Basic Information:

  VIRBase ID:  

HHID00053452

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PSMB2:  NM_001199779     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PSMB2
miRBase Accession/Entrez ID	MIMAT0000458	5690
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HC7-I

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSMB2	chr1:36067846(-) A-I      3'UTR chr1:36068146(-) A-I      3'UTR chr1:36065629(-) A-I      3'UTR chr1:36068212(-) A-I      3'UTR chr1:36068205(-) A-I      3'UTR chr1:36068207(-) A-I      3'UTR chr1:36065542(-) A-I      3'UTR chr1:36065740(-) A-I      3'UTR chr1:36067762(-) A-I      3'UTR chr1:36068274(-) A-I      3'UTR chr1:36066789(-) A-I      3'UTR chr1:36066816(-) A-I      3'UTR chr1:36066839(-) A-I      3'UTR chr1:36066866(-) A-I      3'UTR chr1:36068204(-) A-I      3'UTR chr1:36091276(-) A-I      intronic chr1:36091205(-) A-I      intronic chr1:36091138(-) A-I      intronic chr1:36091113(-) A-I      intronic chr1:36091107(-) A-I      intronic chr1:36087497(-) A-I      intronic chr1:36087396(-) A-I      intronic chr1:36087347(-) A-I      intronic chr1:36086358(-) A-I      intronic chr1:36086189(-) A-I      intronic chr1:36086171(-) A-I      intronic chr1:36077522(-) A-I      intronic chr1:36077424(-) A-I      intronic chr1:36075958(-) A-I      intronic chr1:36075852(-) A-I      intronic chr1:36091642(-) A-I      intronic chr1:36069453(-) A-I      intronic chr1:36073866(-) A-I      intronic chr1:36073880(-) A-I      intronic chr1:36075805(-) A-I      intronic chr1:36075822(-) A-I      intronic chr1:36075837(-) A-I      intronic chr1:36101391(-) A-I      intronic chr1:36101330(-) A-I      intronic chr1:36101262(-) A-I      intronic chr1:36100631(-) A-I      intronic chr1:36100465(-) A-I      intronic chr1:36100269(-) A-I      intronic chr1:36100247(-) A-I      intronic chr1:36100196(-) A-I      intronic chr1:36100155(-) A-I      intronic chr1:36097419(-) A-I      intronic chr1:36097405(-) A-I      intronic chr1:36097404(-) A-I      intronic chr1:36092816(-) A-I      intronic chr1:36092750(-) A-I      intronic chr1:36091576(-) A-I      intronic chr1:36091575(-) A-I      intronic chr1:36065512(-) A-I      3'UTR chr1:36068315(-) A-I      3'UTR chr1:36067794(-) A-I      3'UTR chr1:36067768(-) A-I      3'UTR chr1:36068268(-) A-I      3'UTR chr1:36065589(-) A-I      3'UTR chr1:36067764(-) A-I      3'UTR chr1:36066890(-) A-I      3'UTR chr1:36068331(-) A-I      3'UTR chr1:36068353(-) A-I      3'UTR chr1:36066720(-) A-I      3'UTR chr1:36066703(-) A-I      3'UTR chr1:36065517(-) A-I      3'UTR chr1:36068220(-) A-I      3'UTR chr1:36066873(-) A-I      3'UTR chr1:36068182(-) A-I      3'UTR chr1:36068267(-) A-I      3'UTR chr1:36068164(-) A-I      3'UTR chr1:36068156(-) A-I      3'UTR chr1:36066698(-) A-I      3'UTR chr1:36068151(-) A-I      3'UTR chr1:36068138(-) A-I      3'UTR chr1:36066860(-) A-I      3'UTR chr1:36068188(-) A-I      3'UTR chr1:36065718(-) A-I      3'UTR chr1:36068135(-) A-I      3'UTR