100896(-) A-I      3'UTR chr6:160100905(-) A-I      3'UTR chr6:160101751(-) A-I      3'UTR chr6:160101763(-) A-I      3'UTR chr6:160101785(-) A-I      3'UTR chr6:160101846(-) A-I      3'UTR chr6:160142026(-) A-I      intronic chr6:160108417(-) A-I      intronic chr6:160140388(-) A-I      intronic chr6:160117871(-) A-I      intronic chr6:160140853(-) A-I      intronic chr6:160145030(-) A-I      intronic chr6:160146347(-) A-I      intronic chr6:160143359(-) A-I      intronic chr6:160106449(-) A-I      intronic chr6:160106391(-) A-I      intronic chr6:160140893(-) A-I      intronic chr6:160144906(-) A-I      intronic chr6:160140751(-) A-I      intronic chr6:160106364(-) A-I      intronic chr6:160116696(-) A-I      intronic chr6:160116704(-) A-I      intronic chr6:160116755(-) A-I      intronic chr6:160140998(-) A-I      intronic chr6:160115915(-) A-I      intronic chr6:160180188(-) A-I      intronic chr6:160139193(-) A-I      intronic chr6:160117598(-) A-I      intronic chr6:160106506(-) A-I      intronic chr6:160141174(-) A-I      intronic chr6:160121640(-) A-I      intronic chr6:160140438(-) A-I      intronic chr6:160116765(-) A-I      intronic chr6:160106371(-) A-I      intronic chr6:160142650(-) A-I      intronic chr6:160106413(-) A-I      intronic chr6:160141191(-) A-I      intronic chr6:160117857(-) A-I      intronic chr6:160108886(-) A-I      intronic chr6:160139185(-) A-I      intronic chr6:160122503(-) A-I      intronic chr6:160145647(-) A-I      intronic chr6:160146266(-) A-I      intronic chr6:160145054(-) A-I      intronic chr6:160143147(-) A-I      intronic chr6:160117589(-) A-I      intronic chr6:160111150(-) A-I      intronic chr6:160139093(-) A-I      intronic chr6:160146389(-) A-I      intronic chr6:160116760(-) A-I      intronic chr6:160141309(-) A-I      intronic chr6:160141954(-) A-I      intronic chr6:160144873(-) A-I      intronic chr6:160106481(-) A-I      intronic chr6:160145851(-) A-I      intronic chr6:160141956(-) A-I      intronic chr6:160124104(-) A-I      intronic chr6:160140558(-) A-I      intronic chr6:160138436(-) A-I      intronic chr6:160139200(-) A-I      intronic chr6:160100944(-) A-I      3'UTR chr6:160101805(-) A-I      3'UTR chr6:160101802(-) A-I      3'UTR chr6:160100856(-) A-I      3'UTR chr6:160100940(-) A-I      3'UTR chr6:160101733(-) A-I      3'UTR chr6:160101724(-) A-I      3'UTR chr6:160100910(-) A-I      3'UTR chr6:160100932(-) A-I      3'UTR chr6:160100881(-) A-I      3'UTR chr6:160101714(-) A-I      3'UTR chr6:160100882(-) A-I      3'UTR chr6:160146456(-) A-I      intronic chr6:160117988(-) A-I      intronic chr6:160144856(-) A-I      intronic chr6:160146330(-) A-I      intronic chr6:160140652(-) A-I      intronic chr6:160180460(-) A-I      intronic chr6:160139132(-) A-I      intronic chr6:160138414(-) A-I      intronic chr6:160108395(-) A-I      intronic chr6:160145273(-) A-I      intronic chr6:160118035(-) A-I      intronic chr6:160140884(-) A-I      intronic chr6:160145274(-) A-I      intronic chr6:160107462(-) A-I      intronic chr6:160106372(-) A-I      intronic chr6:160108921(-) A-I      intronic chr6:160145013(-) A-I      intronic chr6:160123467(-) A-I      intronic chr6:160131418(-) A-I      intronic chr6:160145824(-) A-I      intronic chr6:160145740(-) A-I      intronic chr6:160145258(-) A-I      intronic chr6:160145223(-) A-I      intronic chr6:160140313(-) A-I      