Detail Information

Basic Information:


  VIRBase ID:  

HHID00053443

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           CCND2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p CCND2
miRBase
Accession/Entrez ID		 MIMAT0000458 894
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - KIAK0002//MPPH3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCND2
chr12:4407683(+) A-I      intronic
chr12:4406504(+) A-I      intronic
chr12:4408273(+) A-I      intronic
chr12:4408319(+) A-I      intronic
chr12:4407661(+) A-I      intronic
chr12:4408272(+) A-I      intronic
chr12:4406535(+) A-I      intronic
chr12:4408325(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCND2
chr12:4406341(+) A-T intron -    22484847
chr12:4406592(+) C-T intron -    22484847
chr12:4406734(+) C-T intron -    22484847
chr12:4406735(+) T-C intron -    22484847
chr12:4406736(+) C-A intron -    22484847
chr12:4407661(+) A-G intron -    22484847
chr12:4404682(+) T-C intron -    22484847
chr12:4408272(+) A-G intron -    22484847
chr12:4408273(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCND2
chr12:4382959-4382960(+) m6A 5'UTR       25456834//24981863
chr12:4382977-4382978(+) m6A 5'UTR       25456834//24981863
chr12:4383080-4383081(+) m6A 5'UTR       25456834//24981863
chr12:4383140-4383141(+) m6A 5'UTR       24981863
chr12:4383146-4383147(+) m6A 5'UTR       -
chr12:4383154-4383155(+) m6A 5'UTR       -
chr12:4409504-4409505(+) m6A 3'UTR       22608085
chr12:4409518-4409519(+) m6A 3'UTR       24981863//22608085
chr12:4409578-4409579(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409622-4409623(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409650-4409651(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409673-4409674(+) m6A 3'UTR       24209618//24981863//22608085
chr12:4409694-4409695(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
CCND2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: CCND2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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