chr1:36066804(-) A-I      3'UTR chr1:36066796(-) A-I      3'UTR chr1:36065711(-) A-I      3'UTR chr1:36068334(-) A-I      3'UTR chr1:36066773(-) A-I      3'UTR chr1:36067917(-) A-I      3'UTR chr1:36067801(-) A-I      3'UTR chr1:36067798(-) A-I      3'UTR chr1:36068270(-) A-I      3'UTR chr1:36066740(-) A-I      3'UTR chr1:36065706(-) A-I      3'UTR chr1:36066725(-) A-I      3'UTR chr1:36068300(-) A-I      3'UTR chr1:36068312(-) A-I      3'UTR chr1:36065618(-) A-I      3'UTR chr1:36100408(-) A-I      intronic chr1:36069614(-) A-I      intronic chr1:36101368(-) A-I      intronic chr1:36091634(-) A-I      intronic chr1:36065516(-) A-I      3'UTR chr1:36065692(-) A-I      3'UTR chr1:36068116(-) A-I      3'UTR chr1:36067886(-) A-I      3'UTR chr1:36075946(-) A-I      intronic chr1:36067887(-) A-I      3'UTR chr1:36068302(-) A-I      3'UTR chr1:36069602(-) A-I      intronic chr1:36067821(-) A-I      3'UTR chr1:36087473(-) A-I      intronic chr1:36100738(-) A-I      intronic chr1:36068276(-) A-I      3'UTR chr1:36066948(-) A-I      3'UTR chr1:36066730(-) A-I      3'UTR chr1:36068237(-) A-I      3'UTR chr1:36067912(-) A-I      3'UTR chr1:36068231(-) A-I      3'UTR chr1:36068166(-) A-I      3'UTR chr1:36066947(-) A-I      3'UTR chr1:36066832(-) A-I      3'UTR chr1:36100098(-) A-I      intronic chr1:36068325(-) A-I      3'UTR chr1:36091541(-) A-I      intronic chr1:36087457(-) A-I      intronic chr1:36068364(-) A-I      3'UTR chr1:36066800(-) A-I      3'UTR chr1:36068184(-) A-I      3'UTR chr1:36067689(-) A-I      3'UTR chr1:36068227(-) A-I      3'UTR chr1:36065504(-) A-I      3'UTR chr1:36065490(-) A-I      3'UTR chr1:36065654(-) A-I      3'UTR chr1:36065637(-) A-I      3'UTR chr1:36091706(-) A-I      intronic chr1:36092768(-) A-I      intronic chr1:36067022(-) A-I      3'UTR chr1:36065562(-) A-I      3'UTR chr1:36067811(-) A-I      3'UTR chr1:36066799(-) A-I      3'UTR chr1:36077422(-) A-I      intronic chr1:36067760(-) A-I      3'UTR chr1:36100252(-) A-I      intronic chr1:36068294(-) A-I      3'UTR chr1:36066875(-) A-I      3'UTR chr1:36067714(-) A-I      3'UTR chr1:36091196(-) A-I      intronic chr1:36091658(-) A-I      intronic chr1:36066805(-) A-I      3'UTR chr1:36067715(-) A-I      3'UTR chr1:36100275(-) A-I      intronic chr1:36068214(-) A-I      3'UTR chr1:36065697(-) A-I      3'UTR chr1:36066939(-) A-I      3'UTR chr1:36065708(-) A-I      3'UTR chr1:36068376(-) A-I      3'UTR chr1:36067788(-) A-I      3'UTR chr1:36067003(-) A-I      3'UTR chr1:36068275(-) A-I      3'UTR chr1:36067728(-) A-I      3'UTR chr1:36065529(-) A-I      3'UTR chr1:36067925(-) A-I      3'UTR chr1:36086460(-) A-I      intronic chr1:36065725(-) A-I      3'UTR chr1:36067907(-) A-I      3'UTR chr1:36065568(-) A-I      3'UTR chr1:36077523(-) A-I      intronic chr1:36065615(-) A-I      3'UTR chr1:36068369(-) A-I      3'UTR chr1:36065738(-) A-I      3'UTR chr1:36091173(-) A-I      intronic chr1:36101306(-) A-I      intronic chr1:36066806(-) A-I      3'UTR chr1:36068281(-) A-I      