intronic chr6:160123480(-) A-I      intronic chr6:160140589(-) A-I      intronic chr6:160116659(-) A-I      intronic chr6:160144994(-) A-I      intronic chr6:160141341(-) A-I      intronic chr6:160145657(-) A-I      intronic chr6:160141974(-) A-I      intronic chr6:160140935(-) A-I      intronic chr6:160117817(-) A-I      intronic chr6:160123493(-) A-I      intronic chr6:160139122(-) A-I      intronic chr6:160105428(-) A-I      intronic chr6:160107580(-) A-I      intronic chr6:160146267(-) A-I      intronic chr6:160107422(-) A-I      intronic chr6:160117852(-) A-I      intronic chr6:160142468(-) A-I      intronic chr6:160144866(-) A-I      intronic chr6:160140785(-) A-I      intronic chr6:160140974(-) A-I      intronic chr6:160140617(-) A-I      intronic chr6:160108362(-) A-I      intronic chr6:160107596(-) A-I      intronic chr6:160108894(-) A-I      intronic chr6:160180633(-) A-I      intronic chr6:160124135(-) A-I      intronic chr6:160139114(-) A-I      intronic chr6:160108870(-) A-I      intronic chr6:160139199(-) A-I      intronic chr6:160107515(-) A-I      intronic chr6:160117844(-) A-I      intronic chr6:160180447(-) A-I      intronic chr6:160140460(-) A-I      intronic chr6:160106282(-) A-I      intronic chr6:160117555(-) A-I      intronic chr6:160108345(-) A-I      intronic chr6:160145784(-) A-I      intronic chr6:160139270(-) A-I      intronic chr6:160138442(-) A-I      intronic chr6:160140448(-) A-I      intronic chr6:160117815(-) A-I      intronic chr6:160144929(-) A-I      intronic chr6:160143410(-) A-I      intronic chr6:160139240(-) A-I      intronic chr6:160180459(-) A-I      intronic chr6:160138422(-) A-I      intronic chr6:160140601(-) A-I      intronic chr6:160125124(-) A-I      intronic chr6:160123589(-) A-I      intronic chr6:160145297(-) A-I      intronic chr6:160141308(-) A-I      intronic chr6:160144869(-) A-I      intronic chr6:160180294(-) A-I      intronic chr6:160123269(-) A-I      intronic chr6:160140477(-) A-I      intronic chr6:160110829(-) A-I      intronic chr6:160122546(-) A-I      intronic chr6:160146418(-) A-I      intronic chr6:160146401(-) A-I      intronic chr6:160124299(-) A-I      intronic chr6:160117953(-) A-I      intronic chr6:160107512(-) A-I      intronic chr6:160117814(-) A-I      intronic chr6:160117908(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SOD2	chr6:160100856(-) A-I intron -    15258596 chr6:160100882(-) A-I intron -    15258596 chr6:160100910(-) A-I intron -    15258596 chr6:160100882(-) A-G intron -    22484847 chr6:160101977(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SOD2	chr6:160090867-160090868(-) m6A 3'UTR       27773535 chr6:160090882-160090883(-) m6A 3'UTR       27773535 chr6:160090920-160090921(-) m6A 3'UTR       27773535 chr6:160100897-160100898(-) m6A 3'UTR//intron       26404942 chr6:160100974-160100975(-) m6A 3'UTR//intron       26404942 chr6:160101007-160101008(-) m6A 3'UTR//intron       26404942 chr6:160101024-160101025(-) m6A 3'UTR//intron       26404942 chr6:160102493-160102494(-) m6A 3'UTR//intron       26404942 chr6:160102526-160102527(-) m6A 3'UTR//intron       26404942 chr6:160102547-160102548(-) m6A 3'UTR//intron       26404942 chr6:160102593-160102594(-) m6A 3'UTR//intron       26404942 chr6:160105891-160105892(-) m6A 3'UTR//CDS//exon//intron       26404942 chr6:160105937-160105938(-) m6A 3'UTR//CDS//exon//intron       