Basic Information:

  VIRBase ID:  

HHID00053448

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          KPNA5:  NM_002269     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	KPNA5
miRBase Accession/Entrez ID	MIMAT0000458	3841
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IPOA6//SRP6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KPNA5	chr6:117025240(+) A-I      intronic chr6:117025931(+) A-I      intronic chr6:117016243(+) A-I      intronic chr6:117016172(+) A-I      intronic chr6:117012529(+) A-I      intronic chr6:117005278(+) A-I      intronic chr6:117003472(+) A-I      intronic chr6:117033365(+) A-I      intronic chr6:117033381(+) A-I      intronic chr6:117003478(+) A-I      intronic chr6:117030381(+) A-I      intronic chr6:117028196(+) A-I      intronic chr6:117028184(+) A-I      intronic chr6:117028180(+) A-I      intronic chr6:117028172(+) A-I      intronic chr6:117030380(+) A-I      intronic chr6:117033351(+) A-I      intronic chr6:117016259(+) A-I      intronic chr6:117025863(+) A-I      intronic chr6:117037062(+) A-I      intronic chr6:117025796(+) A-I      intronic chr6:117016289(+) A-I      intronic chr6:117005344(+) A-I      intronic chr6:117030989(+) A-I      intronic chr6:117033234(+) A-I      intronic chr6:117003286(+) A-I      intronic chr6:117040103(+) A-I      intronic chr6:117030386(+) A-I      intronic chr6:117016247(+) A-I      intronic chr6:117025867(+) A-I      intronic chr6:117005350(+) A-I      intronic chr6:117016295(+) A-I      intronic chr6:117025895(+) A-I      intronic chr6:117042525(+) A-I      intronic chr6:117025312(+) A-I      intronic chr6:117003412(+) A-I      intronic chr6:117011794(+) A-I      intronic chr6:117027773(+) A-I      intronic chr6:117025987(+) A-I      intronic chr6:117030981(+) A-I      intronic chr6:117011655(+) A-I      intronic chr6:117030460(+) A-I      intronic chr6:117023590(+) A-I      intronic chr6:117011562(+) A-I      intronic chr6:117004900(+) A-I      intronic chr6:117024591(+) A-I      intronic chr6:117011366(+) A-I      intronic chr6:117023699(+) A-I      intronic chr6:117030049(+) A-I      intronic chr6:117030510(+) A-I      intronic chr6:117037019(+) A-I      intronic chr6:117012298(+) A-I      intronic chr6:117011563(+) A-I      intronic chr6:117024635(+) A-I      intronic chr6:117025968(+) A-I      intronic chr6:117016308(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KPNA5	chr6:117005056(+) G-T intron -    22484847 chr6:117021478(+) T-A intron -    22484847 chr6:117021646(+) A-C intron -    22484847 chr6:117023618(+) A-G intron -    22484847 chr6:117025937(+) A-G intron -    22484847 chr6:117030981(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KPNA5	chr6:117002387-117002388(+) m6A 5'UTR       24981863 chr6:117002462-117002463(+) m6A 5'UTR       24981863 chr6:117002618-117002619(+) m6A 5'UTR//intron       24981863 chr6:117010597-117010598(+) m6A CDS       24981863 chr6:117033549-117033550(+) Y intron       16381836 chr6:117033550-117033551(+) Y intron       16381836 chr6:117033554-117033555(+) Gm intron       16381836 chr6:117033555-117033556(+) Gm intron       16381836 chr6:117033558-117033559(+) Y intron       16381836 chr6:117050752-117050753(+) m6A CDS       22608085 chr6:117050781-117050782(+) m6A CDS       22608085 chr6:117050812-117050813(+) m6A CDS       24284625//22608085 chr6:117050839-117050840(+) m6A CDS       24284625//24981863//22608085 chr6:117053371-117053372(+) m6A CDS       24284625//24981863//22608085 chr6:117053427-117053428(+) m6A CDS       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	KPNA5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: KPNA5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.