3'UTR chr1:36066847(-) A-I      3'UTR chr1:36067784(-) A-I      3'UTR chr1:36067833(-) A-I      3'UTR chr1:36065613(-) A-I      3'UTR chr1:36066854(-) A-I      3'UTR chr1:36068361(-) A-I      3'UTR chr1:36100751(-) A-I      intronic chr1:36100980(-) A-I      intronic chr1:36091728(-) A-I      intronic chr1:36065489(-) A-I      3'UTR chr1:36077325(-) A-I      intronic chr1:36065722(-) A-I      3'UTR chr1:36065530(-) A-I      3'UTR chr1:36100486(-) A-I      intronic chr1:36066909(-) A-I      3'UTR chr1:36068269(-) A-I      3'UTR chr1:36065642(-) A-I      3'UTR chr1:36065468(-) A-I      3'UTR chr1:36101247(-) A-I      intronic chr1:36067749(-) A-I      3'UTR chr1:36067809(-) A-I      3'UTR chr1:36067817(-) A-I      3'UTR chr1:36077084(-) A-I      intronic chr1:36068171(-) A-I      3'UTR chr1:36065593(-) A-I      3'UTR chr1:36100118(-) A-I      intronic chr1:36065486(-) A-I      3'UTR chr1:36067766(-) A-I      3'UTR chr1:36066779(-) A-I      3'UTR chr1:36067803(-) A-I      3'UTR chr1:36067876(-) A-I      3'UTR chr1:36066828(-) A-I      3'UTR chr1:36065588(-) A-I      3'UTR chr1:36068263(-) A-I      3'UTR chr1:36067740(-) A-I      3'UTR chr1:36091621(-) A-I      intronic chr1:36087434(-) A-I      intronic chr1:36066765(-) A-I      3'UTR chr1:36091712(-) A-I      intronic chr1:36086179(-) A-I      intronic chr1:36091349(-) A-I      intronic chr1:36068370(-) A-I      3'UTR chr1:36068266(-) A-I      3'UTR chr1:36100237(-) A-I      intronic chr1:36068210(-) A-I      3'UTR chr1:36067851(-) A-I      3'UTR chr1:36067838(-) A-I      3'UTR chr1:36100433(-) A-I      intronic chr1:36067870(-) A-I      3'UTR chr1:36065700(-) A-I      3'UTR chr1:36076208(-) A-I      intronic chr1:36068277(-) A-I      3'UTR chr1:36091711(-) A-I      intronic chr1:36067850(-) A-I      3'UTR chr1:36100187(-) A-I      intronic chr1:36101281(-) A-I      intronic chr1:36065491(-) A-I      3'UTR chr1:36068293(-) A-I      3'UTR chr1:36065625(-) A-I      3'UTR chr1:36100529(-) A-I      intronic chr1:36065628(-) A-I      3'UTR chr1:36100206(-) A-I      intronic chr1:36077082(-) A-I      intronic chr1:36066783(-) A-I      3'UTR chr1:36067727(-) A-I      3'UTR chr1:36068175(-) A-I      3'UTR chr1:36069524(-) A-I      intronic chr1:36104743(-) A-I      intronic chr1:36065477(-) A-I      3'UTR chr1:36068278(-) A-I      3'UTR chr1:36097567(-) A-I      intronic chr1:36068196(-) A-I      3'UTR chr1:36067752(-) A-I      3'UTR chr1:36068243(-) A-I      3'UTR chr1:36067677(-) A-I      3'UTR chr1:36068247(-) A-I      3'UTR chr1:36100644(-) A-I      intronic chr1:36065655(-) A-I      3'UTR chr1:36068295(-) A-I      3'UTR chr1:36068195(-) A-I      3'UTR chr1:36075941(-) A-I      intronic chr1:36067711(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSMB2	chr1:36065477(-) A-I exon 3'UTR    15258596 chr1:36065489(-) A-I exon 3'UTR    15258596 chr1:36065490(-) A-I exon 3'UTR    15258596 chr1:36065516(-) A-I exon 3'UTR    15258596 chr1:36065529(-) A-I exon 3'UTR    15258596 chr1:36065562(-) A-I