26404942 chr6:160109164-160109165(-) m6A 3'UTR//CDS//exon//intron       22575960 chr6:160109189-160109190(-) m6A 3'UTR//CDS//exon//intron       22575960 chr6:160112205-160112206(-) m6A 3'UTR//intron       27773535 chr6:160112229-160112230(-) m6A 3'UTR//intron       27773535 chr6:160112287-160112288(-) m6A 3'UTR//intron       27773535 chr6:160113112-160113113(-) m6A 3'UTR//intron       27773535 chr6:160113131-160113132(-) m6A 3'UTR//intron       27773535 chr6:160113139-160113140(-) m6A 3'UTR//intron       27773535 chr6:160113494-160113495(-) m6A 3'UTR//exon//intron       27773535 chr6:160113540-160113541(-) m6A CDS//exon//intron       27773535 chr6:160113598-160113599(-) m6A CDS//exon//intron       27773535 chr6:160113739-160113740(-) m6A CDS       24284625//27773535//27371828//27773536 chr6:160113801-160113802(-) m6A 5'UTR//CDS       24284625//27773535//27371828//27773536//22575960 chr6:160114237-160114238(-) Cm 5'UTR//intron       - chr6:160133901-160133902(-) m6A intron       27773535 chr6:160133916-160133917(-) m6A intron       27773535 chr6:160133936-160133937(-) m6A intron       27773535 chr6:160133957-160133958(-) m6A intron       27773535 chr6:160133989-160133990(-) m6A intron       27773535 chr6:160134515-160134516(-) m6A intron       27773535 chr6:160134591-160134592(-) m6A intron       27773535 chr6:160134790-160134791(-) m6A intron       - chr6:160134798-160134799(-) m6A intron       - chr6:160134806-160134807(-) m6A intron       - chr6:160134843-160134844(-) m6A intron       - chr6:160134867-160134868(-) m6A intron       - chr6:160141561-160141562(-) Y intron       16381836 chr6:160147954-160147955(-) m6A CDS//intron       24209618//24981863 chr6:160148316-160148317(-) m6A 5'UTR//CDS//intron       27773536 chr6:160151991-160151992(-) m6A 5'UTR//intron       - chr6:160169584-160169585(-) m6A 5'UTR       24209618//24981863//22608085 chr6:160169705-160169706(-) m6A 5'UTR       24981863//22608085 chr6:160181328-160181329(-) m6A exon//intron       24981863//22608085 chr6:160181943-160181944(-) m6A exon//intron       27773535 chr6:160182109-160182110(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182121-160182122(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182159-160182160(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182181-160182182(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182192-160182193(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182228-160182229(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182244-160182245(-) m6A 5'UTR//exon       25456834//27773535//22608085 chr6:160182355-160182356(-) m6A 5'UTR//exon       27773535//22608085 chr6:160182399-160182400(-) m6A 5'UTR//exon       27773535//22608085 chr6:160182661-160182662(-) m6A 5'UTR//exon       25456834 chr6:160182684-160182685(-) m6A 5'UTR//intron       25456834//22608085 chr6:160182701-160182702(-) m6A 5'UTR//intron       25456834//22608085 chr6:160182710-160182711(-) m6A 5'UTR//intron       25456834//22608085 chr6:160183031-160183032(-) m6A 5'UTR//exon       25456834//24981863 chr6:160183202-160183203(-) m6A 5'UTR//exon       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SOD2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Human colon carcinoma-derived cell line (HCT-116)     31298323 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SOD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.