exon 3'UTR    15258596 chr1:36065588(-) A-I exon 3'UTR    15258596 chr1:36065615(-) A-I exon 3'UTR    15258596   //21960545 chr1:36065700(-) A-I exon 3'UTR    15258596 chr1:36065708(-) A-I exon 3'UTR    15258596 chr1:36065722(-) A-I exon 3'UTR    15258596 chr1:36065725(-) A-I exon 3'UTR    15258596 chr1:36067760(-) A-I exon 3'UTR    15258596   //21960545 chr1:36067817(-) A-I exon 3'UTR    15342557   //15258596   //21960545   //22327324 chr1:36067833(-) A-I exon 3'UTR    15258596   //21960545 chr1:36067838(-) A-I exon 3'UTR    15342557   //15258596   //21960545 chr1:36067886(-) A-I exon 3'UTR    15258596   //21960545 chr1:36068184(-) A-I exon 3'UTR    15342557   //15258596 chr1:36068210(-) A-I exon 3'UTR    15342557   //15258596   //21960545   //22327324 chr1:36068214(-) A-I exon 3'UTR    15258596 chr1:36068275(-) A-I exon 3'UTR    15258596 chr1:36068276(-) A-I exon 3'UTR    15258596 chr1:36068278(-) A-I exon 3'UTR    15258596 chr1:36068281(-) A-I exon 3'UTR    15342557   //15258596 chr1:36068295(-) A-I exon 3'UTR    15342557   //15258596   //22327324 chr1:36068325(-) A-I exon 3'UTR    15258596 chr1:36068369(-) A-I exon 3'UTR    15258596   //21960545   //22327324 chr1:36068370(-) A-I exon 3'UTR    15258596   //21960545   //22327324 chr1:36068376(-) A-I exon 3'UTR    15342557   //15258596 chr1:36068231(-) A-I exon 3'UTR    21960545   //22327324 chr1:36067784(-) A-I exon 3'UTR    21960545 chr1:36067925(-) A-I exon 3'UTR    21960545 chr1:36065613(-) A-I exon 3'UTR    21960545 chr1:36067752(-) A-I exon 3'UTR    21960545 chr1:36065477(-) A-G exon 3'UTR    22484847 chr1:36065486(-) A-G exon 3'UTR    22484847 chr1:36065489(-) A-G exon 3'UTR    22484847 chr1:36065490(-) A-G exon 3'UTR    22484847 chr1:36065504(-) A-G exon 3'UTR    22484847 chr1:36065516(-) A-G exon 3'UTR    22484847 chr1:36065529(-) A-G exon 3'UTR    22484847 chr1:36065562(-) A-G exon 3'UTR    22484847 chr1:36065593(-) A-G exon 3'UTR    22484847 chr1:36065613(-) A-G exon 3'UTR    22484847 chr1:36065615(-) A-G exon 3'UTR    22484847 chr1:36065637(-) A-G exon 3'UTR    22484847 chr1:36065642(-) A-G exon 3'UTR    22484847 chr1:36065654(-) A-G exon 3'UTR    22484847 chr1:36065655(-) A-G exon 3'UTR    22484847 chr1:36065708(-) A-G exon 3'UTR    22484847 chr1:36065725(-) A-G exon 3'UTR    22484847 chr1:36065738(-) A-G exon 3'UTR    22484847 chr1:36066765(-) A-G exon 3'UTR    22484847 chr1:36066783(-) A-G exon 3'UTR    22484847 chr1:36066799(-) A-G exon 3'UTR    22484847 chr1:36066805(-) A-G exon 3'UTR    22484847 chr1:36066806(-) A-G exon 3'UTR    22484847 chr1:36066828(-) A-G exon 3'UTR    22484847 chr1:36066832(-) A-G exon 3'UTR    22484847 chr1:36067677(-) A-G exon 3'UTR    22484847 chr1:36067711(-) A-G exon 3'UTR    22484847 chr1:36067714(-) A-G exon 3'UTR    22484847 chr1:36067716(-) C-T exon 3'UTR    22484847 chr1:36067728(-) A-G exon 3'UTR    22484847 chr1:36067749(-) A-G exon 3'UTR    22484847 chr1:36067752(-) A-G exon 3'UTR    22484847 chr1:36067766(-) A-G exon 3'UTR    22484847 chr1:36067784(-) A-G exon 3'UTR    22484847 chr1:36067817(-) A-G exon 3'UTR    22484847 chr1:36067821(-) A-G exon 3'UTR    22484847 chr1:36067838(-) A-G exon 3'UTR    22484847 chr1:36067886(-) A-G exon 3'UTR    22484847 chr1:36067925(-) A-G exon 3'UTR    22484847 chr1:36068116(-) A-G exon 3'UTR    22484847 chr1:36068166(-) A-G exon 3'UTR    22484847 chr1:36068175(-) A-G exon 3'UTR    22484847 chr1:36068184(-) A-G exon 3'UTR    22484847 chr1:36068195(-) A-G exon 3'UTR    22484847 chr1:36068196(-) A-G exon 3'UTR    22484847 chr1:36068210(-) A-G exon 3'UTR    22484847 chr1:36068227(-) A-G exon 3'UTR    22484847 chr1:36068231(-) A-G exon 3'UTR    22484847 chr1:36068237(-) A-G exon 3'UTR    22484847 chr1:36068243(-) A-G exon 3'UTR    22484847 chr1:36068275(-) A-G exon 3'UTR    22484847 chr1:36068276(-) A-G exon 3'UTR    22484847 chr1:36068277(-) A-G exon 3'UTR    22484847 chr1:36068278(-) A-G exon 3'UTR    22484847 chr1:36068281(-) A-G exon 3'UTR    22484847 chr1:36068294(-) A-G exon 3'UTR    22484847 chr1:36068295(-) A-G exon 3'UTR    22484847 chr1:36068325(-) A-G exon 3'UTR    22484847 chr1:36068364(-) A-G exon 3'UTR    22484847 chr1:36068369(-) A-G exon 3'UTR    22484847 chr1:36068370(-) A-G exon 3'UTR    22484847 chr1:36073795(-) T-C intron -    22484847 chr1:36075946(-) A-G intron -    22484847 chr1:36076208(-) A-G intron -    22484847 chr1:36077082(-) A-G intron -    22484847 chr1:36077084(-) A-G intron -    22484847 chr1:36077325(-) A-G intron -    22484847 chr1:36077523(-) A-G intron -    22484847 chr1:36086179(-) A-G intron -    22484847 chr1:36087434(-) A-G intron -    22484847 chr1:36091173(-) A-G intron -    22484847 chr1:36091196(-) A-G intron -    22484847 chr1:36091349(-) A-G intron -    22484847 chr1:36091621(-) A-G intron -    22484847 chr1:36091658(-) A-G intron -    22484847 chr1:36091712(-) A-G intron -    22484847 chr1:36091728(-) A-G intron -    22484847 chr1:36099979(-) A-C intron -    22484847 chr1:36099983(-) C-G intron -    22484847 chr1:36100118(-) A-G intron -    22484847 chr1:36100187(-) A-G intron -    22484847 chr1:36100206(-) A-G intron -    22484847 chr1:36100237(-) A-G intron -    22484847 chr1:36100433(-) A-G intron -    22484847 chr1:36100529(-) A-G intron -    22484847 chr1:36100738(-) A-G intron -    22484847 chr1:36100751(-) A-G intron -    22484847 chr1:36101281(-) A-G intron -    22484847 chr1:36101306(-) A-G intron -    22484847 chr1:36101368(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSMB2	chr1:36068933-36068934(-) Y CDS       25219674//26075521 chr1:36070846-36070847(-) Am CDS//exon       - chr1:36074938-36074939(-) m6A CDS//exon       22575960 chr1:36074992-36074993(-) m6A 5'UTR//CDS//exon       22575960 chr1:36107059-36107060(-) m6A 5'UTR       24981863//22575960 chr1:36107092-36107093(-) m6A 5'UTR       24284625//24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PSMB2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PSMB2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.